Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study
dc.contributor.author | Karci, Bilge | |
dc.contributor.author | Savaş, Hasan Basri | |
dc.contributor.author | Savas, Hasan Basri | |
dc.contributor.other | Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü | |
dc.contributor.other | 10. Faculty of Medicine / Tıp Fakültesi | |
dc.contributor.other | 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi | |
dc.date.accessioned | 2024-05-09T10:22:41Z | |
dc.date.available | 2024-05-09T10:22:41Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Background This study aimed to assess and compare the concentrations of growth factors, white blood cells (WBCs), and platelets in injectable platelet-rich fibrin (i-PRF) derived from people with healthy periodontal conditions and those with chronic periodontitis.Methods Venous blood samples were obtained from 30 patients diagnosed with chronic periodontitis (test group) and 30 participants with healthy periodontal conditions (control group). The i-PRF was then acquired from centrifuged blood. The growth factors (VEGF, IGF-1, TGF-beta 1, PDGF-BB and EGF) released from the i-PRF samples were compared between groups with ELISA testing. The amounts of WBCs and platelets were also compared.Results No significant differences in the concentrations of growth factors were found between the groups (the mean values for the control and test groups were, respectively: IGF: 38.82, 42.46; PDGF: 414.25, 466.28; VEGF: 375.69, 412.18; TGF-beta 1: 21.50, 26.21; EGF: 138.62, 154.82). The test group exhibited a significantly higher WBC count than the control group (8.80 vs. 6.60, respectively). However, the platelet count did not show a statistically significant difference between the groups (control group 242.0 vs. test group 262.50). No significant correlation was observed between WBC count and growth factor level in either group.Conclusions The growth factor levels in i-PRFs did not exhibit significant difference between the two groups. This suggests that the levels of these growth factors may be unaffected by the periodontal disease. | en_US |
dc.description.sponsorship | ALKU BAP | en_US |
dc.description.sponsorship | Not applicable. | en_US |
dc.identifier.citation | Karcı, B., & Savas, H. B. (2024). Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study. BMC oral health, 24(1), 527. https://doi.org/10.1186/s12903-024-04301-x | en_US |
dc.identifier.doi | 10.1186/s12903-024-04301-x | |
dc.identifier.issn | 1472-6831 | |
dc.identifier.scopus | 2-s2.0-85192003237 | |
dc.identifier.uri | https://doi.org/10.1186/s12903-024-04301-x | |
dc.language.iso | en | en_US |
dc.publisher | Bmc | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Injectable Platelet Rich Fibrin | en_US |
dc.subject | Growth Factors | en_US |
dc.subject | White Blood Cells | en_US |
dc.subject | Platelets | en_US |
dc.subject | Chronic Periodontitis | en_US |
dc.title | Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study | |
dc.title | Comparison of Growth Factor Levels in Injectable Platelet-Rich Fibrin Obtained From Healthy Individuals and Patients With Chronic Periodontitis: a Pilot Study | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
gdc.author.institutional | Savaş, Hasan Basri | |
gdc.author.scopusid | 57226899144 | |
gdc.author.scopusid | 56562721800 | |
gdc.author.wosid | Savas, Hasan Basri/Jts-6948-2023 | |
gdc.author.wosid | Karcı, Bilge/Abb-3373-2020 | |
gdc.description.department | Artuklu University | en_US |
gdc.description.departmenttemp | [Karci, Bilge] Alanya Alaaddin Keykubat Univ, Fac Dent, Dept Periodontol, Antalya, Turkiye; [Savas, Hasan Basri] Mardin Artuklu Univ, Fac Med, Dept Biochem, Mardin, Turkiye | en_US |
gdc.description.issue | 1 | en_US |
gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
gdc.description.scopusquality | Q2 | |
gdc.description.volume | 24 | en_US |
gdc.description.woscitationindex | Science Citation Index Expanded | |
gdc.description.wosquality | Q2 | |
gdc.identifier.pmid | 38702671 | |
gdc.identifier.wos | WOS:001225960700003 | |
gdc.scopus.citedcount | 3 | |
gdc.wos.citedcount | 3 | |
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