Sağlık Hizmetleri Meslek Yüksekokulu

Permanent URI for this communityhttps://hdl.handle.net/20.500.12514/32

Browse

Now showing 1 - 20 of 180

Citation - WoS: 7
Citation - Scopus: 16
Adsorptive Performance of Magnetic Nano-Biosorbent for Binary Dyes and Investigation of Comparative Biosorption
(Springer Nature, 2019) Tarhan, T.; Tarhan, Tuba; Tural, B.; Boga, K.; Tural, S.; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The individual and competitive biosorption capacities of Metanil Yellow (MY) and Reactive Black 5 (RB5) by glutaraldehyde cross-linked magnetic chitosan nanoparticles (GMCNs) were studied. Competitive biosorption of the MY and RB5 dyes by the GMCNs has never been reported previously. Fourier transform infrared technique has been used to show the biosorbed MY and RB5 dyes onto GMCNs. During the studies, various essential factors influencing the biosorption, like adsorbate concentration, pH of the solution and contact time have been monitored. The equilibrium was achieved within 17 h for single dyes and 3 h for binary mixture at pH 3. The biosorption capacities were 620 mg/g for dye MY and 2549 mg/g for dye RB5 at pH 3, 30 °C. The second-order kinetic model has good compatibility with the dynamical biosorption behavior of a single dye and binary mixture. In order to study the competition biosorption of the RB5 and MY dyes in mixture solutions, the intraparticle diffusion model was used. Competition biosorption through analysis of the intraparticle diffusion model apparently favored the RB5 dye more than the MY dye on the GMCNs in mixture solutions. The biosorbent was regenerated efficiently through the alkaline solution and was then reused ten times for biosorption–desorption cycles. © 2018, Springer Nature Switzerland AG.
Altın nanomalzeme sentezi ve karekterizasyonu
(2019) Baran, Mehmet Fırat; Saydut, Abdurrahman; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Nanobiyoteknoloji, nanobilim ve teknolojide çarpıcı ve en hızlı gelişen alanlardan biridir. Altın nanopartikülleri (AuNP'ler), yeşil sentez ile herhangi bir yüzey aktif madde, stabilizatör ve kimyasal madde kullanılmadanbıttım(Pistacia terebinthus) yaprak özütü kullanılarak elde edilmiştir. Elde edilen AuNP’lerin karekterizasyonu UV-vis, SEM-EDX, XRD, FTIR ve TGA-DTA ile yapıldı. SEM-EDX, analizi incelendiğinde sentezlenen nanomalzemelerin kristal boyutunun 100 nm’nin altında olduğu ve kristal yapısının küresel olduğu anlaşılmaktadır. UV-vis, analizi verileri gösterdiki oda koşullarında farklı zaman aralıklarında yapılan ölçümler sonucunda renk değişimi ile maksimum dalga boyunun 335 nm’de karesteristik pik verdiği görüldü. XRD analizi verilerinden kristal yapılarının boyutu 14.37 nm büyüklükte olduğu hesaplandı. Ayrıca çalışmamızda sentezlenen nanomalzemenin TGA-DTA analizi yapılarak nanoparçacıkların 1000 oC ‘ye kadar dayanıklı olduğu rapor edildi
Citation - WoS: 11
Citation - Scopus: 11
Anoxybacillus sp. SO B1-Immobilized Amberlite XAD-16 for Solid-Phase Preconcentration of Cu(II) and Pb(II) and Their Determinations by Flame Atomic Absorption Spectrometry
(TAYLOR & FRANCIS INC, 2015) Dündar, Abdurrahman; Ozdemir, Sadin; Dolak, Ibrahim; Okumus, Veysi; Dundar, Abdurrahman; Ziyadanogullari, Berrin; Aksoy, Zehra; Onat, Ruken; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
A new method for the determination of Cu(II) and Pb(II) by flame atomic absorption spectrometry (FAAS) after preconcentrating on a column containing Anoxybacillus sp. SO B1-immobilized Amberlite XAD-16 was developed. The functional groups of Anoxybacillus sp. SO B1 immobilized on Amberlite XAD-16 were characterized in KBr tablets by Fourier transform infrared (FT-IR) spectrometry. Various parameters such as pH, amount of the adsorbent, eluent type and volume, and flow rate of the sample solution were studied. The optimum pH values of quantitative sorption for Cu(II) and Pb(II) were found to be pH 7.0 and 5.0 and Cu(II) and Pb(II) ions could be quantitatively eluted with 5.0ml of 1.0mol L-1 HCI and 10.0ml of 0.25mol L-1 HNO3, respectively. Recoveries of Cu(II) and Pb(II) were found to be 100.9 +/- 1.57% and 100.3 +/- 0.49% (N = 5), the limits of detection of Cu(II) and Pb(II) in the determination by FAAS (3s, N = 10) were found to be 0.8 and 1.6 mu g L-1, respectively. The proposed enrichment method was applied for metal ion determination from water samples such as two parts of Tigris River water in Diyarbakir and Elazig, Lake of Hazar in Elazig, and tap water in Diyarbakir. Furthermore, the accuracy of the proposed method was verified by studying the analytical recovery and by analyzing certified reference material (NCS-DC 73350 leaves of poplar).
ANTİ-KANSER İLAÇ YÜKLENMİŞ MANYETİK O-KARBOKSİ METİL KİTOSAN NANOKOMPOZİTİN SİTOTOKSİSİTE ÇALIŞMALRI
(2019) Tarhan, Tuba; Tural, Bilsen; Tural, Servet; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Günümüzde kanser kemoterapisinin en önemli sorunlarına çözüm bulmak için nanoboyutta ilaç taşıyıcı sistemler geliştirilmiştir. Nanoboyuttaki kontrollü ilaç taşıma sistemleri tümör hedeflenmesine olanak sağlamıştır. Nanotaşıyıcılar arasından, biyouyumlu polimer kaplı süperparamanyetik nanoparçacıklar dışardan uygulanan manyetik alan ile istenilen bölgeye hedeflenebilme özelliklerine sahiptirler. Bu sayede ilaç hedeflenen bölgeye güvenli bir şekilde taşınabilmektedir. Bu çalışmada daha önce sentez ve karakterizasyonu yapılmış Manyetik O-Karboksimetil Kitosan nanokompozitine anti kanser ilaç olan Topotekan yükleme çalışmaları yapılmış olup, burada topotekan yüklü manyetik O-Karboksimetil Kitosan nanokompozitinin prostat kanseri Du145 ve sağlıklı insan prostat PNT1A hücre hattı üzerine sitotoksisite çalışmaları yapılmış ve sonuçları değerlendirilmiştir. Anahtar Kelimeler: Polimer Kaplı Süperparamanyetik Nanokompozit, Topotekan, Sitotoksisite, DU145 ve PNT1A
Citation - WoS: 20
Citation - Scopus: 26
Antibiotic Removal from the Aquatic Environment with Activated Carbon Produced from Pumpkin Seeds
(Molecules, 2022) Alacabey, İhsan; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Antibiotics are among the most critical environmental pollutant drug groups. Adsorption is one of the methods used to eliminate these pollutants. In this study, activated carbon was produced from pumpkin seed shells and subsequently modified with KOH. The adsorbent obtained through this procedure was used to remove ciprofloxacin from aqueous systems. Fourier Transform-Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), elemental, X-ray Photoelectron Spectroscopy (XPS), Brunauer–Emmett–Teller (BET) and Zeta analyses were used to characterize the adsorbent. The surface area, in particular, was found to be a very remarkable value of 2730 m2/g. The conditions of the adsorption experiments were optimized based on interaction time, adsorbent amount, pH and temperature. Over 99% success was achieved in removal operations carried out under the most optimal conditions, with an absorption capacity of 884.9 mg·g−1. In addition, the Langmuir isotherm was determined to be the most suitable model for the adsorption interaction
Citation - WoS: 22
Citation - Scopus: 22
Antioxidant Properties of Cultured Mycelia from Four Pleurotus Species Produced in Submerged Medium
(TAYLOR & FRANCIS INC, 2013) Dündar, Abdurrahman; Okumus, Veysi; Ozdemir, Sadin; Yildiz, Abdunnasir; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The ethanolic extracts of dried cultured mycelia of Pleurotus ostreatus, Pleurotus eryngii, Pleurotus florida, and Pleurotus sajor-caju were analyzed for antioxidant activity in different systems. Tests used are as follows: reducing power, free radical scavenging, superoxide anion radical scavenging, total antioxidant activity, metal chelating activitiy, etc.; total phenolic content was determined. The percentage inhibition of P. ostreatus, P. eryngii, P. florida, and P. sajor-caju at 20 mg/mL concentration on peroxidation in a -carotenelinoleic acid system was 57.19, 60.68, 62.12, and 58.81%, respectively. The reducing power of P. eryngii was higher than the other samples, and its value was 0.86 at 10 mg/mL concentration. P. ostreatus and P. sajor-caju proved to be better at scavenging superoxide anion radicals than the P. eryngii and P. florida. In the scavenging effect of DPPH radical test, P. ostreatus showed the highest activity potential and P. sajor-caju showed the strongest metal chelating capacity.
Citation - Scopus: 20
Antioxidant, anticancer and anticholinesterase activities of flower, fruit and seed extracts of hypericum amblysepalum HOCHST
(Asian Pacific Organization for Cancer Prevention, 2015) Keskin, Cumali; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background: Cancer is an unnatural type of tissue growth in which the cells exhibit unrestrained division, leading to a progressive increase in the number of dividing cells. It is now the second largest cause of death in the world. The present study concerned antioxidant, anticancer and anticholinesterase activities and protocatechuic, catechin, caffeic acid, syringic acid, p-coumaric acid and o-coumaric concentrations in methanol extracts of flowers, fruits and seeds of Hypericum amblysepalum. Materials and Methods: Antioxidant properties including free radical scavenging activity and reducing power, and amounts of total phenolic compounds were evaluated using different tests. Protocatechuic, catechin, caffeic acid, syringic acid, p-coumaric acid and o-coumaric concentrations in extracts were determined by HPLC. Cytotoxic effects were determined using the MTT test with human cervix cancer (HeLa) and rat kidney epithelium cell (NRK-52E) lines. Acetyl and butyrylcholinesterase inhibitory activities were measured by by Ellman method. Results: Total phenolic content of H. amblysepalum seeds was found to be higher than in fruit and flower extracts. DPPH free radical scavenging activity of the obtained extracts gave satisfactory results versus butylated hydroxyanisole and butylated hydroxytoluene as controls. Reducing power activity was linearly proportional to the studied concentration range: 10-500 µg/mL LC50 values for H. amblysepalum seeds were 11.7 and 2.86 respectively for HeLa and NRK-52E cell lines. Butyryl-cholinesterase inhibitory activity was 76.9 ± 0.41 for seed extract and higher than with other extracts. Conclusions: The present results suggested that H. amblysepalum could be a potential candidate anti-cancer drug for the treatment of human cervical cancer, and good source of natural antioxidants.
Citation - WoS: 3
Citation - Scopus: 3
Application of Half-Sandwich Metal-Phosphinite Compounds to Biological Activities: Determine the energies of the HOMO and LUMO levels
(Wiley Online Library, 2022) Dündar, Abdurrahman; Rafikova, Khadichakhan; Zazybin, Alexey; Güzel, Remziye; Kayan, Cezmi; Karakaş, Duygu Elma; Dündar, Abdurrahman; ISLAM, Sholpan; Okumuş, Veysi; Aydemir, Murat; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Mononuclear transition metal complexes 1-(furan-2-yl)ethyldiphenyl[dichloro(η6-p-cymene)ruthenium(II)]phosphinite, (2), 1-(furan-2-yl)ethyldiphenyl[dichloro(η6-benzene) ruthenium(II)] phosphinite (3), 1-(furan-2-yl)ethyldipheny[chloro(η4-1,5-cyclooctadiene)rhodium(I)]phosphinite (4), 1-(furan-2-yl)ethyldiphenyl[dichloro (η5pentamethylcyclopentadienyl)iridium (III)] phosphinite (5) were synthesized and characterized by microanalysis, infrared, MS, and NMR spectroscopy. The biological activities of the complexes were also tested. Compounds 2 and 5 were the best complexes at DPPH radical scavenging and reducing power activity at 73.27 % and 0.41 at 200 μg/mL, respectively. The highest antimicrobial activity exhibited by complex 3 as 14 mm inhibition zone against S. aureus. All of the complexes have cleaved the DNA from the double-strand and exhibited three bands on gel electrophoresis. Moreover, cyclic voltammetry studies of the phosphinite complexes were carried out to determine the energies of the HOMO and LUMO levels as well as to estimate their electrochemical and some electronic properties.
Asetonla Muamele Edilmiş Docetaxelin PC3 ve PNT1A Hücreleri Üzerindeki Sitotoksik Etkisi
(2021) Güngören, Muhammed; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Bu çalışmada, prostat kanserinin tedavisinde önemli bir kemoterapötik ajan olarak kullanılan docetaxelin, insan sağlam prostat hücresi (PNT1A) ve insan kanserli prostat hücresi (PC3) üzerindeki sitotoksik etkileri araştırılmıştır. Çalışmada ticari docetaxelin saf ve asetonda bekletilmiş formu kullanılmıştır. MTT [3-(4,5-dimetiltiazol-2-il)-2,5-difenil-2H-tetrazolyum bromid] testi kullanılarak 24, 48 ve 72 saatlik inkübasyon sonrası yapılan analizlerde farklı docetaxel formlarının kullanımı arasında anlamlı bir fark bulunmadığı tespit edilmiştir (p<0.01). Elde edilen bulgular, docetaxel formlarının PC3 ve PNT1A hücreleri üzerinde doza bağımlı sitotoksik etkilerinin varlığını ortaya koymaktadır. Sitotoksik etkinin doza bağımlılığının özellikle ilk 24 saatte oldukça yüksek olduğu belirlenmiştir (PC3 için p<0.05, PNT1A için p<0.01). 48. saatte saf docetaxelin PC3 hücresi için IC50 değeri 0.0116 μg/mL, PNT1A hücresi için IC50 değeri 3.5462 μg/mL olarak hesaplanmıştır. Bu değerler docetaxelin PNT1A hücrelerinde, PC3 hücrelerine kıyasla daha düşük olsada, sitotoksik etki oluşturduğunu göstermektedir. Direnç geliştirmiş prostat kanseri hücrelerinde de terapötik etkileri olan docetaxelin ilaç taşıma sistemleri ile beraber kullanılarak sağlam hücrelerdeki hasarının azaltılması uygun bir yaklaşım olarak düşünülmektedir.
Citation - WoS: 41
Citation - Scopus: 40
Association with Leptin Gene c.-2548 G > A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients
(HUMANA PRESS INC, 2013) Demir, Cemil; Say Şahin, Deniz; Demir, Cemil; Çelik, M. Murat; Çelik, Mustafa; Uçar, Edip; Güneşaçar, Ramazan; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Leptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (LEP), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether LEP c.-2548 G > A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction. LEP c.-2548 G > A polymorphism were detected using polymerase chain reaction-restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G > A polymorphism in the LEP were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %; p = 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (p < 0.001) and body mass index (p < 0.0001). All these consequences showed that LEP -2548 AA or AG genotypes are important predictors for increased levels of leptin and BMI in Turkish obese patients and it may be a useful marker for obesity risk in our population.
Citation - Scopus: 15
Basic Red 18 and Remazol Brilliant Blue R biosorption using Russula brevipes, Agaricus augustus, Fomes fomentarius
(Water Practice and Technology, 2022) Dündar, Abdurrahman; M’barek, Islem; Saleh, Mohammed; Isik, Zelal; Ozdemire, Sadin; Dündar, Abdurrahman; Dizge, Nadir; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
In this study, the adsorption abilities of Russula brevipes (RB), Agaricus augustus (AA), and Fomes fomentarius (FF) were evaluated in Basic Red 18 (BR18) and Remazol Brilliant Blue R (RBBR) biosorption from textile effluent. The adsorbents were characterized via Scanning Electron Microscopy (SEM), Energy Dispersive Spectrometer (SEM-EDS), and Fourier transform infrared spectroscopy (FT/IR). Fomes fomentarius presented a low sorption capacity contrary to the two other fungi (RB and AA). RB and AA were selected as potential adsorbents for BR18 and RBBR, respectively. The maximum BR18 removal efficiencies for 10, 25, and 50 mg/L were obtained after 60 min to be 90, 88, and 86%, respectively. The RBBR adsorption efficiencies were 96.4, 96, and 90% for dye concentrations of 10, 25, and 50 mg/L. The adsorption of BR18 onto the RB biomass followed the Freundlich isotherm, while Langmuir is the best isotherm for RBBR sorption’s elucidation onto AA fungus biomass. The removal of BR18 by BR biomass was found to follow the pseudo-second order. In contrast, the adsorption of RBBR onto the AA biomass followed Lagergren’s pseudo-first order. For both adsorbents, the adsorption was exothermic, feasible, and spontaneous in nature. Finally, the dyes’ biosorption process was perfectly achieved onto fungi biomass via physisorption
Citation - Scopus: 1
Biological assays, electrochemical behavior, and theoretical DFT calculations of Ru(II) complexes of chiral phosphinite based based on β-amino alcohols: Transfer hyrogenation of ketones using a HCOOH/Et3N mixture
(Elsevier, 2024) Dündar, Abdurrahman; Meriç, Nermin; Ertekin Binbay, Nil; Okumuş, Veysi; Sever, M. Şerif; Belyankova, Yelizaveta; Tursynbek, Saniya; Dauletbakov, Anuar; Sarah, Bayazit; Zolotareva, Darya; Yerassyl, Kamshyger; Dündar, Abdurahman; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Synthesis of two phosphinite ligands based on β-amino alcohols, in high yields has been demonstrated. When we treated [Ru(arene)(μ-Cl)Cl]2 {arene:p-cymene,benzene} with chelating phosphinite ligands, we obtained neutral Ru(II)-complexes possessing the general formula [Ru(arene)phosphiniteCl2]. The structure of the ligands and complexes was confirmed using analytical and spectroscopic techniques. The quantum chemical calculations were carried out for the ruthenium complexes at the DFT/CAM-B3LYP level of theory in gas phase. The phosphinite complexes were subjected to cyclic voltammetry studies in order to determine the energies of HOMO and LUMO levels and to estimate their electrochemical and some electronic properties. Organic complex-based memory substrates were immobilized using TiO2-modified ITO electrodes, and the memory functions of phosphinite-based organic complexes were verified by chronoamperometry (CA) and open-circuit potential amperometry (OCPA). In the present study, the antioxidant potentials of ruthenium-based p-cymene and benzene complexes through DPPH radical scavenging, metal chelating, and reducing power activities were also determined. In addition, DNA binding abilities and antimicrobial activities of these complexes against pathogenic bacteria were studied. Finally, the ruthenium complex, (2S)-1-{[(2S)-2-[(diphenylphosphanyl)oxy]propyl][(1R)-1-phenylethyl]amino}propan-2-yldiphenyl phosphinitobis[dichloro(η6-benzene)ruthenium(II)] also catalyzed asymmetric transfer hydrogenation of acetophenone with high conversion (up to 99%) and good enantioselectivity (ee up to 89 %), in the existence of formic acid and triethylamine in dichloromethane medium under air atmosphere.
Citation - WoS: 22
Citation - Scopus: 25
Biosorption of chlorophenoxy acid herbicides from aqueous solution by using low-cost agricultural wastes
(TAYLOR & FRANCIS INC, 2015) Dündar, Abdurrahman; Celik, K. Serdar; Kılınç, Ersin; Dundar, Abdurrahman; Kilinc, Ersin; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The potential biosorption abilities of apple shell (AS), orange peel (OP), banana peel (BP), and millet waste (MW) as a bio-waste material to remove 2,4-dichlorophenoxy acetic acid (2,4-D), 2,4-dichlorophenoxy propanoic acid (2,4-DP), and 2,4-dichlorophenoxy butyric acid (2,4-DB) from aqueous solution were investigated in batch condition. Optimum biosorption conditions were determined as a function of contact time, pH of the solution, amount of biomass, and initial pesticide concentrations. The concentrations of the pesticides in the remaining solutions were simultaneously determined by high performance thin layer chromatography. Langmuir and Freundlich models were applied to describe the biosorption isotherm of the pesticides by agricultural wastes. The experimental adsorption data were fitted to Langmuir adsorption models (r(2)>0.99). It was found that adsorption of 2,4-DP was higher for all biosorbent. The highest maximum adsorption capacities of 2,4-DP were found as 40.08, 22.71, 33.26, and 45.45mg/g, respectively, for AS, OP, BP, and MW. Maximum adsorption capacity was obtained for 2,4-D as OP>MW>BP>AS, 2,4-DP as MW>AS>BP>OP, and 2,4-DB as OP>AS>BP>MW. From the results, it can be said that MW was an effective biosorbent for removal of 2,4-DP and OP was an effective biosorbent for removal of 2,4-D and 2,4-DB through the studied pesticides. Optimum biosorption conditions were determined as 60min of contact time, 100mg of biomass, AS at pH 6.0, OP at pH 6.0, MW at pH 7.0, and BP at pH 7.0. FT-IR was employed to understand the surface properties of biosorbents. According to the results, agricultural wastes have high adsorption capacity.
Citation - Scopus: 15
Biosorption Studies of Mushrooms for Two Typical Dyes
(Journal of the Turkish Chemical Society, Section A: Chemistry, 2020) Yıldırım, Ayfer; Acay, Hilal; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
This study investigated the adsorption behaviour of two cationic dyes, methylene blue (MB) and malachite green (MG) onto Pleurotus ostreatus, Armillaria tabescens, and Morchella conica mushrooms. The effects of contact time, initial dye concentration, and solution pH (3-11) were also determined. The adsorption on all mushrooms attained equilibrium within 120 min for both MB and MG. To evaluate the experimental kinetics data, the pseudo-first-order, pseudo-second-order, and intraparticle diffusion kinetics equations were utilised. The pseudo-first-order kinetic model demonstrated a good fit with all adsorption kinetics. The Langmuir and Freundlich isotherm models were used to analyse the mechanism of the adsorption isotherm. The adsorption equilibrium isotherm was in a good agreement with the Freundlich model. Thermodynamic parameters such as ΔH enthalpy variation, ΔS entropy variation, and ΔG free Gibbs energy variation were calculated at 303-323 K. The results suggested that the Pleurotus ostreatus mushroom was the most suitable adsorbent for both cationic dyes’ removal.
Citation - WoS: 60
Citation - Scopus: 76
Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract
(Elsevier, 2023) Keskin, Cumali; Baran, Ayşe; Baran, Mehmet Fırat; Keskin, Cumali; Baran, Ayşe; Baran, Mehmet Fırat; Eftekhari, Aziz; Aytuğ Ava, Canan; İrtegün Kandemir, Sevgi; Cebe, Deniz Barış; Dağ, Beşir; Beilerli, Aferin; Khalilov, Rovshan; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Metallic nanoparticle biosynthesis is thought to offer opportunities for a wide range of biological uses. The green process of turning biological waste into utilizable products gaining attention due to its economical and eco-friendly approach in recent years. This study reported the ability of Solanum tuberosum (ST) peel extract to the green synthesis of non-toxic, stable, small-sized silver nanoparticles without any toxic reducing agent utilizing the phytochemical components present in its structure. UV-visible spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, flourier scanning electron microscopy, atomic force microscopy, transmission electron microscopy, and energy dispersive analysis X-ray confirmed the biosynthesis and char-acterization of silver nanoparticles. Also, dynamic light scattering and thermogravimetric ana-lyses showed stable synthesized nanoparticles. The antibacterial activity of the biosynthesized silver nanoparticles was evaluated against four different bacterial strains, Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) Bacillus subtilis (B. subtilis), and a yeast, Candida albicans (C. albicans) using the minimum inhibitory concen-tration technique. The cytotoxic activities were determined against Human dermal fibroblast (HDF), glioblastoma (U118), colorectal adenocarcinoma (CaCo-2), and human ovarian (Skov-3) cell lines cancer cells using MTT test. The nanoparticle capping agents that could be involved in the reduction of silver ions to Ag NPs and their stabilization was identified using FTIR. Nano -particles were spherical in shape and had a size ranging from 3.91 to 27.07 nm, showed crys-talline nature, good stability (-31.3 mV), and the presence of capping agents. ST-Ag NPs significantly decreased the growth of bacterial strains after treatment. The in vitro analysis showed that the ST-Ag NPs demonstrated dose-dependent cytotoxicity against cell lines. Based on the data, it is feasible to infer that biogenic Ag NPs were capped with functional groups and demonstrated considerable potential as antibacterial and anticancer agents for biomedical and industrial applications.
Citation - WoS: 22
Citation - Scopus: 24
Boletus edulis loaded with gamma-Fe2O3 nanoparticles as a magnetic sorbent for preconcentration of Co(II) and Sn(II) prior to their determination by ICP-OES
(SPRINGER WIEN, 2018) Kılınç, Ersin; Yalçın, M. Serkan; Kılınç, Ersin; Soylak, Mustafa; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The authors show that the fungus Boletus edulis loaded with gamma-Fe2O3 nanoparticles is a viable sorbent for magnetic solid phase extraction of trace levels of Co(II) and Sn(II). The surface structure of immobilized magnetized B. edulis was characterized by FT-IR, SEM and EDX. Experimental parameters were optimized. Following elution with 1 M HCl, the ions were quantified by ICP-OES. The limits of detection are 21 pg.mL(-1) for Co(II), and 19 pg.mL(-1) for Sn(II). The preconcentration factors are 100 for both ions. The sorption capacities of the sorbent are 35.8 mg.g(-1) for Co(II) and 29.6 mg.g(-1) for Sn(II). The method was applied to the analysis of certificated reference materials and gave >= 95% recoveries with low RSDs. It was also successfully applied to the quantification of Co(II) and Sn(II) in spiked environmental and food samples.
BOR NİTRÜR VE TÜREVLERİNİN BİYOMEDİKAL ALANDA UYGULAMALARI
(2022) Tarhan, Tuba; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Bor nitrür (BN), eşit sayıda bor ve nitrojen atomundan oluşan kovalent bir katıdır. Sergilediği olağanüstü özellikler sayesinde oldukça dikkat çekmiş ve çığır açacak yeni uygulamalar için beklentileri artırmıştır. Yapısal olarak karbon sistemine benzeyen BN'ler dört farklı poli kiristal formda bulunur: grafit benzeri altıgen BN (h-BN), eşkenar dörtgen (r-BN), elmas benzeri kübik BN (c-BN) ve wurtzite BN (w-BN) (1-3). Özellikle h-BN, iki boyutlu (2D) katmanlı yapı sunan standart koşullar altında en kararlı BN fazıdır. Bor atomları için sp2 hibridizasyonu gözlemlenir ve B-N-B veya N-B-N arasında beklenen bağ açısı 120˚ olup, grafit gibi mükemmel bir altıgen halka bağ ağı oluştururken, 2D katmanlar zayıf van der Waals kuvvetleri tarafından bir arada tutulur (2,4,5). BN nanomalzemeleri, nanoküreler, nanotüpler (BNNT), nanolifler, nanofulleren (BNFL), kuantumdot (BNQD) nanoşeritler (BNNR), ince filmler ve nanolevhalar (BNNS) gibi tüm morfolojik şekillerde bulunabilir (Şekil 1) (6,7).İlgi çekici kimyasal, fiziksel ve biyolojik özelliklerinden dolayı bor nitrür, bilimsel ve teknolojik topluluklar tarafından büyük ilgi görmüştür (4). BN malzemeleriyle ilgili yayınların sayısı son on yılda çarpıcı bir biçimde arttmıştır (bkz. Şekil 2a). Şekil 2b, 2019'daki BN materyallerinin yayın durumunu göstermektedir: yaklaşık %50'si nanomalzemelerle ilgilidir ve hem BNNT'ler hem de BNNS'ler üzerine yapılan araştırmalar yaklaşık %20'sini oluşturmaktadır. Bu raporlara göre BN sistemleri optoelektronik cihazlar (1,8,9), kuantum yayıcılar (1,10,11), yarı iletkenler (1,12), enerji depolama (1,13), termal iletkenler (1,14), kozmetik ürünler (1,15), su temizleme (1,16,17), fotokatalitik (1,18) ve ayrıca biyomedikal bilimi (1,19) vb. üzerine yapılan çalışmalar ile ilgili verileri içermektedir (1).Bu bölümde, odak noktasının in vivo ve in vitro olduğu, bor nitrürün kedisi, türevleri, bir kaplama malzemesi veya kompozit halinin biyouyumluluğu ve anti-bakteriyel özelliklerinden dolayı biyomedikal uygulamalarda kullanılabilme potansiyelleri araştırılıyor. Bor nitrür, ilaç dağıtımı, görüntüleme ve hücre stimülasyonu gibi tıbbi alanlarda bazı uygulamalar için yeni bir kapı açacaktır (20). Ayrıca, BN nanoparçacıkları van der Waals, hidrofilik, hidrofobik, hidrojen bağı ve π-π etkileşimleri gibi moleküller arası etkileşimlerin yanı sıra kovalent olmayan etkileşimler ile işlevselleştirilebilmesi sayesinde, konakçı sistemlere güçlü bir şekilde bağlanır (4,21). Moleküllerin sahip olduğu bu fiziksel etkileşimlerin (konjuge, yüzey aktif maddeler vb.) avantajlarını kullanarak kontrollü fizikokimyasal özellikleri ile farklı ortamlara homojen bir şekilde dağılırlar (4, 22). Literatürde, selüloz filmler veya lifler (4,23,24), kitosan (4,25), polietilenimin aşılanmış nanoşerit (mikro RNA'nın tanınması için) (4,26), vinil asetat kopolimeri (4,22), oktadesilamin (4,27), glukoz oksidaz biyoalgılama (4,28), poli (etilen glikol) (4,29), DNA (4,30) ve metalik nanopartiküller gibi farklı nanoparçacıkları içeren kovalent ve kovalent olmayan çeşitli işlevselleştirme metodolojileri sunulmuştur (4). Bu bileşiklerin başarısı ve performansı için en önemli konu, her türlü inorganik veya biyolojik sistem için en uygun işlevselleştirme sürecinin (biyo-nanomühendislik) seçimidir (4). Fiziksel-kimyasal modifikasyonlar ve uygulamaları için en önemli adım, nanokompleksin kimyasal olarak kararlı, iyi dağılmış ve ilgili biyolojik ortamla uyumlu olmasıdır. Böylece tanı ve tedavi amaçlı ekolojik paketleme, biyo-robotlar, tümör belirteçleri gibi biyoteknoloji ve biyomedikal alanlarda gelişmiş uygulamalara sahip akıllı nano sistemler üretilebilmektedir (4). Bu bölümde, bor nitrürün işlevselleştirilmesinin ana yöntemleri, bunların biyoteknoloji ve nanotıp alanındaki gelişmeleri ve potansiyel uygulamaları hakkında kısa bir rapor sunuyoruz.
Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats
(2018) Çetik Yıldız, Songül; KESKİN, Cumali; Sahinturk, Varol; Ayhanci, Adnan; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
ABSTRACT: Cyclophosphamide (CYP) is commonly used as anticancer agent but its usage is limited by cardiotoxic side effects such as dose-dependent cardiac damage, morphologically defined necrosis and bleeding. Hypericum triquetrifolium Turra. (HT) shows anti-oxidative and anticarciogenic properties with its rich phenolic contents. The current study was designed to investigate the possible protective effect of HT on CYP-induced cardiotoxicity. Albino rats were randomly divided into 9 groups, each included 7 animals. Serum creatine kinase-MB (CK-MB), malondialdehyde (MDA), aspartate transaminase (AST), glutathione (GSH), total antioxidant (TAC) and total oxidant capacity (TOC) levels were investigated. Furthermore, the cardiac tissue samples were investigated histopatologically. While the levels of serum CK-MB, MDA, AST and TOC were high, the levels of serum GSH and TAC levels were low in the CYP groups. It was also observed that CYP-induced cardiotoxicity was dose dependent. In the treatment with CYP plus HT doses there was observed an essential decrease in the CYP cardiotoxicity; decreased cell damage and oxidative stress parameters and also increased GSH and TAC levels. Based on our findings, it can be proposed that HT seed methanol extract was a strong candidate in preventing the CYP-induced cardiotoxicity.
Citation - WoS: 8
Citation - Scopus: 3
Cardioprotectiveeffectsof Hypericumtriquetrifoliumturra. Against Cyclophosphamide Related Cardiotoxicity in Rats
(2018) Çetik Yıldız, Songül; Keskin, Cumali; Ayhanci, Adnan; Şahintürk, Varol; Yıldız, Songul Cetık; Keskin, Cumali; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Cyclophosphamide (CYP) is commonly used as anticancer agent but its usage is limited by cardiotoxic side effects such as dose-dependent cardiac damage, morphologically defined necrosis and bleeding. Hypericum triquetrifoliumTurra. (HT) shows anti-oxidative and anticarciogenic properties with its rich phenolic contents. The current study was designed to investigate the possible protective effect of HT on CYP-induced cardiotoxicity. Albino ratswererandomlydividedinto9groups,eachincluded7animals.Serumcreatinekinase-MB(CK-MB), malondialdehyde (MDA), aspartate transaminase (AST), glutathione (GSH), total antioxidant (TAC) and total oxidant capacity (TOC) levels were investigated. Furthermore, the cardiac tissue samples were investigated histopatologically. While the levels of serum CK-MB, MDA, AST and TOC were high, the levels of serum GSH and TAC levels were low in the CYP groups. It was also observed that CYP-induced cardiotoxicity was dose dependent. In the treatment with CYP plus HT doses there was observed an essential decrease in the CYP cardiotoxicity; decreased cell damage and oxidative stress parameters and also increased GSH and TAC levels. Based on our findings, it can be proposed that HT seed methanol extract was a strong candidate in preventing the CYP-induced cardiotoxicity.
Citation - WoS: 1
Citation - Scopus: 1
Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension
(Arquivos de Neuro-Psiquiatria, 2022) Dündar, Ahmet; Arıkanoğlu, Adalet; Özdemir, Hasan Hüseyin; Aslanhan, Hamza; Çevik, Mehmet Uğur; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleukin-33 (IL-33) are among the factors involved in inflammatory processes. Objective To investigate the CSF levels of sortilin-1, lipocalin-2, autotaxin, decorin, and IL-33 in patients with IIH. Methods A total of 24 IIH patients and 21 healthy controls were included in the study. Demographic characteristics of the patients and of the control group as well as CSF pressures were evaluated. Sortilin-1, lipocalin-2, autotaxin, decorin and IL-33 levels in the CSF were measured. Results The CSF levels lipocalin-2, sortilin-1, autotaxin, IL-33 and CSF pressure were significantly higher in the patients group compared with the control group (p < 0.001). Decorin levels were reduced in patients (p < 0.05). There was no correlation between the autotaxin and IL-33 levels and age, gender, CSF pressure, and body mass index. The results of our study showed that inflammatory activation plays an important role in the development of the pathophysiology of IIH. In addition, the fact that the markers used in our study have never been studied in the etiopathogenesis of IIH is important in explaining the molecular mechanism of this disease. Conclusion Studies are needed to evaluate the role of these cytokines in the pathophysiology of the disease. It is necessary to evaluate the effects of these molecules on this process. © 2022. Academia Brasileira de Neurologia. All rights reserved.

Browse

Browsing Sağlık Hizmetleri Meslek Yüksekokulu by Author "21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü"