WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

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Abu Ubayd’s Understanding Of Naskh;
(Hitit University, 2022) Yaşar, M.A.; Nas, T.
In the period when Islamic sciences were formed, a large number of scholars with absolute ijtihad capacity were trained. One of the scholars mentioned is Abu ‘Ubayd al-Qāsim ibn Sallām al-Khurāsānī al-Harawī who was educated by many famous scholars of the period, had a great influence on both the scientific and political circles. For this reason, he could not be shared by different sect biographers. As a matter of fact, some Shafi’i tabaqat writers counted Ebû Ubeyd as a follower of Imam Shafii. On the other hand, some Hanbali scholars have mentioned Ebû Ubeyd among the class of Hanbali scholars. However, it was concluded that it would be more correct to see Ebû Ubeyd as an independent mujtahid rather than a follower of any madhhab. For, in his own works, the fact that he refers more to Imam Malik rather than Imam Shafii and Ahmad ibn Hanbal and sometimes refers to the views of Abu Hanifa and Imamey indicates this. Ebû Ubeyd, who came to the forefront with his faqih and muhaddis aspects, had a deep knowledge of the subject of naskh, which has a close relationship with these two sciences, and in this regard, he wrote a rare work called en-Nâsiḫ ve’l-mensûḫ fi’l-Ḳurʾâni’lʿazîz ve mâ fîhi mine’l-ferâʾiż ve’s-sünen. While revealing Ebû Ubeyd’s understanding of naskh, his work en-Nâsiḫ ve’l-mensûḫ was used as the main source. In addition to this, his other works related to the subject, especially his work called Kitâbu’l-emvâl, were among the first hand sources that were consulted. It has been tried to determine his approach to naskh based on the statements he made on the subject and the examples he gave in this regard. In this context, Ebû Ubeyd’s approach to the nature and framework of naskh and his views on the evidences that can abrogate each other are examined in this study. Ebû Ubeyd discussed the abrogation in a broader sense as “the modification of a shar’i ruling by a later evidence”, not the established meaning in the methodology as “removal of a shar’i ruling with a later shar’i proof”. In this context, naskh is also used for the allocation of public, the denial of the absolute, the statement of conciseness, the correction of a wrong understanding and the exception made from a general rule. This is known as the understanding of naskh among the companions, tābi‘īn and early convert scholars. However, although Ebû Ubeyd is at the same age as Imam Shafii and has copied and benefited from his works, it is noteworthy that he preferred the predecessor’s approach to the subject rather than the naskh understanding he adopted. It is important to investigate this. He adopted the approach of the public regarding the Shari’a evidences of Ebû Ubeyd that could naskh each other. According to him, the verses of the Qur’an can naskh each other. He gave many examples of this. Another point that draws attention here is to ascribe the concept of naskh used for the verse of the Qur’an by Ebû Ubeyd, from the Lawh-i Mahfuz, in the form of a verse whose recitation is lasting and its meaning is naskhed, and a verse that is removed from people’s hearts by canceling both its recitation and used in different meanings. Ebû Ubeyd stated that sunnah can be naskhed with sunnah, without making any distinction between ahad and mutawatir about sunnah and its naskh. However, despite giving many examples of the naskh of the âhâd sunnah with its own like, no example has been encountered of the naskh of the âhâd sunnah with its own like or with âhâd and the âhâd sunnah with the mutawatir sunnah. As it can be understood from my statements on the subject, Ebû Ubeyd saw that it is permissible to naskh both mutawatir and ahad sunnah with the Qur’an. However, while there is an example for the naskh of the ahad sunnah with the Qur’an in his related works, there is no example for the other. Although there is no clear statement on the issue that the Qur’an can be naskhed with the sunnah, it is understood from some examples that he gives permission for this. © Published by Hitit Ü niversitesi İlahiyat Fakültesi – Hitit University Divinity Faculty, Çorum, Turkey. All rights reserved.
Ahmed Anzavur: Soldier, Governor, and Rebel. a Reevaluation of a Late Ottoman Military Man
(Oriental inst Czech Acad Sci, 2023) Yelbasi, Caner
Following the Russian conquest of the North Caucasus, many Muslims from the region were exiled to the Ottoman Empire from the 1860s onwards. They were settled in different parts of the empire from the Balkans to Anatolia to the Syria and Iraq vilayets. By following this policy, the Ottoman state ensured that many Circassians would become part of the Ottoman army, ruling elites, harems and agricultural workforce. Anzavur Ahmed's family was one of them. Although he did not graduate from military school, he participated in the army during the war in Libya (1911), the Balkan Wars (1912-1913), and the First World War (1914-1918). He was also appointed as the governor of Izmit (1920). Anzavur Ahmet is portrayed as a rebel by Turkish official historiography, but in reality, he was much more than that. He was an Ottoman Governor, and supported by Ottoman administrators such as Damad Ferid and Ali Kemal, who were against the Kuvayi Milliye because they believed that the empire would eventually emerge from the chaotic atmosphere of the post-First World War period and make an agreement with the British. This article argues that although Ahmed Anzavur has been labeled a rebel and a traitor according to the official historiography, it is difficult to use these labels given the circumstances of his time.
Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-Induced Toxicity and Teratogenicity in Xenopus Embryos: an Experimental Study
(Middle Pomeranian Sci Soc Env Prot, 2023) Pekmezekmek, Ayper Boga; Tunç, Erdal; Emre, Mustafa; Tunc, Erdal; Sertdemir, Yasar
It is well documented that nicotine causes low birth weight, preterm birth, pregnancy difficulties, lower fertility, inhibition of spermatogenesis, and decreased steroidogenesis and potassium channels conductance of Xenopus oocytes. Lung cancer is the most well-known adverse impact of nicotine. This work used a 96-hour FETAX test to examine how concurrent administration of glucose monohydrate modifies the effects of exposure to nicotine, nicotine sulfate, and/or glucose on ion channels and membrane potential in Xenopus leavis embryos at an early stage of development. In-vitro fertilised embryos were treated with nicotine and glucose alone or in combination for this aim, and the effects of those treatments were then assessed for potential teratogenic effects. At the conclusion of the FETAX technique, the ratios of healthy, abnormal, and dead embryos were calculated, and the length of embryos in each treatment group was assessed. The ratios of abnormal and dead embryos were considerably higher with nicotine treatment alone compared to controls. Compared to the results of the nicotine-alone treatment group, the ratio of aberrant embryos was marginally reduced by concurrent glucose and nicotine therapy. In contrast, the ratio of normal embryos was raised. Additionally, treatments with glucose, nicotine, and Nic+Glu significantly altered the resting membrane potentials of fertilised oocytes (p < 0.001). Our findings indicated that the simultaneous treatment groups that also received glucose had a protective impact on embryos. Such structured, more sophisticated research is required to confirm these findings.
Amino Acid Profile, Nutrients Content and Yield of Chickpea (Cicer Arietinum L.) Genotypes
(Scibulcom Ltd, 2015) Dogan, Y.; Doğan, Yusuf
Chickpea has significant amounts of all the essential amino acids except sulphur-containing types. It was found that chickpea is a rich source of protein and minerals. The experiments were conducted in a Randomised Complete Block Design with three replications 2013 and 2014 years in South-Eastern Turkey. A total of fifteen varieties, lines and populations were used as materials. In the study were investigated different parameters such as amino acids of protein, seed yield, protein and fat rate in seed, phosphorus, potassium, calcium, manganese, zinc, copper and iron contents and of seeds. The essential amino acid leucine (8.43 mg/100 g in 2013 and 8.59 mg/100 g in 2014) was found in highest concentration, followed by lysine (7.14 mg/100 g in 2013 and 7.27 mg/100 g in 2014) and phenylalanine (5.99 mg/100 g in 2013 and 6.07 mg/100 g in 2014) in the chickpea. Mineral composition of chickpea genotypes showed that they contribute sufficient amount of Ca, P, K, Cu, Zn and Mg in human diets to meet the recommended dietary allowance. According to the average of two years, the highest grain yield was obtained from Diyar-95 variety with 1618 kg ha(-1), the lowest grain yield was obtained from M-1 local population with 1104 kg ha(-1).
An Examination of the Effects of Propolis and Quercetin in a Rat Model of Streptozotocin-Induced Diabetic Peripheral Neuropathy
(Mdpi, 2024) Şeker, Uğur; Celik, Hakim; Dagli, Seyda Nur; Taskin, Seyhan; Seker, Ugur; Deniz, Mustafa
The purpose of this study was to reveal the combined effects of propolis (P) and quercetin (Q) against diabetic peripheral neuropathy developing with streptozotocin-induced diabetes in rats. Sixty-four adult male rats were divided into eight equal groups: control, P (100 mg/kg/day), Q (100 mg/kg/day), P + Q (100 mg/day for both), diabetes mellitus (DM) (single-dose 60 mg/kg streptozotocin), DM + P, DM + Q, and DM + P + Q. The rats were sacrificed, and blood and sciatic nerve tissues were collected. Blood glucose and malondialdehyde (MDA) levels increased, while IL-6 and total antioxidant status decreased in the DM group (p = 0.016 and p = 0.047, respectively). Ultrastructural findings showed degeneration of the axon and myelin sheath. The apoptotic index (AI %), TNF-alpha, and IL-1 beta immunopositivity increased significantly in the DM group (p < 0.001). Morphological structures approaching those of the controls were observed in the DM + P, DM + Q, and DM + P + Q groups. Morphometric measurements increased markedly in all treatment groups (p < 0.001), while blood glucose and MDA levels, AI (%), TNF-alpha, and IL-1 beta immunopositivity decreased. In conclusion, the combined effects of propolis and quercetin in diabetic neuropathy may provide optimal morphological protection with neuroprotective effects by reducing hyperglycemia, and these may represent a key alternative supplement in regenerative medicine.
Anatolian Livestock Trade in the Late Ottoman Empire
(Routledge Journals, Taylor & Francis Ltd, 2025) Ciftci, Erdal
Antioxidant, Ache Inhibitory, and Anticancer Effects of Verbascum Thapsus Extract
(C M B Assoc, 2023) Keskin, Cumali; Baran, Ayşe; Valioglu, Ferzane; Teng, Lei; Atalar, Mehmet Nuri; Keskin, Cumali; Beilerli, Aferin
Verbascum thapsus (Mullein) is a medicinal plant used in folk medicine to treat various ailments. For this study, the biological functions of Verbascum thapsus (VT) methanol extract were determined in vitro. The plant's methanol extract was created through the maceration process. The phytochemical composition of plant extracts was investigated using liquid chromatography-electrospray ionization tandem mass spectrometry. The antioxidant capacity of the extract was determined using the 2,2-diphenyl-1-picrylhydrazil (DPPH radical) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS radical). Cell lines Caco-2 (human colorectal adenocarcinoma cells), LNCaP (Lymph Node Carcinoma of Prostate), and HEK293 (Human embryonic kidney 293 cells) were used to model colon, prostate, and non-cancerous cells. The cytotoxic activity of the plant extract on the proliferation of these cells was determined by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) assay protocol. VT extract showed moderate DPPH and ABTS radical scavenging activities at 30 mg/ml concentration. With this, VT extract was determined to inhibit acetylcholinesterase (AChE) enzyme and had strong cytotoxic activity on cancerous cell lines. In addition, our findings clearly showed that the plant extract had greater cytotoxic activity on the viability of cancerous cells compared to non-cancerous (Human embryonic kidney cells; HEK293) cells. The current findings showed that V. thapsus might be a promising anti-cancer medication candidate for the treatment of human colorectal adenocarcinoma and colon cancer, as well as a good source antioxidans. Copyright: (c) 2023 by the C.M.B. Association. All rights reserved.
Application of Ammi Model for Evaulation Spring Barley Genotypes in Multi-Environment Trials
(Bangladesh Botanical Soc, 2016) Kendal, Enver; Tekdal, Sertac
The aim of study was to evaluate the yield performance of genotypes and stability, environments and G x E interaction of 12 spring barley genotypes in multi-environment trials. The trials were implemented in respect to a integrate arrangement complex style with four replications. The AMMI (Additive main effects and multiplicative interaction) analysis was made to estimate grain yield and understand G x E interaction patterns. Analysis indicated that the major contributions to treatment sum of squares were environments (81.4%), GE (10.3%) and genotypes (8.3%), respectively; suggesting that grain yield of genotypes was effected environmental conditions. PCA 1 and PCA 2 axes (Principal component) were significant (0.01) and supplied to 68.30% of the complete G x E interaction. The AMMI analysis revealed that E3 and E5 were more stable and high productive; mean while E6 and E7 were unstable and nominal efficient environments. According to stability variance, the genotypes (G1, G3, G6 and G9) were the productive and more stable; meanwhile G4 and G5 were low productive and stable genotypes. Moreover, G2 were the best productive to all environments without E2. The G x E model exposed according to AMMI analysis recommended that G2 shown candidates and registered as Kendal, because of wide adaptability with high performances in all environments.
Architecture After Crisis a Journey Through Contemporary Commoning Practices
(Pontificia Univ Catolica Chile, Escuela Arquitectura, 2015) Tan, Pelin
After the economic crisis of 2008 many architects have devoted to the search of an alternative and communal production model capable of exploring diverse parallel platforms without having to cave in to the pressures of a capitalist economy. This text presents a journey through several contemporary examples, analyzing the possibilities that arise when commonality replaces professionalization in architecture.
Architecture in Crisis Exception as a Form of Decay
(Pontificia Univ Catolica Chile, Escuela Arquitectura, 2016) Tan, Pelin
Although Agamben defines the camp (concentration or refugees camp) as the paradigm of the state of exception, this statement overlooks not only the physical and spatial conditions of the camp, but also everyday practices that take place inside. Analyzing the spatial practices in current refugee camps in Turkey, the text shows that its design often forgets the very humanity of the refugee.
Armillaria Species Causing Kiwifruit Vine Decline and Root Rot in Northeastern Türkiye: a Growing Concern for Kiwifruit Health
(Wiley, 2024) Derviş, Sibel; Bozoglu, Tugba; Dervis, Sibel; Erper, Ismail; Ozer, Goksel
Kiwifruit (Actinidia deliciosa) production in northeastern T & uuml;rkiye is facing an emerging threat from Armillaria root rot. Surveys conducted in August 2021 and 2022 revealed that 10.5%-17.5% of the 200-500 vines within each of 35 kiwifruit orchards in the Per & scedil;embe, G & uuml;lyal & imath; and Alt & imath;nordu districts of Ordu province exhibited symptoms of Armillaria root rot, including complete defoliation. Diseased plants exhibited diagnostic signs on their root collars and woody roots, including white mycelial fans, extensive wood rot and rhizomorphs. A single Armillaria isolate was obtained from each of the 35 symptomatic orchards. Molecular identification, employing DNA sequencing of the large subunit (LSU) region of rDNA, the translation elongation factor subunit 1-alpha (TEF1) gene and the second largest RNA polymerase II B-subunit (RPB2) gene, identified 20 isolates as Armillaria gallica and 15 as A. mellea. Phylogenetic analyses, based on TEF1 alignments, further supported the species identification with a 100% bootstrap value. To examine genetic diversity, start codon targeted (SCoT) marker 13 was used, successfully differentiating the two Armillaria species and revealing three distinct clades. Clades I and II comprised 15 and 5 isolates of A. gallica, respectively, while Clade III contained all 15 A. mellea isolates. Pathogenicity testing on kiwifruit seedlings (cv. Hayward) revealed the ability of both A. gallica and A. mellea isolates to induce disease. Rhizomorph-producing isolates in kiwifruit seedlings displayed high virulence, inducing severe leaf necrosis and seedling mortality, while isolates lacking these structures were non-pathogenic. This study identifies the first global instance of A. gallica causing kiwifruit root rot. This finding, along with the identification of A. mellea as a causal agent in the country, highlights the emerging threat of Armillaria root rot to kiwifruit production in the region.
Armillaria Species Causing Kiwifruit Vine Decline and Root Rot in Northeastern Turkiye: a Growing Concern for Kiwifruit Health (Vol 172, E13409, 2024)
(Wiley, 2025) Derviş, Sibel; Bozoglu, Tugba; Dervis, Sibel; Erper, Ismail; Ozer, Goksel
Assessment of Correlative Digital Drawing Features in the Design Processes of Unstructured Creativity
(Ecaade-education & Research Computer Aided Architectural design Europe, 2023) Aydin, Serdar; Aydın, Serdar; Sik, Busra; Yoruk, Merve Sule; Aktas, Begum
This research critically challenges the conventional perception of drawings as mere technical blueprints and delves into the intricate integration of design ideation, abstraction, and speculation with geometrical manipulations and semantic labelling. By focusing on unconventional architectural design studio experiments at the undergraduate level, the study aims to explore the role of creativity in speculative drawing. It adopts a 3-dimensional design thinking process that transcends the rigid constraints of traditional drawings and embraces the fluidity of representational norms. Furthermore, the paper elucidates on the pedagogical aspects of the design studio, including the unstructured creativity inherent in the design process. The methodology employed in this study is exemplified through different stages of the design studio, incorporating a variety of representations such as 2D, 2.5D, and 3D, encompassing scalar, geometric, and material transfigurations. To assess the outcomes of the studio, the research utilises correlation diagrams that establish connections between digital drawing features at different stages and the unstructured creativity manifested in the final design. These scatter and correlation diagrams capture the syntactic relationships between the objects within digital drawings. The findings of this study reveal insight on the nuanced interplay between intuitive, reflective, and retrospective aspects of unstructured creativity during the design ideation process. By unravelling the intricate role of digital design tools and methods this research contributes to a deeper understanding of how design ideation is generated and manifested through the dynamic interplay of the modulating compounds of drawing objects. It highlights the significance of meaningful, conceptual, and speculative representations that directly relate to the creation of buildable forms and architectural spaces. Through its critical insights, this study paves the way for advancements in the field of CAAD and offers valuable perspective for architectural education and practice.
Bedouin Bureaucrats: Mobility and Property in the Ottoman Empire.
(Burhan Caglar, 2024) Ciftci, Erdal
This monograph examines the imperial nation-building process in the latter half of the nineteenth century, centering on tent-dwelling Bedouin tribes of inner Syria, predominantly in the Transjordan region. Investigating interactions among Bedouin chiefs, commercial-capitalists, urban elites, and Ottoman officials from the eighteenth to the early twentieth century, it illustrates the central role of Bedouin bureaucrats in fostering mutually beneficial relationships within or outside the state sphere.
Characterization of Durum Wheat (triticum durum L.) Landraces Regarding To Some Agronomic Traits
(Univ Namik Kemal, 2023) Aktaş, Hüsnü; Aktas, Husnu
This research was conducted in 2019-20 wheat growing season under rainfall condition of Mardin - Artuklu province. 80 durum wheat landraces originated from Southeast Anatolia and 10 registered durum wheat cultivars were evaluated according to Augmented Trail Design. 20 landraces and 10 cultivars were used for each bloc. We determined large variations in durum wheat landraces for observed traits. Results indicated that mean of observed traits of landraces and varieties were ranged between 229 kg/da - 371 kg/da for grain yield; 1313 kg/kg - 1218 kg/kg for biomass, 18.02 % - 14.94 % for grain protein content. Mean thousand kernel weight of landraces and standard varieties changed between 42.9 g and 40.15 g; heading days ranged from 117.8 to 111 days respectively. According to observed data, landraces had longer heading days and grain stage and also higher grain protein content and biomass compare to standard varieties. Results of this study showed that landraces has high potential to increase biomass and grain protein content and they can be used as a genitor in wheat breeding programs to improving desirable durum wheat genotypes. Observation according to GGE biplot methodology (which-wonwhere) indicated that ST8 (Check) and G80 (landrace) have high values for grain yield, number of seed pers spike, seed weight per spike while G8 (landrace) showed high values for thousand grain weight, length of peduncle, plant height, grain protein content, biomass and heading days. Obtained results from this study indicated that landraces should be preserved for sustainable agriculture activities specially for marginal areas, also they have high diversity and useful traits for national and international wheat breeding programs.
The Church of Virgin at Amida and the Martyrium at Constantia: Two Monumental Centralised Churches in Late Antique Northern Mesopotamia
(Mersin University, 2013) Keser-Kayaalp, E.; Keser Kayaalp, Elif
Late Antique Northern Mesopotamia, which was situated at the eastern edge of the Byzantine Empire, was dotted with important cities such as Edessa (Urfa), Anastasiopolis (Dara), Amida (Diyarbakir), Martryropolis (Silvan), Constantia (Viranşehir) and Nisibis (Nusaybin). These cities were wealthy and highly cosmopolitan. As a result, the region had a sophisticated architecture which was by no means inferior to that found in other parts of the Byzantine Empire. This article deals with two monumental centralised churches in Northern Mesopotamia, namely the Church of the Virgin at Amida and the Octagon at Constantia. It concentrates firstly on the Church of the Virgin, which is an aisled-tetraconch church, a familiar plan type repeated in different parts of the Empire, and secondly on the Octagon at Constantia which has some unique features but shares the ambulatory design, long eastern chamber, use of materials and the monumentality with the aisled-tetraconch at Amida. By contextualising these two churches together, which has not been done in the past, this paper sheds further light on these neglected structures and reconsiders their reconstructions, dating, dedications and possible prototypes.
Comparison of Lipid Contents and Fatty Acid Profiles of Freshwater Fish From the Ataturk Dam Lake
(Walter de Gruyter Gmbh, 2016) Kacar, Semra; Kaçar, Semra; Bashan, Mehmet
Objective: The objective of the study was to examine the lipid levels, fatty acid profiles (especially EPA and DHA which play an important role in the prevention of a wide variety disorders such as; coronary heart disease, hypertension, rheumatoid arthritis, breast and colon cancer, Alzheimer disease, inflammation and autoimmune disorders) and n-3/n-6 ratio of some freshwater fish in Ataturk Dam Lake. Methods: Samples of 12 fish species from the Ataturk Dam Lake (Turkey) were investigated for their fat content and fatty acid composition (Aspius vorax, Carasobarbus luteus, Carassius gibelio, Liza abu, Acanthobrama marmid, Barbus xanthopterus, Cyprinion macrostomum, Carassius auratus, Calcalburnus mossulensis, Capoeta trutta, Mastacembelus simack, Chondrostoma regium). Total lipids were extracted with 10 ml of chloroform-methanol (2/1v/v). Samples containing muscle lipid were transesterified with acidified methanol. The fatty acid methyl esters were extracted with hexane. Fatty acids were detected by gas chromatography (GC). Results: The lipid content of species ranged from 0.78% to 2.51%. The highest lipid content was found in female C. trutta (2.51%). The major SFAs were myristic acid (C14:0), palmitic acid (C16:0) and stearic acid (C18: 0). Oleic acid (C18:1 n-9) and palmitoleic acid (C16:1 n-7) were the prominent MUFA. The dominant PUFAs were linoleic acid (LA, C18:2 n-6), linolenic acid (ALA, C18:3 n-3), arachidonic acid (AA, C20:4 n-6), eicoesapentaenoic acid (EPA, C20: 5 n-3) and docoesahexaenoic acid (DHA, C22:6 n-3). The ratio of n-3/n-6 PUFAs ranged from 1.22 to 4.71. Conclusion: In this study, the fatty acid composition varied between different species In addition, the highest n-3/n-6 ratios were observed in female C. trutta, C. mossulensis, C. regium and A. vorax. Therefore, these species are economically important fish considering n-3 fatty acids and n-3/n-6 ratios.
Different peripheral substituted phthalocyanines: Synthesis, characterization, aggregation behavior, antioxidant and antibacterial activity
(PLEIADES PUBLISHING INC, 2015) Dündar, Abdurrahman; Agirtas, M. S.; Dundar, A.
In this study, a novel phthalonitrile, 4-chloro-5-(2-((2-hydroxyethyl)(p-tolyl)amino)ethoxy)phthalonitrile (3), and its metallophthalocyanine derivatives (4-6) are prepared by cyclotetramerization with appropriate metal salts in dimethylformamide. The newly prepared compounds have been characterized by several spectroscopic techniques. All compounds are evaluated for their antioxidant and antibacterial potential. For the antioxidant studies, three tests are applied; DPPH (2,2-diphenyl-1-picrylhydrazylradical) scavenging, metal chelating and reducing power activity. Compound 4 exhibits the best DPPH scavenging activity as 35.2% at 100 mg/L concentration. The metal chelating activities of compounds 3 and 4 are 69.7% and 56.4%, respectively. Reducing power activities of compounds 3 and 4 are higher than alpha-tocopherol which is used as positive control. All compounds show moderate antibacterial activity when compared to the standard antibiotics, amikacin and tetracycline.
distribution of Oxa-Type Carbapenemase Genes in Carbapenem-resistant Acinetobacter Baumannii strains: an Investigation by Real-Time Polymerase Chain Reaction Method
(Doc design informatics Co Ltd, 2019) Demir, Cemil; Yigin, Akin; Demir, Cemil
Objective: Carbapenems are the most important broad spectrum antimicrobials used in the treatment of Acinetobacter baumannii infections, but resistance to carbapenems is increasing worldwide. In this study, we aimed to investigate the distribution of OXA-type carbapenemase genes observed in carbapenem-resistant A. baumannii strains by real-time polymerase chain reaction (PCR) method and to provide epidemiological data. Methods: Between January 2016 and January 2018, 20 carbapenem-resistant A. baumannii strains from clinical specimens were included in the study. DNA isolations were performed, and distribution of OXA-type carbapenemase genes were examined using primers and TaqMan probes specific to genes of OXA-23, OXA-24, OXA-51 and OXA-58 carbapenemases by real-time PCR method. Results: Tigecycline was the best choice for carbapenem-resistant A. baumannii strains, of which 16 (80%) were susceptible to this antimicrobial. bla(OXA-51) was detected in all strains, while bla(OXA-24) was detected in only 1 (5%) strain. Of 20 strains, 10 showed the presence of bla(OXA-23) and bla(OXA-51) simultaneously. Conclusions: Simultaneous occurence of bla(OXA-23) and bla(OXA-51 )is remarkable in terms of distribution of OXA-type carbapenemases in carbapenem-resistant A. baumannii strains. Valuable epidemiological data can be obtained by performing routine surveillance of such strains by means of techniques that can produce fast and reliable results such as real-time PCR.
Docetaxel-Loaded, Dipeptide-Functionalized Γ-Fe2o3 Magnetic Nanoparticles: Synthesis, Characterization, and Targeting To Prostate Cancer
(John Wiley and Sons Inc, 2025) Gungoren, M.; Koyuncu, I.; Kilinc, E.; Baysal, Z.
A new delivery system was designed and synthesized to increase the efficiency of docetaxel. For this aim, γ-Fe2O3 was synthesized in order to give the nanoparticle the ability to be magnetic targeted. It was functionalized with citric acid to prevent clumping and maintain stability. To increase the interaction efficiency between the delivery system and the drug, leucine–glycine dipeptide and an amphiphilic polymer, Pluronic F127, were attached to the nanoparticle. Characterization studies were carried out with XRD, ICP–MS, vibrating sample magnetometer (VSM), TEM, and zeta potential to elucidate the structure of this carrier system. After docetaxel was bound to the synthesized carrier, its therapeutic effect was measured by spectrophotometric and flow cytometric methods (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide [MTT], reactive oxygen species [ROS], and apoptosis). Docetaxel-bound nanoparticles significantly reduced the viability of the tumor cell compared to the healthy cell in a dose-dependent manner, especially at 24 (50.14 ± 13.25 to 22.32 ± 5.51 at 100 µg/mL) h and 48 (41.46 ± 2.22 to 18.80 ± 2.81 at 100 µg/mL) h. The rate of apoptosis and ROS in the negative sample increased from 2.7% to 15.4% and from 9.6% to 74.7%, respectively, as a result of treatment with 15 µg/mL γ-Fe2O3/C/LG/F127/Dotx. Thus, it can be said that the synthesized carrier system is a suitable candidate for the improvement of docetaxel transport. © 2025 Wiley-VHCA AG, Zurich, Switzerland.

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