Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study

dc.contributor.author Karci, Bilge
dc.contributor.author Savaş, Hasan Basri
dc.contributor.author Savas, Hasan Basri
dc.contributor.other Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
dc.contributor.other 10. Faculty of Medicine / Tıp Fakültesi
dc.contributor.other 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
dc.date.accessioned 2024-05-09T10:22:41Z
dc.date.available 2024-05-09T10:22:41Z
dc.date.issued 2024
dc.description.abstract Background This study aimed to assess and compare the concentrations of growth factors, white blood cells (WBCs), and platelets in injectable platelet-rich fibrin (i-PRF) derived from people with healthy periodontal conditions and those with chronic periodontitis.Methods Venous blood samples were obtained from 30 patients diagnosed with chronic periodontitis (test group) and 30 participants with healthy periodontal conditions (control group). The i-PRF was then acquired from centrifuged blood. The growth factors (VEGF, IGF-1, TGF-beta 1, PDGF-BB and EGF) released from the i-PRF samples were compared between groups with ELISA testing. The amounts of WBCs and platelets were also compared.Results No significant differences in the concentrations of growth factors were found between the groups (the mean values for the control and test groups were, respectively: IGF: 38.82, 42.46; PDGF: 414.25, 466.28; VEGF: 375.69, 412.18; TGF-beta 1: 21.50, 26.21; EGF: 138.62, 154.82). The test group exhibited a significantly higher WBC count than the control group (8.80 vs. 6.60, respectively). However, the platelet count did not show a statistically significant difference between the groups (control group 242.0 vs. test group 262.50). No significant correlation was observed between WBC count and growth factor level in either group.Conclusions The growth factor levels in i-PRFs did not exhibit significant difference between the two groups. This suggests that the levels of these growth factors may be unaffected by the periodontal disease. en_US
dc.description.sponsorship ALKU BAP en_US
dc.description.sponsorship Not applicable. en_US
dc.identifier.citation Karcı, B., & Savas, H. B. (2024). Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study. BMC oral health, 24(1), 527. https://doi.org/10.1186/s12903-024-04301-x en_US
dc.identifier.doi 10.1186/s12903-024-04301-x
dc.identifier.issn 1472-6831
dc.identifier.scopus 2-s2.0-85192003237
dc.identifier.uri https://doi.org/10.1186/s12903-024-04301-x
dc.language.iso en en_US
dc.publisher Bmc en_US
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject Injectable Platelet Rich Fibrin en_US
dc.subject Growth Factors en_US
dc.subject White Blood Cells en_US
dc.subject Platelets en_US
dc.subject Chronic Periodontitis en_US
dc.title Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study
dc.title Comparison of Growth Factor Levels in Injectable Platelet-Rich Fibrin Obtained From Healthy Individuals and Patients With Chronic Periodontitis: a Pilot Study en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.institutional Savaş, Hasan Basri
gdc.author.scopusid 57226899144
gdc.author.scopusid 56562721800
gdc.author.wosid Savas, Hasan Basri/Jts-6948-2023
gdc.author.wosid Karcı, Bilge/Abb-3373-2020
gdc.description.department Artuklu University en_US
gdc.description.departmenttemp [Karci, Bilge] Alanya Alaaddin Keykubat Univ, Fac Dent, Dept Periodontol, Antalya, Turkiye; [Savas, Hasan Basri] Mardin Artuklu Univ, Fac Med, Dept Biochem, Mardin, Turkiye en_US
gdc.description.issue 1 en_US
gdc.description.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
gdc.description.scopusquality Q2
gdc.description.volume 24 en_US
gdc.description.woscitationindex Science Citation Index Expanded
gdc.description.wosquality Q2
gdc.identifier.pmid 38702671
gdc.identifier.wos WOS:001225960700003
gdc.scopus.citedcount 3
gdc.wos.citedcount 3
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