Browsing by Author "Dündar, Abdurrahman"

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Citation - WoS: 0
Analysis of legionella and Some Chemicals in Water Samples in Mardin Province
(Kahramanmaras Sutcu Imam Univ Rektorlugu, 2022) Dündar, Abdurrahman; Yildirim, Idris; Dundar, Nagihan Demir; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
In this study microbiological and chemical analyzes were carried out on water and swab samples taken from two water wells, a water tank and taps of buildings belonging to a public institution in Mardin Province. In these specimens the presence of Legionella and its serogroups as well as the parameters such as chlorine, nitrate, nitrite concentration, pH level and electrical conductivity were analyzed. While Legionella growth was not observed in 25 water samples, L. pneumophila serogroup 1 was detected in 4 of 25 swab culture samples taken from the same places. The pH values of water samples ranged from 7.53 to 8.02 the lowest pH value was observed in well no 1 as 7.53 while the highest was observed in well no 2 as 8.02. The lowest electrical conductivity value was measured at well 2 as 376.44 mu S cm(-1) and the highest was measured as 446.57 mu S/cm from well 1. As a result of the analyzes made in our research nitrite was not detected in any of the water samples. Whilst the nitrate amount was found to be the lowest with 4.30 ppm in the well, the highest with 10.85 ppm in the well 2. The chlorine values in the well 1 and 2 from which water samples were taken and the main tank were measured as 2.21, 2.05 and 2.43 ppm respectively. These values were found to be in the range of 1.68-1.73 ppm in the samples taken from the building taps.
Citation - WoS: 11
Citation - Scopus: 11
Anoxybacillus sp. SO B1-Immobilized Amberlite XAD-16 for Solid-Phase Preconcentration of Cu(II) and Pb(II) and Their Determinations by Flame Atomic Absorption Spectrometry
(TAYLOR & FRANCIS INC, 2015) Dündar, Abdurrahman; Ozdemir, Sadin; Dolak, Ibrahim; Okumus, Veysi; Dundar, Abdurrahman; Ziyadanogullari, Berrin; Aksoy, Zehra; Onat, Ruken; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
A new method for the determination of Cu(II) and Pb(II) by flame atomic absorption spectrometry (FAAS) after preconcentrating on a column containing Anoxybacillus sp. SO B1-immobilized Amberlite XAD-16 was developed. The functional groups of Anoxybacillus sp. SO B1 immobilized on Amberlite XAD-16 were characterized in KBr tablets by Fourier transform infrared (FT-IR) spectrometry. Various parameters such as pH, amount of the adsorbent, eluent type and volume, and flow rate of the sample solution were studied. The optimum pH values of quantitative sorption for Cu(II) and Pb(II) were found to be pH 7.0 and 5.0 and Cu(II) and Pb(II) ions could be quantitatively eluted with 5.0ml of 1.0mol L-1 HCI and 10.0ml of 0.25mol L-1 HNO3, respectively. Recoveries of Cu(II) and Pb(II) were found to be 100.9 +/- 1.57% and 100.3 +/- 0.49% (N = 5), the limits of detection of Cu(II) and Pb(II) in the determination by FAAS (3s, N = 10) were found to be 0.8 and 1.6 mu g L-1, respectively. The proposed enrichment method was applied for metal ion determination from water samples such as two parts of Tigris River water in Diyarbakir and Elazig, Lake of Hazar in Elazig, and tap water in Diyarbakir. Furthermore, the accuracy of the proposed method was verified by studying the analytical recovery and by analyzing certified reference material (NCS-DC 73350 leaves of poplar).
Citation - WoS: 22
Citation - Scopus: 22
Antioxidant Properties of Cultured Mycelia from Four Pleurotus Species Produced in Submerged Medium
(TAYLOR & FRANCIS INC, 2013) Dündar, Abdurrahman; Okumus, Veysi; Ozdemir, Sadin; Yildiz, Abdunnasir; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The ethanolic extracts of dried cultured mycelia of Pleurotus ostreatus, Pleurotus eryngii, Pleurotus florida, and Pleurotus sajor-caju were analyzed for antioxidant activity in different systems. Tests used are as follows: reducing power, free radical scavenging, superoxide anion radical scavenging, total antioxidant activity, metal chelating activitiy, etc.; total phenolic content was determined. The percentage inhibition of P. ostreatus, P. eryngii, P. florida, and P. sajor-caju at 20 mg/mL concentration on peroxidation in a -carotenelinoleic acid system was 57.19, 60.68, 62.12, and 58.81%, respectively. The reducing power of P. eryngii was higher than the other samples, and its value was 0.86 at 10 mg/mL concentration. P. ostreatus and P. sajor-caju proved to be better at scavenging superoxide anion radicals than the P. eryngii and P. florida. In the scavenging effect of DPPH radical test, P. ostreatus showed the highest activity potential and P. sajor-caju showed the strongest metal chelating capacity.
Citation - WoS: 3
Citation - Scopus: 3
Application of Half-Sandwich Metal-Phosphinite Compounds to Biological Activities: Determine the energies of the HOMO and LUMO levels
(Wiley Online Library, 2022) Dündar, Abdurrahman; Rafikova, Khadichakhan; Zazybin, Alexey; Güzel, Remziye; Kayan, Cezmi; Karakaş, Duygu Elma; Dündar, Abdurrahman; ISLAM, Sholpan; Okumuş, Veysi; Aydemir, Murat; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Mononuclear transition metal complexes 1-(furan-2-yl)ethyldiphenyl[dichloro(η6-p-cymene)ruthenium(II)]phosphinite, (2), 1-(furan-2-yl)ethyldiphenyl[dichloro(η6-benzene) ruthenium(II)] phosphinite (3), 1-(furan-2-yl)ethyldipheny[chloro(η4-1,5-cyclooctadiene)rhodium(I)]phosphinite (4), 1-(furan-2-yl)ethyldiphenyl[dichloro (η5pentamethylcyclopentadienyl)iridium (III)] phosphinite (5) were synthesized and characterized by microanalysis, infrared, MS, and NMR spectroscopy. The biological activities of the complexes were also tested. Compounds 2 and 5 were the best complexes at DPPH radical scavenging and reducing power activity at 73.27 % and 0.41 at 200 μg/mL, respectively. The highest antimicrobial activity exhibited by complex 3 as 14 mm inhibition zone against S. aureus. All of the complexes have cleaved the DNA from the double-strand and exhibited three bands on gel electrophoresis. Moreover, cyclic voltammetry studies of the phosphinite complexes were carried out to determine the energies of the HOMO and LUMO levels as well as to estimate their electrochemical and some electronic properties.
Assessment Of The Antimicrobial, Antioxidant And Cytotoxic Activities Of The Wild Edible Mushroom Pleurotus Eryngii From Hakkari, Turkey
(2017) Acay, Hilal; Dündar, Abdurrahman; Keskin, Cumali; Kaçar, Semra; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Abstract: Mushroom is an important source of natural compounds with acknowledged bioactivity. Pleurotus eryngii, in particular, is widely recognized for its organoleptic quality and favorable healthy effects, being commercially produced in great extent. The present study is just for evaluating the antioxidant capacity (scavenging DPPH radicals, reducing power, Total antioxidant activity by β-carotene-linoleic acid metod, Chelating effect on ferrous ions, superoxide anion radical scavenging activity ), antimicrobial effects (by using the disc diffusion method) and insufficiently studied cytotoxic activity (using PC-3 cell lines) of Pleurotus eryngii by using various solvent systems. For this reason; obtained extracts of the mushroom applying hexane, ethylacetate and methanol respectively were tested with in its biologic activities. As a result, The highest total antioxidant activity by β -carotene-linoleic acid metod was identified in methanol extract (63.62 mg /ml). The highest DPPH scavenging activity was obtained from ethyl acetate extract with 88.81 mg/ml. EDTA is used as standard in methal chelating activity. The highest metal chelating activity of Pleurotus eryngii identified in hexane (88,1 mg /ml) and ethylacetate (88.84 mg /ml) extracts. Additionally, in most of studied tests antioxidant activity of the mushroom increased with increasing concentration. On the other hand, the highest antimicrobial activity was obtained against Pseudomonas aeruginosa ATCC 27853 (11 mm) in ethyl acetate extract. However, the best antimicrobial activities were observed in hexane and methanol extracts for other tested microorganism. It was not determined any antimicrobial activity against Escherichia coli ATCC 25922. It has been found that the potential of cytotoxic activity is depended on concentration and solvent type of extracts. Ethyl acetate extract showed significant inhibitory value at the concentrations of 530 µg/ml (86.20 %) against PC-3 cell lines. Using methanol extract, the maximun inhibition was observed at concentration of 680 µg/ml with value of 51.86 %. Overall, the mushroom used as a daily nutrient could be a source for new drug developments and a kind of treatment in cancer therapies, and also, organic extracts of Pleurotus eryngii may contain substances that stimulate bioactivity
Citation - Scopus: 13
Basic Red 18 and Remazol Brilliant Blue R biosorption using Russula brevipes, Agaricus augustus, Fomes fomentarius
(Water Practice and Technology, 2022) Dündar, Abdurrahman; M’barek, Islem; Saleh, Mohammed; Isik, Zelal; Ozdemire, Sadin; Dündar, Abdurrahman; Dizge, Nadir; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
In this study, the adsorption abilities of Russula brevipes (RB), Agaricus augustus (AA), and Fomes fomentarius (FF) were evaluated in Basic Red 18 (BR18) and Remazol Brilliant Blue R (RBBR) biosorption from textile effluent. The adsorbents were characterized via Scanning Electron Microscopy (SEM), Energy Dispersive Spectrometer (SEM-EDS), and Fourier transform infrared spectroscopy (FT/IR). Fomes fomentarius presented a low sorption capacity contrary to the two other fungi (RB and AA). RB and AA were selected as potential adsorbents for BR18 and RBBR, respectively. The maximum BR18 removal efficiencies for 10, 25, and 50 mg/L were obtained after 60 min to be 90, 88, and 86%, respectively. The RBBR adsorption efficiencies were 96.4, 96, and 90% for dye concentrations of 10, 25, and 50 mg/L. The adsorption of BR18 onto the RB biomass followed the Freundlich isotherm, while Langmuir is the best isotherm for RBBR sorption’s elucidation onto AA fungus biomass. The removal of BR18 by BR biomass was found to follow the pseudo-second order. In contrast, the adsorption of RBBR onto the AA biomass followed Lagergren’s pseudo-first order. For both adsorbents, the adsorption was exothermic, feasible, and spontaneous in nature. Finally, the dyes’ biosorption process was perfectly achieved onto fungi biomass via physisorption
Bazı makrofungusların fenolik içerikleri ile antioksidan ve antimikrobiyal potansiyellerinin araştırılması
(Mardin Artuklu Üniversitesi, 2022) Dündar, Abdurrahman; Dündar, Abdurrahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Bu çalışmada 2012-2013 yılları ilkbahar ve sonbahar mevsimlerinde Siirt ve çevresinde toplanan Phallus impudicus, Coprinus silviaticus ile Morchella tomentosa, Amanita fulva adlı makro mantar türlerinin etanol ekstraktlarının bazı fenolik asit içerikleri ile antioksidan ve antimikrobiyal potansiyelleri çalışılmıştır. Söz konusu makro mantarların etanol ekstraktlarının antioksidan potansiyellerinin tespiti amacıyla; DPPH serbest radikal yakalama, metal iyonlarını şelatlama, indirgeme gücü ve süperoksit anyon radikal süpürme testleri uygulanmıştır. Antimikrobiyal aktivitenin belirlenmesi amacıyla da disk difüzyon yöntemi çalışılmıştır. Süperoksit anyon radikal aktivitesinde tespit edilen en yüksek değer % 83,24 ile Morchella tomentosa en düşük değer ise % 73,05 ile Coprinus silviaticus'a ait bulundu. DPPH serbest radikalini söndürme aktivite tekniğinde en fazla etkinliği gösteren Amanita fulva etanolik ekstraktının 1.0, 2.0, 5.0, 10.0, 15.0, 20.0 mg/mL konsantrasyonlardaki etkinlik verilerinin sırasıyla %19.33, %24.46, %58.74, %77.75, %87.89, %88.40 olduğu tespit edilmiştir. Metal şelatlama etkinliğinde kullanılan ekstraktların ve pozitif kontrol olarak çalışılan standartların etkinlik sıralaması EDTA> Amanita fulva> Morchella tomentosa> Phallus impudicus> Coprinus silviaticus> BHT> BHA> Trolox şeklinde tespit edilmiştir. Mantar indirgeme gücü aktivitesinde ise 10.0 mg/mL konsantrasyonda 2,89 aktivite ile en yüksek etkinliği gösteren mantar Morchella tomentosa olarak gözlenmiştir. Antimikrobiyal aktivite testinde ise Enterococcus hirae hariç diğer beş bakteriye karşı en yüksek inhibisyon zonlarını M. tomentosa'nın etanol ekstraktı sergilemiştir.
Citation - WoS: 0
Citation - Scopus: 1
Biological assays, electrochemical behavior, and theoretical DFT calculations of Ru(II) complexes of chiral phosphinite based based on β-amino alcohols: Transfer hyrogenation of ketones using a HCOOH/Et3N mixture
(Elsevier, 2024) Dündar, Abdurrahman; Meriç, Nermin; Ertekin Binbay, Nil; Okumuş, Veysi; Sever, M. Şerif; Belyankova, Yelizaveta; Tursynbek, Saniya; Dauletbakov, Anuar; Sarah, Bayazit; Zolotareva, Darya; Yerassyl, Kamshyger; Dündar, Abdurahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Synthesis of two phosphinite ligands based on β-amino alcohols, in high yields has been demonstrated. When we treated [Ru(arene)(μ-Cl)Cl]2 {arene:p-cymene,benzene} with chelating phosphinite ligands, we obtained neutral Ru(II)-complexes possessing the general formula [Ru(arene)phosphiniteCl2]. The structure of the ligands and complexes was confirmed using analytical and spectroscopic techniques. The quantum chemical calculations were carried out for the ruthenium complexes at the DFT/CAM-B3LYP level of theory in gas phase. The phosphinite complexes were subjected to cyclic voltammetry studies in order to determine the energies of HOMO and LUMO levels and to estimate their electrochemical and some electronic properties. Organic complex-based memory substrates were immobilized using TiO2-modified ITO electrodes, and the memory functions of phosphinite-based organic complexes were verified by chronoamperometry (CA) and open-circuit potential amperometry (OCPA). In the present study, the antioxidant potentials of ruthenium-based p-cymene and benzene complexes through DPPH radical scavenging, metal chelating, and reducing power activities were also determined. In addition, DNA binding abilities and antimicrobial activities of these complexes against pathogenic bacteria were studied. Finally, the ruthenium complex, (2S)-1-{[(2S)-2-[(diphenylphosphanyl)oxy]propyl][(1R)-1-phenylethyl]amino}propan-2-yldiphenyl phosphinitobis[dichloro(η6-benzene)ruthenium(II)] also catalyzed asymmetric transfer hydrogenation of acetophenone with high conversion (up to 99%) and good enantioselectivity (ee up to 89 %), in the existence of formic acid and triethylamine in dichloromethane medium under air atmosphere.
Citation - WoS: 22
Citation - Scopus: 25
Biosorption of chlorophenoxy acid herbicides from aqueous solution by using low-cost agricultural wastes
(TAYLOR & FRANCIS INC, 2015) Dündar, Abdurrahman; Celik, K. Serdar; Kılınç, Ersin; Dundar, Abdurrahman; Kilinc, Ersin; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The potential biosorption abilities of apple shell (AS), orange peel (OP), banana peel (BP), and millet waste (MW) as a bio-waste material to remove 2,4-dichlorophenoxy acetic acid (2,4-D), 2,4-dichlorophenoxy propanoic acid (2,4-DP), and 2,4-dichlorophenoxy butyric acid (2,4-DB) from aqueous solution were investigated in batch condition. Optimum biosorption conditions were determined as a function of contact time, pH of the solution, amount of biomass, and initial pesticide concentrations. The concentrations of the pesticides in the remaining solutions were simultaneously determined by high performance thin layer chromatography. Langmuir and Freundlich models were applied to describe the biosorption isotherm of the pesticides by agricultural wastes. The experimental adsorption data were fitted to Langmuir adsorption models (r(2)>0.99). It was found that adsorption of 2,4-DP was higher for all biosorbent. The highest maximum adsorption capacities of 2,4-DP were found as 40.08, 22.71, 33.26, and 45.45mg/g, respectively, for AS, OP, BP, and MW. Maximum adsorption capacity was obtained for 2,4-D as OP>MW>BP>AS, 2,4-DP as MW>AS>BP>OP, and 2,4-DB as OP>AS>BP>MW. From the results, it can be said that MW was an effective biosorbent for removal of 2,4-DP and OP was an effective biosorbent for removal of 2,4-D and 2,4-DB through the studied pesticides. Optimum biosorption conditions were determined as 60min of contact time, 100mg of biomass, AS at pH 6.0, OP at pH 6.0, MW at pH 7.0, and BP at pH 7.0. FT-IR was employed to understand the surface properties of biosorbents. According to the results, agricultural wastes have high adsorption capacity.
COVID-19 tanısı konan hastaların cinsiyet ve yaş faktörlerinin bazı biyokimyasal değerlerle korelâsyonunun araştırılması
(Mardin Artuklu Üniversitesi, 2022) Dündar, Abdurrahman; Dündar, Abdurrahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
2019 yılının son döneminde Wuhan şehrinde ortaya çıkan Covid-19 hastalığı çok hızlı bir şekilde dünyaya yayılış göstermiş ve kısa bir süre sonra ülkemizde görülmeye başladı. Covid-19 ile ilgili önemli çalışmalar yapılmakta bu virüs ve benzeri virüs kökenli hastalıkların tespiti ve erken teşhisi ile tedavi amaçlı Crp, Lym, Ferritin, Kan Gazı ve D-dimer gibi bazı biyokimyasal değerlerin düzeylerinin hastalık şiddeti ve diğer biyokimyasal değerler ile ilişkisini değerlendirilmesi ve bu biyokimyasal değerlerin yaş, cinsiyet üzerindeki etkilerini değerlendirmeyi amaçladık. Yaptığımız çalışmada, hasta dosyalarının retrospektif incelenmesine dayalı kesitsel ve tanımlayıcı bir çalışmadır. 01 Haziran 2020 ile 30 Mayıs 2021 tarihleri arasında Kızıltepe devlet hastanesine başvuran ve hastalık tanısı konulan 12 aylık süreçte hastaların Crp, Lym, Ferritin, Kan Gazı ve D-dimer gibi bazı biyokimyasal değerleri ve aynı zamanda bu değerlerin diğer biyokimyasal değerler arasındaki ilişki ile bu değerlerin yaş ve cinsiyete olan etkileri incelendi ve analizleri yapıldı. Araştırma da elde edilen veriler SPSS for Windows 25.0 programı kullanılarak analiz edilmiştir. Verileri değerlendirilirken tanımlayıcı istatistiksel metotları (sayı, yüzde, ortalama, standart sapma) kullanılmıştır. Çalışmamız da inceleyeceğimiz tüm parametreleri eksiksiz olan 01 Haziran 2020 ile 30 Mayıs 2021 tarihleri arasında Kızıltepe devlet hastanesine başvuran ve COVID-19 tanısı koyulan 1812 hasta dahil edildi. Bu hastalardan %51,9'u (n: 941) kadın % 48,1 (n: 871) erkektir. Ve yaş ortalaması 56,58±19,89 olarak hesaplanmıştır. Yaptığımız çalışmaya göre Crp ve Ferritin değerleri erkeklerde daha yüksek, Lenfosit düzeyleri ise kadınlar daha yüksek olduğu saptandı. Ayrıca Crp, Ferritin ve D.Dimer değerleri ile yaş arasında pozitif yönde, Lenfosit ile yaş arasında ise negatif yönde anlamlı bir ilişki saptandı. Biyokimyasal değerlerin hastalığın klinik seyrinde önemli bir biyolojik belirteçler olduğu literatürde ki araştırmalar ile uyumludur. Covid-19 ile ilgili çok sayıda araştırma yapılmış ve literatüre kazandırılmıştır ve yeni çalışmalarda yapılmaktadır. Bizde biyokimyasal değerlerin Covid-19'un klinik seyrinde biyolojik belirteç olarak kullanılması ayrıca bu değerlerin yaş ve cinsiyet üzerindeki ilişkisinin tespitinin hastalığın seyrinde önemli olduğundan bu konu ile ilgili literatüre katkı sağlamayı amaçladık. Hastalığı daha ağır geçiren erkeklerde Crp ve Ferritin değerleri analiz sonuçlarına göre anlamlı yüksek olduğu görüldü. Lenfosit değerinin ise erkeklerde daha düşük olduğu saptandı. Yaşa bağlı olarak ise ileri yaşlarda Crp, Ferritin ve D.Dimer değerlerinin yüksek, Lenfosit değerinin düşük olması mortalite ile bağlantılı olduğunu gösterdi.
Citation - Scopus: 17
Determination of Cytotoxic, Anticholinesterase, Antioxidant and Antimicrobial Activities of Some Wild Mushroom Species
(Informa Healthcare, 2016) Dündar, Abdurrahman; Okumus, V.; Ozdemir, S.; Celik, K.S.; Boğa, M.; Ozcagli, E.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
In the performed study of methanol extraction of wild edible mushroom species; Agaricus arvensis, Agaricus campestris, Armillaria mellea, Fomes fomentarius, Coprinus micaceus, Coriolus versicolor and Lactarius deliciosus were examined for screening their cytotoxic, anticholinesterase, antioxidant and antimicrobial capacity. Phenolic acid composition of mushrooms was also analysed. L. deliciosus and F. fomentarius were generally showed the highest activities at antioxidant test systems (metal chelating, superoxide anion radical scavenging, total antioxidant, 2,2-diphenyl-1-picrylhydrazyl radical scavenging and reducing power activity tests). The highest activities at antimicrobial activity displayed by A. arvensis and as 18 ± 0.8 against to Staphylococcus aureus. The best IC50 values of mushroom methanol extracts at anticancer activities on HeLa and NRK-52E were 7.09 and 18.23 mg/mL exhibited by C. micaceus and A. campestris, respectively. The highest butyrylcholinesterase activity exhibited by L. deliciosus. Total amount of phenolic acids were found as 1,224.70 mg/kg at L. deliciosus. © 2016 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.
Determination of fatty acid compositions of total lipid, phospholipid and triacylglycerol fractions of the wild edible mushroom Pleurotus ostreatus and Russula delica with cytotoxic activities on pc-3 cell lines
(2018) Acay, Hilal; Kaçar, Semra; Keskin, Cumali; Dündar, Abdurrahman; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Fatty acids (FAs) of Pleurotus ostreatus and Russula delica were identified in TL (Total Lipid), TG (Triacylglycerol ) and PL (phospholipid) fractions. The major FAs of TL, TG, PL in both species were Cl6:0 (palmitic açid, PA), Cl8:1 n-9 (oleic acid, OLA) and Cl8:2 n-6 (linoleic acid, LA). In both species, total PUFA amounts were found to be higher than total MUFA and total SFA in TL, TG and PL fractions. The efficient production of the fatty acids especially linolenic and oleic acids which are majorly needed in building blocks of dietary human has confirmed these species as good source of nutrition. On the other hand, insufficiently studied cytotoxic activity (using pC-3 cell lines) of these mushrooms were investigated by using various solvent systems Ethyl acetate extract of Russula delica and, Pleurltus ostreatus showed significant inhibitory value at the concentrations of 520-530 µg/ml (99,45%- 92,82%) against PC-3 cell lines with IC50; 274,53-297,77 µg /mL respectively. Methanol extracts did not show any cytotoxic activity. lt has been found that the potential of cytotoxic activity is depended on concentration and solvent type of extracts. As a result, the present study is a guide for biochemiçal and nutritional values of the both species and can be useful for further investigation on plıarnıacological applications.
Citation - WoS: 4
Citation - Scopus: 3
Different peripheral substituted phthalocyanines: Synthesis, characterization, aggregation behavior, antioxidant and antibacterial activity
(PLEIADES PUBLISHING INC, 2015) Dündar, Abdurrahman; Agirtas, M. S.; Dundar, A.; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
In this study, a novel phthalonitrile, 4-chloro-5-(2-((2-hydroxyethyl)(p-tolyl)amino)ethoxy)phthalonitrile (3), and its metallophthalocyanine derivatives (4-6) are prepared by cyclotetramerization with appropriate metal salts in dimethylformamide. The newly prepared compounds have been characterized by several spectroscopic techniques. All compounds are evaluated for their antioxidant and antibacterial potential. For the antioxidant studies, three tests are applied; DPPH (2,2-diphenyl-1-picrylhydrazylradical) scavenging, metal chelating and reducing power activity. Compound 4 exhibits the best DPPH scavenging activity as 35.2% at 100 mg/L concentration. The metal chelating activities of compounds 3 and 4 are 69.7% and 56.4%, respectively. Reducing power activities of compounds 3 and 4 are higher than alpha-tocopherol which is used as positive control. All compounds show moderate antibacterial activity when compared to the standard antibiotics, amikacin and tetracycline.
Citation - WoS: 0
Citation - Scopus: 0
Effect of pleurotus Ostreatus Water Extract Consumption on Blood Parameters and Cytokine Values in Healthy Volunteers
(Routledge Journals, Taylor & Francis Ltd, 2024) Acay, Hilal; Dündar, Abdurrahman; Arslan, Nurgul; Acay, Hilal; Arslan, Nurgül; Hatipoğlu, Abdulkerim; Yaprak, Bulent; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Objective: Our aim in this study is, does 29-day regular consumption of Pleurotus ostreatus water extract by volunteer individuals who meet the study criteria have an effect on blood and cytokine values? Method: In accordance with the purpose of the study, volunteers were asked to consume 100 ml of the extract every morning for 29 days. Three tubes of blood samples were taken from the volunteers on the 15th and 29th days of the study. Biochemical and hematological analysis of the blood samples were performed and immunomodulatory effects through cytokines were examined. The values obtained from 3 tubes of blood obtained from volunteers before the use of mushroom extract were used as control. The chemical composition and beta-glucan content of 100 ml of mushroom water extract were also analyzed. Result: IL-4, IL-6, IL-10 and IL-13 could not be detected because the values were below the lowest standard value. TNF-alpha, IFN-gamma and IL-1 beta 15th and 29th day values decreased compared to the 1st day (control) values (p < 0.05). However, there was no significant difference observed between the 15th and 29th day. No abnormalities were observed in biochemical and hematological values. Also, the beta-glucan content of extract was found 38.12 mg/100 ml. Conclusion: The frequency range of kidney and liver function test results confirmed that P. osreatus is a reliable food source. Considering the cytokine values these results indicate that P. ostreatus water extract has an anti-inflammatory effect. As no significant difference was observed in 29 days of use, it is thought that 15 days of daily consumption of the extract may be sufficient for the anti-inflammatory effect to occur. However, a large number of qualified clinical trials are needed to support the issue.
Citation - WoS: 1
Investigation of Nutritional Content, Antioxidant Anticancer and Antimicrobial Activities of Pleurotus eryngii (DC. Ex Fr.) Quel, Extract Obtained by Different Solvents
(KSÜ Tarım ve Doğa Dergisi, 2021) Acay, Hilal; Dündar, Abdurrahman; Kaçar, Semra; Keskin, Cumali; Baran, Mehmet Fırat; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The present study related the nutritional contents, fatty acidcompositions, in vitro antioxidant, anticancer and antimicrobialactivities of different solvents extracts of Pleurotus eryngii. Thenutritional contents of the P. eryngii were investigated in detail.Crude protein (g 100 kg-1), carbohydrate (g 100 kg-1), lipid (g 100 kg1), ash (g 100 kg-1), dietary fiber (g 100 kg-1) and energy value (cal100 g-1) of fruiting bodies were analysed. Fatty acid compositions oftotal lipid, phospholipid and triacylglycerol fractions of Pleurotuseryngii were investigated by Gas chromatography. Totally 13 differentfatty acids constituents were identified. Antioxidant propertiesincluding total antioxidant activity, free radical scavenging activity,reducing power activity, metal chelating activity, and superoxideanion radical scavenging activity were evaluated using different tests.The highest total antioxidant, DPPH scavenging, metal chelating, andsuperoxide anion radical scavenging activities were determined inethyl acetate extracts. The potential of cytotoxic activity on PC-3(prostate cancer) cell lines was found to depend on the concentrationand the type of the tested extracts fractions. It was determined thathexane, ethyl acetate, and methanol extracts of Pleurotus eryngii haveinhibition effect on the growth of tested microorganisms. The presentresults suggested that used as a daily nutrient, the Pleurotus eryngiicould be a novel source for new drug developments and promising insome cancer treatment.
Citation - WoS: 26
Citation - Scopus: 33
Metallo and metal free phthalocyanines bearing (4-(1(4-phenoxyphenyl)-1-phenylethyl)phenol substituents: Synthesis, characterization, aggregation behavior, electronic, antioxidant and antibacterial properties
(ELSEVIER SCIENCE SA, 2014) Dündar, Abdurrahman; Guven, M. Emin; Gumus, Selcuk; Ozdemir, Sadin; Dundar, Abdurrahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
As starting material the phthalonitrile derivative bearing (4-(1(4-phenoxyphenyl)-1-phenylethyl)phenol substituents at peripheral position was prepared by a nucleophilic displacement reaction. Cyclotetramerization of 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalonitrile derivative in the presence of corresponding metal salts gave the new metallophthalocyanines. Metal free phthalocyanine was obtained from the reaction of 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalonitrile units. The novel compounds have been characterized by using various spectroscopic data. The aggregation investigations carried out in different concentrations indicate that 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10(-4)-10(-5) M in tetrahydrofuran. The antioxidant activities of novel compounds were analyzed through radical scavenging ability of 1,1-dipheny1-2-picrylhydrazyl, chelating ability to ferrous ions and reducing power. In addition to these, the antibacterial activities of compounds were investigated. Moreover, the ground-state geometries of the complexes were optimized using B3LYP/6-31G(d,p) level of density functional theory in order to predict the three-dimensional geometries and electronic structure. (C) 2014 Elsevier B.V. All rights reserved.
Citation - WoS: 6
Citation - Scopus: 5
Metallo Phthalocyanines bearing 2-Isopropyl-6-methylpyrimidin-4-yloxy Substituents: Synthesis, Characterization, Aggregation Behavior, Antioxidant and Antibacterial Activity, and Electronic Properties
(WILEY-V C H VERLAG GMBH, 2014) Dündar, Abdurrahman; Dede, Emrah; Gumus, Selcuk; Dundar, Abdurrahman; Okumus, Veysi; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
A novel phthalonitrile derivative bearing 2-isopropyl-6-methylpyrimidin-4-yloxy substituents at peripheral positions was synthesized by a nucleophilic substitution reaction. Metallophthalocyanines were obtained from the reaction of the novel phthalonitrile with metal Zn, Cu, Co, and Ni salts. The characterization of the compounds was performed using elemental analysis as well as UV/Vis, FT-IR, and H-1-NMR spectroscopy. The aggregation behaviors of phthalocyanine complexes were also investigated. These metallophthalocyanines do not show any aggregation behavior between 10 (4)-10 (6) M concentration range in THF. The antioxidant activities of the synthesized compounds were evaluated using three different tests: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, metal chelating activity, and reducing power assays. All the compounds exhibited various antioxidant activities. In addition, antimicrobial activity of the compounds was tested over four gram positive and two gram negative bacteria. Moreover, the ground-state geometries of the complexes were optimized using density functional theory (DFT) methods at B3LYP/6-31G(d,p) level in order to obtain information about the 3D arrangements and electronic structure.
Citation - WoS: 29
Citation - Scopus: 36
Mononuclear Complexes Based on Pyrimidine Ring Azo Schiff-Base Ligand: Synthesis, Characterization, Antioxidant, Antibacterial, and Thermal Investigations
(WILEY-V C H VERLAG GMBH, 2014) Dündar, Abdurrahman; Ozdemir, Sadin; Dundar, Abdurrahman; Ispir, Esin; Kurtoglu, Mukerrem; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Six transition metal(II) complexes with the heterocyclic ligand HL (1), [CuL2]center dot H2O (2), [NiL2]center dot 3H(2)O (3), [CoL2]center dot 3H(2)O (4), [MnL2]center dot 3H(2)O (5), [ZnL2]center dot 2H(2)O (6), [PdLOAc]center dot H2O (7) [HL = 5-benzoyl-1-((E)-(2-hydroxy-5-((E)-phenyldiazenyl)benzylidene)amino)-4-phenylpyrimidin-2(1H)-one] were synthesized. The features of the azo Schiff bases were assigned from microanalytical, spectroscopic (IR, UV/Vis., H-1- and C-13 NMR, API-ES mass), magnetic, and molar conductivity measurements at room temperature as well as thermal analysis. The electronic absorption spectroscopy and magnetic susceptibility measurements of the complexes indicate square pyramidal arrangement for Pd-II and octahedral environment for all the other complexes. The azo Schiff base HL acts as a monobasic tridentate ligand, which commonly coordinates through the oxygen atoms of the phenol OH and the pyrimidine one group, and the nitrogen atom of the azomethine group. The thermal behaviors of the ligand and its metal complexes were studied using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The metal complexes proved to be more thermally stable than the ligand; they decomposed at 10-30 degrees C higher temperatures. Antioxidant properties of the ligand and its metal complexes (DPPH free radical scavenging, ferrous chelating and reducing power activities) were tested. Antimicrobial activities were studied with gram-positive bacteria, which included Bacillus subtilis and Staphylococcus aureus, whereas Escherichia coli and Pseudomonas aeruginosa represented gram negative bacteria.
Pleurotus Ostreatus Su Ekstresi Tüketiminin Kan Parametreleri ve Sitokin Değerleri Üzerine Etkisi
(2024) Dündar, Abdurrahman; Dündar, Abdurrahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Fonksiyonel gıdalardan biri olan mantarların protein, yağ ve karbonhidrat gibi temel besinsel ihtiyaçlarımızı karşılarken öte yandan sağlığımız ve özelde immün sistemimiz üzerinde olumlu etkilerinin olduğu hipotezi araştırmaya değer bir konudur. Mantarların immünomodülatör etkileri çoğunlukla in- vitro ve in- vivo (deney hayvanlarında ve hasta bireylerde) olarak çalışılmış olmasına rağmen, özellikle ülkemizde ve dünyada gönüllü sağlıklı bireyler üzerinde yapılan çalışmalar birkaç adetle sınırlı olup, kapsamları da çok dardır. Bu nedenle yapılan çalışmada P. ostraetus'un su ekstraktları sağlıklı gönüllüler tarafından tüketildi. Mantar ekstraktının tüketimi öncesi ve sırasında gönüllülerden alınan kan örneklerinin biyokimyasal ve hematolojik analizleri ve sitokinler aracılığıyla immünomodülatör etkileri analiz edildi. Çalışmadan elde edilen bulgular incelendğinde IL-4, IL-6, IL-10 ve IL-13 değerleri en düşük standart değerin altında olduğundan tespit edilemediği görülmektedir.TNF-α, IFN-γ ve IL-1β 15. ve 29. gün değerleri 1. gün (kontrol) değerlerine göre azaldı (P< 0.05).Ancak 15. ve 29. gün arasında anlamlı bir fark gözlenmedi. Sonuç olarak biyokimyasal ve hematolojik değerlerde herhangi bir anormallik gözlenmedi ve böbrek ve karaciğer fonksiyon testi sonuçlarının sıklık aralığı P. osreatus'un güvenilir bir besin kaynağı olduğunu doğruladı. Sitokin değerleri dikkate alındığında bu sonuçlar, P. ostreatus su ekstraktının antiinflamatuar etkiye sahip olduğunu ve bu etki için 15 günlük tüketimin yeterli olacağını göstermektedir.
Citation - WoS: 58
Citation - Scopus: 60
Preconcentration of metal ions using microbacteria
(SPRINGER WIEN, 2013) Dündar, Abdurrahman; Okumus, Veysi; Kılınç, Ersin; Kilinc, Ersin; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
This review (160 refs). covers the current state of the art of microbacteria-based sorbents for preconcentration of metal ions at trace levels. We highlight advantages and major challenges of the techniques and discuss future perspectives of both batch and column-based methods. Particular attention is paid to the preconcentration of metal ions using resin-immobilized microbacteria for solid phase extractions. We also discuss detection methods including UV-vis spectrophotometry, FAAS, ICP-OES and ICP-MS. Analytical figures of merit are compared, and examples are given for the application to a variety of samples including food, beverages, alloys, water, soil, and geological samples.