WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

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Abu Ubayd’s Understanding Of Naskh;
(Hitit Univ, 2022) Yasar, Mehmet Aziz; Nas, Taha
In the period when Islamic sciences were formed, a large number ofscholars with absolute ijtihad capacity were trained. One of the scholars mentioned is Abu `Ubayd al- Qasim ibn Sallam al-Khurasani al-Harawi who was educated by many famous scholars of the period, had a great influence on both the scientific and political circles. For this reason, he could not be shared by different sect biographers. As a matter of fact, some Shafi'i tabaqat writers counted Ebu Ubeyd as a follower of Imam Shafii. On the other hand, some Hanbali scholars have mentioned Ebu Ubeyd among the class of Hanbali scholars. However, it was concluded that it would be more correct to see Ebu Ubeyd as an independent mujtahid rather than a follower of any madhhab. For, in his own works, the fact that he refers more to Imam Malik rather than Imam Shafii and Ahmad ibn Hanbal and sometimes refers to the views of Abu Hanifa and Imamey indicates this. Ebu Ubeyd, who came to the forefront with his faqih and muhaddis aspects, had a deep knowledge of the subject of naskh, which has a close relationship with these two sciences, and in this regard, he wrote a rare work called en-Nasih ve'l-mensu. fi'l-kur.ani'l-aziz ve ma fihi mine'l-fera'iz ve's-sunen. While revealing Ebu Ubeyd's understanding of naskh, his work en-Nasi. ve'l-mensu. was used as the main source. In addition to this, his other works related to the subject, especially his work called Kitabu'l- emval, were among the first hand sources that were consulted. It has been tried to determine his approach to naskh based on the statements he made on the subject and the examples he gave in this regard. In this context, Ebu Ubeyd's approach to the nature and framework of naskh and his views on the evidences that can abrogate each other are examined in this study. Ebu Ubeyd discussed the abrogation in a broader sense as "the modification of a shar'i ruling by a later evidence", not the established meaning in the methodology as "removal of a shar'i ruling with a later shar'i proof". In this context, naskh is also used for the allocation of public, the denial of the absolute, the statement of conciseness, the correction of a wrong understanding and the exception made from a general rule. This is known as the understanding of naskh among the companions, tabi`in and early convert scholars. However, although Ebu Ubeyd is at the same age as Imam Shafii and has copied and benefited from his works, it is noteworthy that he preferred the predecessor's approach to the subject rather than the naskh understanding he adopted. It is important to investigate this. He adopted the approach of the public regarding the Shari'a evidences of Ebu Ubeyd that could naskh each other. According to him, the verses of the Qur'an can naskh each other. He gave many examples of this. Another point that draws attention here is to ascribe the concept of naskh used for the verse of the Qur'an by Ebu Ubeyd, from the Lawh-i Mahfuz, in the form of a verse whose recitation is lasting and its meaning is naskhed, and a verse that is removed from people's hearts by canceling both its recitation and used in different meanings. Ebu Ubeyd stated that sunnah can be naskhed with sunnah, without making any distinction between ahad and mutawatir about sunnah and its naskh. However, despite giving many examples of the naskh of the ahad sunnah with its own like, no example has been encountered of the naskh of the ahad sunnah with its own like or with ahad and the ahad sunnah with the mutawatir sunnah. As it can be understood from my statements on the subject, Ebu Ubeyd saw that it is permissible to naskh both mutawatir and ahad sunnah with the Qur'an. However, while there is an example for the naskh of the ahad sunnah with the Qur'an in his related works, there is no example for the other. Although there is no clear statement on the issue that the Qur'an can be naskhed with the sunnah, it is understood from some examples that he gives permission for this.
Ahmed Anzavur: Soldier, Governor, and Rebel. a Reevaluation of a Late Ottoman Military Man
(Oriental Inst Czech Acad Sci, 2023) Yelbasi, Caner
Following the Russian conquest of the North Caucasus, many Muslims from the region were exiled to the Ottoman Empire from the 1860s onwards. They were settled in different parts of the empire from the Balkans to Anatolia to the Syria and Iraq vilayets. By following this policy, the Ottoman state ensured that many Circassians would become part of the Ottoman army, ruling elites, harems and agricultural workforce. Anzavur Ahmed's family was one of them. Although he did not graduate from military school, he participated in the army during the war in Libya (1911), the Balkan Wars (1912-1913), and the First World War (1914-1918). He was also appointed as the governor of Izmit (1920). Anzavur Ahmet is portrayed as a rebel by Turkish official historiography, but in reality, he was much more than that. He was an Ottoman Governor, and supported by Ottoman administrators such as Damad Ferid and Ali Kemal, who were against the Kuvayi Milliye because they believed that the empire would eventually emerge from the chaotic atmosphere of the post-First World War period and make an agreement with the British. This article argues that although Ahmed Anzavur has been labeled a rebel and a traitor according to the official historiography, it is difficult to use these labels given the circumstances of his time.
Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-Induced Toxicity and Teratogenicity in Xenopus Embryos: an Experimental Study
(Middle Pomeranian Sci Soc Env Prot, 2023) Emre, Mustafa; Tunc, Erdal; Sertdemir, Yasar; Pekmezekmek, Ayper Boga
It is well documented that nicotine causes low birth weight, preterm birth, pregnancy difficulties, lower fertility, inhibition of spermatogenesis, and decreased steroidogenesis and potassium channels conductance of Xenopus oocytes. Lung cancer is the most well-known adverse impact of nicotine. This work used a 96-hour FETAX test to examine how concurrent administration of glucose monohydrate modifies the effects of exposure to nicotine, nicotine sulfate, and/or glucose on ion channels and membrane potential in Xenopus leavis embryos at an early stage of development. In-vitro fertilised embryos were treated with nicotine and glucose alone or in combination for this aim, and the effects of those treatments were then assessed for potential teratogenic effects. At the conclusion of the FETAX technique, the ratios of healthy, abnormal, and dead embryos were calculated, and the length of embryos in each treatment group was assessed. The ratios of abnormal and dead embryos were considerably higher with nicotine treatment alone compared to controls. Compared to the results of the nicotine-alone treatment group, the ratio of aberrant embryos was marginally reduced by concurrent glucose and nicotine therapy. In contrast, the ratio of normal embryos was raised. Additionally, treatments with glucose, nicotine, and Nic+Glu significantly altered the resting membrane potentials of fertilised oocytes (p < 0.001). Our findings indicated that the simultaneous treatment groups that also received glucose had a protective impact on embryos. Such structured, more sophisticated research is required to confirm these findings.
Citation - WoS: 1
Citation - Scopus: 2
Amino Acid Profile, Nutrients Content and Yield of Chickpea (Cicer Arietinum L.) Genotypes
(Scibulcom Ltd, 2015) Dogan, Y.; Doğan, Yusuf; 06.02. Department of Plant Protection / Bitki Koruma Bölümü; 06. Faculty of Agricultural Sciences and Technologies in Kızıltepe / Kızıltepe Tarım Bilimleri ve Teknolojileri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Chickpea has significant amounts of all the essential amino acids except sulphur-containing types. It was found that chickpea is a rich source of protein and minerals. The experiments were conducted in a Randomised Complete Block Design with three replications 2013 and 2014 years in South-Eastern Turkey. A total of fifteen varieties, lines and populations were used as materials. In the study were investigated different parameters such as amino acids of protein, seed yield, protein and fat rate in seed, phosphorus, potassium, calcium, manganese, zinc, copper and iron contents and of seeds. The essential amino acid leucine (8.43 mg/100 g in 2013 and 8.59 mg/100 g in 2014) was found in highest concentration, followed by lysine (7.14 mg/100 g in 2013 and 7.27 mg/100 g in 2014) and phenylalanine (5.99 mg/100 g in 2013 and 6.07 mg/100 g in 2014) in the chickpea. Mineral composition of chickpea genotypes showed that they contribute sufficient amount of Ca, P, K, Cu, Zn and Mg in human diets to meet the recommended dietary allowance. According to the average of two years, the highest grain yield was obtained from Diyar-95 variety with 1618 kg ha(-1), the lowest grain yield was obtained from M-1 local population with 1104 kg ha(-1).
Anatolian Livestock Trade in the Late Ottoman Empire
(Routledge Journals, Taylor & Francis Ltd, 2025) Ciftci, Erdal; 17.06. Department of Architecture and Urban Planning / Mimarlık ve Şehir Planma Bölümü; 17. Vocational Higher School / Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Antioxidant, Ache Inhibitory, and Anticancer Effects of Verbascum Thapsus Extract
(CMB Assoc, 2023) Zhang, Na; Baran, Ayse; Valioglu, Ferzane; Teng, Lei; Atalar, Mehmet Nuri; Keskin, Cumali; Beilerli, Aferin
Verbascum thapsus (Mullein) is a medicinal plant used in folk medicine to treat various ailments. For this study, the biological functions of Verbascum thapsus (VT) methanol extract were determined in vitro. The plant's methanol extract was created through the maceration process. The phytochemical composition of plant extracts was investigated using liquid chromatography-electrospray ionization tandem mass spectrometry. The antioxidant capacity of the extract was determined using the 2,2-diphenyl-1-picrylhydrazil (DPPH radical) and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS radical). Cell lines Caco-2 (human colorectal adenocarcinoma cells), LNCaP (Lymph Node Carcinoma of Prostate), and HEK293 (Human embryonic kidney 293 cells) were used to model colon, prostate, and non-cancerous cells. The cytotoxic activity of the plant extract on the proliferation of these cells was determined by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) assay protocol. VT extract showed moderate DPPH and ABTS radical scavenging activities at 30 mg/ml concentration. With this, VT extract was determined to inhibit acetylcholinesterase (AChE) enzyme and had strong cytotoxic activity on cancerous cell lines. In addition, our findings clearly showed that the plant extract had greater cytotoxic activity on the viability of cancerous cells compared to non-cancerous (Human embryonic kidney cells; HEK293) cells. The current findings showed that V. thapsus might be a promising anti-cancer medication candidate for the treatment of human colorectal adenocarcinoma and colon cancer, as well as a good source antioxidans. Copyright: (c) 2023 by the C.M.B. Association. All rights reserved.
Citation - WoS: 14
Application of Ammi Model for Evaulation Spring Barley Genotypes in Multi-Environment Trials
(Bangladesh Botanical Soc, 2016) Kendal, Enver; Tekdal, Sertac; 16.02. Department of Seed Production / Tohumculuk Teknolojisi Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The aim of study was to evaluate the yield performance of genotypes and stability, environments and G x E interaction of 12 spring barley genotypes in multi-environment trials. The trials were implemented in respect to a integrate arrangement complex style with four replications. The AMMI (Additive main effects and multiplicative interaction) analysis was made to estimate grain yield and understand G x E interaction patterns. Analysis indicated that the major contributions to treatment sum of squares were environments (81.4%), GE (10.3%) and genotypes (8.3%), respectively; suggesting that grain yield of genotypes was effected environmental conditions. PCA 1 and PCA 2 axes (Principal component) were significant (0.01) and supplied to 68.30% of the complete G x E interaction. The AMMI analysis revealed that E3 and E5 were more stable and high productive; mean while E6 and E7 were unstable and nominal efficient environments. According to stability variance, the genotypes (G1, G3, G6 and G9) were the productive and more stable; meanwhile G4 and G5 were low productive and stable genotypes. Moreover, G2 were the best productive to all environments without E2. The G x E model exposed according to AMMI analysis recommended that G2 shown candidates and registered as Kendal, because of wide adaptability with high performances in all environments.
Arap Edebiyatı Tarihi Yazımının Kuramsal ve Metodolojik Temelleri
(Hitit Univ, 2024) Simsek, Sultan; Araz, Ismail
The writing of literary history as a scientific discipline was initiated by Western researchers in the late 18th century, as a result of a modern research endeavor, distinct from the long-standing tradition of literary works. In the modern era, firstly the literature of the history of nations was written. Arabic literary history also benefited from this process, and it is considered one of the earliest examples of literary historiography. In the second half of the 19th century, the works of writers such as Hammer Purgstall (d. 1856) and Alfred von Kremer (d. 1889) on the history of Arabic literature emerged as pioneering studies. The writing process accelerated with Carl Brockelmann's (d. 1956) comprehensive work, leading to the production of numerous Arabic literary history books in both the West and the East, continuing to the present day. While this process contributed to enriching the literature of literary history, it also sparked various theoretical and methodological debates. Since the 19th century, different approaches have been proposed in the writing of Arabic literary history, and there is no theoretical unity in this regard. This situation, which complicates the understanding and interpretation of literary history works, poses an obstacle to developing literary history writing based on scientific criteria. To benefit greatly from reading literary history books, it is crucial to know the authors' perspectives, approaches to the subject, and methods. Aware of this importance, our article focuses on the theoretical and methodological framework used in studies of Arabic literary history. The article examines the writing theories and methods that are often not clearly and explicitly expressed by the authors in the writing of Arabic literary history. However, philosophical differences between the East and the West in literary historiography, the relationship between literature and history, criteria for determining periods, and the ideal method for writing literary history, which is beyond the scope of the article, are not discussed. The main aim of the article is to provide information about the methods and theories applied in Arabic literary history writing, to raise the awareness of researchers about the background of works in this field, offer a more informed reading perspective, and draw attention to the many aspects of the subject that still await further study. Today, despite the numerous studies on Arabic literary history that focus on specific periods, literary figures, and genres, research on theoretical approaches and methodology is almost nonexistent, leaving a significant gap in the field. Our article can be considered a modest step toward filling this gap. To substantiate the conclusions reached in the article, descriptive methods of qualitative research were employed throughout the study, and the obtained data were evaluated by using analytical methods. In this context, the emergence of Arabic literary history and its transmission to the Eastern world were highlighted to provide a better understanding of the scope of the subject. The article discusses how writing of literature history was applied among Arabic literary historians as a theoretical and methodological problem during this transmission process from the West to the East, based on primary sources. At this point, the methodological foundations and areas of influence in Arabic literary history writing were discussed. Additionally, the most widely adopted literary history method and its implications among the methodological problems were examined. As a result of the evaluations, it was determined that the methods followed in the writing of Arabic literary history were highly diverse and that some methods were synthesized. The article concludes that there is a need for indepth new research to evaluate holistically the accumulated knowledge in this area, given the diverse methods employed by literary historians, the complex and multifaceted nature of the field, and the lack of consensus on a single method.
Citation - WoS: 4
Citation - Scopus: 3
Armillaria Species Causing Kiwifruit Vine Decline and Root Rot in Northeastern Türkiye: a Growing Concern for Kiwifruit Health
(Wiley, 2024) Turkkan, Muharrem; Bozoglu, Tugba; Dervis, Sibel; Erper, Ismail; Ozer, Goksel; 16.01. Department of Organic Agriculture / Organik Tarım Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Kiwifruit (Actinidia deliciosa) production in northeastern T & uuml;rkiye is facing an emerging threat from Armillaria root rot. Surveys conducted in August 2021 and 2022 revealed that 10.5%-17.5% of the 200-500 vines within each of 35 kiwifruit orchards in the Per & scedil;embe, G & uuml;lyal & imath; and Alt & imath;nordu districts of Ordu province exhibited symptoms of Armillaria root rot, including complete defoliation. Diseased plants exhibited diagnostic signs on their root collars and woody roots, including white mycelial fans, extensive wood rot and rhizomorphs. A single Armillaria isolate was obtained from each of the 35 symptomatic orchards. Molecular identification, employing DNA sequencing of the large subunit (LSU) region of rDNA, the translation elongation factor subunit 1-alpha (TEF1) gene and the second largest RNA polymerase II B-subunit (RPB2) gene, identified 20 isolates as Armillaria gallica and 15 as A. mellea. Phylogenetic analyses, based on TEF1 alignments, further supported the species identification with a 100% bootstrap value. To examine genetic diversity, start codon targeted (SCoT) marker 13 was used, successfully differentiating the two Armillaria species and revealing three distinct clades. Clades I and II comprised 15 and 5 isolates of A. gallica, respectively, while Clade III contained all 15 A. mellea isolates. Pathogenicity testing on kiwifruit seedlings (cv. Hayward) revealed the ability of both A. gallica and A. mellea isolates to induce disease. Rhizomorph-producing isolates in kiwifruit seedlings displayed high virulence, inducing severe leaf necrosis and seedling mortality, while isolates lacking these structures were non-pathogenic. This study identifies the first global instance of A. gallica causing kiwifruit root rot. This finding, along with the identification of A. mellea as a causal agent in the country, highlights the emerging threat of Armillaria root rot to kiwifruit production in the region.
Armillaria Species Causing Kiwifruit Vine Decline and Root Rot in Northeastern Turkiye: a Growing Concern for Kiwifruit Health (Vol 172, E13409, 2024)
(Wiley, 2025) Turkkan, Muharrem; Bozoglu, Tugba; Dervis, Sibel; Erper, Ismail; Ozer, Goksel; 16.01. Department of Organic Agriculture / Organik Tarım Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Citation - Scopus: 1
Assessment of Correlative Digital Drawing Features in the Design Processes of Unstructured Creativity
(Ecaade-education & Research Computer Aided Architectural design Europe, 2023) Aydin, Serdar; Aydın, Serdar; Sik, Busra; Yoruk, Merve Sule; Aktas, Begum; 08.02. Department of Architecture / Mimarlık Bölümü; 08. Faculty of Engineering and Architecture / Mühendislik Mimarlık Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
This research critically challenges the conventional perception of drawings as mere technical blueprints and delves into the intricate integration of design ideation, abstraction, and speculation with geometrical manipulations and semantic labelling. By focusing on unconventional architectural design studio experiments at the undergraduate level, the study aims to explore the role of creativity in speculative drawing. It adopts a 3-dimensional design thinking process that transcends the rigid constraints of traditional drawings and embraces the fluidity of representational norms. Furthermore, the paper elucidates on the pedagogical aspects of the design studio, including the unstructured creativity inherent in the design process. The methodology employed in this study is exemplified through different stages of the design studio, incorporating a variety of representations such as 2D, 2.5D, and 3D, encompassing scalar, geometric, and material transfigurations. To assess the outcomes of the studio, the research utilises correlation diagrams that establish connections between digital drawing features at different stages and the unstructured creativity manifested in the final design. These scatter and correlation diagrams capture the syntactic relationships between the objects within digital drawings. The findings of this study reveal insight on the nuanced interplay between intuitive, reflective, and retrospective aspects of unstructured creativity during the design ideation process. By unravelling the intricate role of digital design tools and methods this research contributes to a deeper understanding of how design ideation is generated and manifested through the dynamic interplay of the modulating compounds of drawing objects. It highlights the significance of meaningful, conceptual, and speculative representations that directly relate to the creation of buildable forms and architectural spaces. Through its critical insights, this study paves the way for advancements in the field of CAAD and offers valuable perspective for architectural education and practice.
Bedouin Bureaucrats: Mobility and Property in the Ottoman Empire.
(Burhan Caglar, 2024) Ciftci, Erdal; 17.06. Department of Architecture and Urban Planning / Mimarlık ve Şehir Planma Bölümü; 17. Vocational Higher School / Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
This monograph examines the imperial nation-building process in the latter half of the nineteenth century, centering on tent-dwelling Bedouin tribes of inner Syria, predominantly in the Transjordan region. Investigating interactions among Bedouin chiefs, commercial-capitalists, urban elites, and Ottoman officials from the eighteenth to the early twentieth century, it illustrates the central role of Bedouin bureaucrats in fostering mutually beneficial relationships within or outside the state sphere.
Characterization of Durum Wheat (triticum durum L.) Landraces Regarding To Some Agronomic Traits
(Univ Namik Kemal, 2023) Durmaz, Abdurrahman; Aktas, Husnu
This research was conducted in 2019-20 wheat growing season under rainfall condition of Mardin - Artuklu province. 80 durum wheat landraces originated from Southeast Anatolia and 10 registered durum wheat cultivars were evaluated according to Augmented Trail Design. 20 landraces and 10 cultivars were used for each bloc. We determined large variations in durum wheat landraces for observed traits. Results indicated that mean of observed traits of landraces and varieties were ranged between 229 kg/da - 371 kg/da for grain yield; 1313 kg/kg - 1218 kg/kg for biomass, 18.02 % - 14.94 % for grain protein content. Mean thousand kernel weight of landraces and standard varieties changed between 42.9 g and 40.15 g; heading days ranged from 117.8 to 111 days respectively. According to observed data, landraces had longer heading days and grain stage and also higher grain protein content and biomass compare to standard varieties. Results of this study showed that landraces has high potential to increase biomass and grain protein content and they can be used as a genitor in wheat breeding programs to improving desirable durum wheat genotypes. Observation according to GGE biplot methodology (which-wonwhere) indicated that ST8 (Check) and G80 (landrace) have high values for grain yield, number of seed pers spike, seed weight per spike while G8 (landrace) showed high values for thousand grain weight, length of peduncle, plant height, grain protein content, biomass and heading days. Obtained results from this study indicated that landraces should be preserved for sustainable agriculture activities specially for marginal areas, also they have high diversity and useful traits for national and international wheat breeding programs.
Citation - WoS: 2
Citation - Scopus: 2
The Church of Virgin at Amida and the Martyrium at Constantia: Two Monumental Centralised Churches in Late Antique Northern Mesopotamia
(Mersin University, 2013) Keser-Kayaalp, E.; Keser Kayaalp, Elif; 02.11. Department of History of Art / Sanat Tarihi Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Late Antique Northern Mesopotamia, which was situated at the eastern edge of the Byzantine Empire, was dotted with important cities such as Edessa (Urfa), Anastasiopolis (Dara), Amida (Diyarbakir), Martryropolis (Silvan), Constantia (Viranşehir) and Nisibis (Nusaybin). These cities were wealthy and highly cosmopolitan. As a result, the region had a sophisticated architecture which was by no means inferior to that found in other parts of the Byzantine Empire. This article deals with two monumental centralised churches in Northern Mesopotamia, namely the Church of the Virgin at Amida and the Octagon at Constantia. It concentrates firstly on the Church of the Virgin, which is an aisled-tetraconch church, a familiar plan type repeated in different parts of the Empire, and secondly on the Octagon at Constantia which has some unique features but shares the ambulatory design, long eastern chamber, use of materials and the monumentality with the aisled-tetraconch at Amida. By contextualising these two churches together, which has not been done in the past, this paper sheds further light on these neglected structures and reconsiders their reconstructions, dating, dedications and possible prototypes.
Comparison of the Gonadoprotective Functions of Nigella Sativa Oil, Metformin and Vitamin E on Streptozotocin-Induced Diabetic Testis
(Edizioni Minerva Medica, 2025) Kaya, Seval; Seker, Ugur; Ozmen, Mehmet F.; Ayaz, Hayat; Erdogan, Gamze; Nergiz, Yusuf; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
BACKGROUND: Changes in blood glucose levels in DM cause many complications. We aimed to make a detailed comparison study on the protective effects of Nigella sativa oil, metformin, and vitamin E on the histopathologic effects of diabetes on the male reproductive system. METHODS: In the experiment, 30 rats were divided equally into 5 groups: Control, DM, DM+NS, DM+M and DM+E. To induce diabetes in the experimental groups, a one-time injection of 45 mg/kg Streptozotocin was administered. Rats with blood glucose levels above 250 mg/dl were included in the experiment. The experiment period lasted 8 weeks. Weekly body weight of the rats, reproductive organ weights at the end of the experiment, spermatologic data, immunohistochemical staining, TUNEL assay staining and morphometric evaluation were performed. RESULTS: According to Johnsen Biopsy Score and Seminiferous Tubule diameter data, the DM+NS group had similar results to the control group, indicating that Nigella sativa oil preserved the seminiferous tubule diameter structure better than vitamin E and metformin. There were head, neck and tail defects in the diabetes group. Based on the results of the applications carried out to evaluate apoptosis and proliferation in testicular tissue, it can be concluded that the treated diabetic groups, especially the Nigella sativa oil, improved the structure of spermatogenic tubules and also reduced the number of apoptotic cells, as shown by the results of the TUNEL test (P<0.05). CONCLUSIONS: We think that Nigella sativa oil is more effective on the mechanism of diabetes than other active substances and regulates metabolic changes and may be an effective therapeutic agent for diabetes treatment.
Citation - WoS: 4
Citation - Scopus: 3
Different peripheral substituted phthalocyanines: Synthesis, characterization, aggregation behavior, antioxidant and antibacterial activity
(PLEIADES PUBLISHING INC, 2015) Celebi, M.; Agirtas, M. S.; Dundar, A.; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
In this study, a novel phthalonitrile, 4-chloro-5-(2-((2-hydroxyethyl)(p-tolyl)amino)ethoxy)phthalonitrile (3), and its metallophthalocyanine derivatives (4-6) are prepared by cyclotetramerization with appropriate metal salts in dimethylformamide. The newly prepared compounds have been characterized by several spectroscopic techniques. All compounds are evaluated for their antioxidant and antibacterial potential. For the antioxidant studies, three tests are applied; DPPH (2,2-diphenyl-1-picrylhydrazylradical) scavenging, metal chelating and reducing power activity. Compound 4 exhibits the best DPPH scavenging activity as 35.2% at 100 mg/L concentration. The metal chelating activities of compounds 3 and 4 are 69.7% and 56.4%, respectively. Reducing power activities of compounds 3 and 4 are higher than alpha-tocopherol which is used as positive control. All compounds show moderate antibacterial activity when compared to the standard antibiotics, amikacin and tetracycline.
Citation - WoS: 1
Citation - Scopus: 2
distribution of Oxa-Type Carbapenemase Genes in Carbapenem-resistant Acinetobacter Baumannii strains: an Investigation by Real-Time Polymerase Chain Reaction Method
(Doc design informatics Co Ltd, 2019) Demirci, Mehmet; Yigin, Akin; Demir, Cemil; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Objective: Carbapenems are the most important broad spectrum antimicrobials used in the treatment of Acinetobacter baumannii infections, but resistance to carbapenems is increasing worldwide. In this study, we aimed to investigate the distribution of OXA-type carbapenemase genes observed in carbapenem-resistant A. baumannii strains by real-time polymerase chain reaction (PCR) method and to provide epidemiological data. Methods: Between January 2016 and January 2018, 20 carbapenem-resistant A. baumannii strains from clinical specimens were included in the study. DNA isolations were performed, and distribution of OXA-type carbapenemase genes were examined using primers and TaqMan probes specific to genes of OXA-23, OXA-24, OXA-51 and OXA-58 carbapenemases by real-time PCR method. Results: Tigecycline was the best choice for carbapenem-resistant A. baumannii strains, of which 16 (80%) were susceptible to this antimicrobial. bla(OXA-51) was detected in all strains, while bla(OXA-24) was detected in only 1 (5%) strain. Of 20 strains, 10 showed the presence of bla(OXA-23) and bla(OXA-51) simultaneously. Conclusions: Simultaneous occurence of bla(OXA-23) and bla(OXA-51 )is remarkable in terms of distribution of OXA-type carbapenemases in carbapenem-resistant A. baumannii strains. Valuable epidemiological data can be obtained by performing routine surveillance of such strains by means of techniques that can produce fast and reliable results such as real-time PCR.
Docetaxel-Loaded, Dipeptide-Functionalized Γ-Fe2o3 Magnetic Nanoparticles: Synthesis, Characterization, and Targeting To Prostate Cancer
(Wiley-VCH Verlag GmbH, 2025) Gungoren, Muhammed; Koyuncu, Ismail; Kilinc, Ersin; Baysal, Zubeyde
A new delivery system was designed and synthesized to increase the efficiency of docetaxel. For this aim, gamma-Fe2O3 was synthesized in order to give the nanoparticle the ability to be magnetic targeted. It was functionalized with citric acid to prevent clumping and maintain stability. To increase the interaction efficiency between the delivery system and the drug, leucine-glycine dipeptide and an amphiphilic polymer, Pluronic F127, were attached to the nanoparticle. Characterization studies were carried out with XRD, ICP-MS, vibrating sample magnetometer (VSM), TEM, and zeta potential to elucidate the structure of this carrier system. After docetaxel was bound to the synthesized carrier, its therapeutic effect was measured by spectrophotometric and flow cytometric methods (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide [MTT], reactive oxygen species [ROS], and apoptosis). Docetaxel-bound nanoparticles significantly reduced the viability of the tumor cell compared to the healthy cell in a dose-dependent manner, especially at 24 (50.14 +/- 13.25 to 22.32 +/- 5.51 at 100 mu g/mL) h and 48 (41.46 +/- 2.22 to 18.80 +/- 2.81 at 100 mu g/mL) h. The rate of apoptosis and ROS in the negative sample increased from 2.7% to 15.4% and from 9.6% to 74.7%, respectively, as a result of treatment with 15 mu g/mL gamma-Fe2O3/C/LG/F127/Dotx. Thus, it can be said that the synthesized carrier system is a suitable candidate for the improvement of docetaxel transport.
The Effect of Acute Carbon Monoxide Intoxication on Cardiac Necrosis in Rats: in Relation To Adiponectin Levels
(Univ Zulia, Facultad Ciencias veterinarias, 2025) Gokdemir, Gul Sahika; Cakmak, Sumeyye; Demirtas, Berjan; Gokdemir, Mehmet Tahir; Sogut, Ozgur; Canpolat-Erkan, Revsa Evin; Yokus, Beran; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
In order to investigate the effects of acute CO poisoning and subsequent oxygen therapy on cardiac necrosis in rats, with a specific focus on adiponectin levels, twenty-one male Wistar albino rats were divided into three groups (Control, CO, CO+O-2). The Control group was placed in a container and exposed to room air for 30 min. Acute CO poisoning was induced in the CO group and CO+O-2 group by exposing the rats to CO gas for 30 min. Following CO exposure, the CO+O-2 group received oxygen therapy for 30 min, while the CO group did not receive any additional intervention. The animals were euthanized by cardiac puncture under anesthesia, following the approved ethical procedures. Carboxyhemoglobin (COHb), serum levels of creatine kinase (CK), creatine kinase myocardial band (CK-MB), C-reactive protein (CRP) and lactate dehydrogenase (LDH), as well as cardiac and serum adiponectin levels were measured. CO poisoning caused necrosis in cardiac tissue however, oxygen therapy alleviated the negative effect of CO on cardiac injury. COHb and LDH levels in CO group were increased, whereas both cardiac and serum adiponectin levels were decreased (all, P<0.05). There were no changes in CK, CK-MB, CRP levels among groups (all, P>0.05). Oxygen therapy decreased COHb, but increased both cardiac and serum adiponectin levels (all, P<0.05). Adiponectin and LDH may serve as potential biomarkers for early diagnosis of cardiac necrosis caused by acute CO poisoning. The assessment or quantification of adiponectin can also be useful for the early prognosis of cardiac necrosis after oxygen therapy.
Effect of Delivery Method on Breastfeeding Status in Primiparous Mothers Within the First 24 Hours
(Springer Publishing Co, 2024) Yesil, Yesim; Oner, Serap; Celik, Gulbiye Dinc; Bay, Habibe; Eksioglu, Aysun; Turfan, Esin Ceber
Objective: This study aims to evaluate the effect of the delivery method on breastfeeding status of primiparous mothers during the first 24 hours. Methods: In this descriptive and analytical study, the sample consisted of 126 primiparous mothers with vaginal (n = 54) and cesarean (n = 72) deliveries. The research data were collected in a hospital through a personal information form and LATCH. Breastfeeding was assessed at the 6th, 12th, and 24th hours within the first 24 -hour period after the delivery. Results: A total of 83.3% of mothers with vaginal delivery started out breastfeeding in the first hour, while the rate was 43.1% for mothers with cesarean delivery. A total of 94.4% of mothers who had vaginal birth gave their babies colostrum, whereas the rate was 80.6% for mothers who had a cesarean birth. While there were no statistically significant differences in Applications 1 and 3 between the LATCH scores of mothers with vaginal and cesarean deliveries, Application 2 produced a significant difference (p < .05). Conclusions: Delivery method influenced the breastfeeding behavior and had an impact particularly on initiation of breastfeeding in the first hour.

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