Scopus İndeksli Yayınlar Koleksiyonu

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Citation - WoS: 6
Citation - Scopus: 11
Activated Carbon-Coated Iron Oxide Magnetic Nanocomposite (ionps@ctac) Loaded With Morin Hydrate for Drug-Delivery Applications
(Frontiers Media Sa, 2024) Dogan, Yusuf; Ozic, Cem; Ertas, Erdal; Baran, Ayse; Rosic, Gvozden; Selakovic, Dragica; Eftekhari, Aziz; 06.02. Department of Plant Protection / Bitki Koruma Bölümü; 06. Faculty of Agricultural Sciences and Technologies in Kızıltepe / Kızıltepe Tarım Bilimleri ve Teknolojileri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Cancer is a major disease that affects millions of people around the world every year. It affects individuals of all ages, races, and backgrounds. Since drugs used to treat cancer cannot distinguish between cancerous and healthy cells, they cause systemic toxicity along with serious side effects. Recently, controlled drug-release systems have been developed to reduce the side effects caused by anticancer drugs used for treatment. Morin is an anticancer drug with a flavonol structure. It has been extensively researched for its antioxidant, anti-inflammatory, antitumoral, and antibacterial properties, especially found in Chinese herbs and fruits, and its multiple positive effects on different diseases. In this study, a nanocomposite with magnetic properties was synthesized by coating biocompatible activated carbon obtained using the fruits of the Celtis tournefortii plant on the surface of iron oxide magnetic nanoparticles. Characterization of the synthesized activated carbon-coated iron oxide magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction, dynamic light scattering, zeta potential, and vibrating sample magnetometry. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (colorectal), T98-G (glioblastoma) cancer cell lines, and human umbilical vein endothelial cell (HUVEC) healthy cell line. The morin loading and release behavior of the activated carbon-coated iron oxide magnetic nanocomposite were studied, and the results showed that up to 60% of the adsorbed morin was released within 4 h. In summary, activated carbon-coated iron oxide magnetic nanocomposite carriers have shown promising results for the delivery of the morin drug.
Citation - WoS: 54
Citation - Scopus: 58
Adsorption and inhibition effect of 2,4-diamino-6-hydroxypyrimidine for mild steel corrosion in HCl medium: experimental and theoretical investigation
(SPRINGER HEIDELBERG, 2019) Yildiz, Resit; 09.03. Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
2,4-Diamino-6-hydroxypyrimidine (2D6H) was examined as corrosion inhibitor of mild steel (MS) in 0.1M HCl using potentiodynamic measurements, linear polarization resistance (LPR), scanning electron microscopy, electrochemical experiments, and quantum chemical calculations. All measurements show that the corrosion inhibition effectiveness is forthright compared to the concentration of 2D6H ranging from 0.5 to 10.0mM. Adsorption of 2D6H on the MS surface in the presence of HCl is determined to obey Langmuir adsorption isotherm. The electronic features elucidated by quantum chemical calculations were associated with the experimental inhibition productivities. The mechanism of inhibition was revealed by E-pzc measurements.
Citation - WoS: 2
Citation - Scopus: 2
Air Quality Forecasting Using Machine Learning: Comparative Analysis and Ensemble Strategies for Enhanced Prediction
(Springer Int Publ Ag, 2025) Ozupak, Yildirim; Alpsalaz, Feyyaz; Aslan, Emrah; 08.01. Department of Computer Engineering / Bilgisayar Mühendisliği Bölümü; 08. Faculty of Engineering and Architecture / Mühendislik Mimarlık Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Air pollution poses a critical challenge to environmental sustainability, public health, and urban planning. Accurate air quality prediction is essential for devising effective management strategies and early warning systems. This study utilized a dataset comprising hourly measurements of pollutants such as PM2.5, NOx, CO, and benzene, sourced from five metal oxide sensors and a certified analyzer in a polluted urban area, totaling 9,357 records collected over one year (March 2004-February 2005) from the Kaggle Air Quality Data Set. A comprehensive comparison of ten machine learning regression models XGBoost, LightGBM, Random Forest, Gradient Boosting, CatBoost, Support Vector Regression (SVR) with Bayesian Optimization, Decision Tree, K-Nearest Neighbors (KNN), Elastic Net, and Bayesian Ridge was conducted. Model performance was enhanced through Bayesian optimization and randomized cross-validation, with stacking employed to leverage the strengths of base models. Experimental results showed that hyperparameter optimization and ensemble strategies significantly improved accuracy, with the SVR model optimized via Bayesian optimization achieving the highest performance: an R2 score of 99.94%, MAE of 0.0120, and MSE of 0.0005. These findings underscore the methodology's efficacy in precisely capturing the spatial and temporal dynamics of air pollution.
Citation - WoS: 9
Citation - Scopus: 11
Allelic variations of glutenin subunits and their association with quality traits in bread wheat genotypes
(2017) Aktaş, Hüsnü; Baloch, Faheem Shehzad; 16.02. Department of Seed Production / Tohumculuk Teknolojisi Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The present study was conducted to evaluate the genotype × environment interaction of the yield and quality traits for five bread wheat varieties commonly grown in the Southeastern Anatolia Region of Turkey and 20 advanced lines developed within the framework of the International Winter Wheat Improvement Project. We also determined the allelic pattern of the Glu-1 and Glu-3 loci of these genotypes and examined whether these loci had an effect on the quality traits. There was a significant variation among the genotypes and environments in terms of grain yield, protein content, sedimentation volume (SV), and the extensograph dough energy value (EDEV). The results of the study indicated that genotypic effect was more influential on SV and EDEV than environmental effect; thus, both traits could be used in breeding programs to develop elite cultivars with better quality. Twelve different high-molecularweight (HMW) glutenin alleles were identified at the Glu-A1, Glu-B1, and Glu-D1 loci, resulting in 14 allelic combinations, and 17 different alleles were observed in 19 combinations for low-molecular-weight (LMW) subunits. Furthermore, among all the genotypes, 13 + 16 and 13 + 19 alleles at Glu-B1 and 5 + 12 at Glu-D1 were observed to have the lowest frequency. Our study indicated that the combinations of HMW glutenin alleles with 2* at Glu-A1, 17 + 18 and 13 + 16 at Glu-B1, and 5 + 10 at Glu-D1, as well as the combinations of LMW alleles with subunits c and d at Glu-A3; subunits d, b, c, and g at Glu-B3; and subunits a and b at Glu-D3 had positive effects on the quality traits.
Ameliorative Effects of Agomelatine Against Doxorubicin-Induced Hepatotoxicity
(BMC, 2025) Savas, Hasan Basri; Sozen, Mehmet Enes; Cuce, Gokhan; Batur, Tuba
Drug-induced hepatotoxicity is a significant impediment to the use of doxorubicin, a commonly employed chemotherapeutic agent with established efficacy in cancer treatment. The present study aimed to determine the potential protective effects of agomelatine against doxorubicin hepatotoxicity in rat toxicity models. Thirty-two rats were divided into four groups: control (with saline administration), Doxo (with 40 mg/kg doxorubicin administration), Doxo + Ago20, and Doxo + Ago40 (with 20 and 40 mg/kg agomelatine administration and 40 mg/kg doxorubicin administration). On the day of 14 rats were sacrificed, samples were collected for comparison of immunohistochemical, hematological, and biochemical analysis. There were statistically significant differences between the study groups in terms of immunohistochemical, hematological, and biochemical parameters. Agomelatine administration reduced the TNF-alpha, and caspase-3, which increased by doxorubicin, and reversed levels of oxidative stress markers altered by doxorubicin (p < 0.05). Doxorubicin induces oxidative stress, apoptosis, and hepatotoxicity. Agomelatine may be favored as a primary antidepressant to mitigate hepatic damage induced by doxorubicin.
Citation - WoS: 28
Citation - Scopus: 34
An analysis of age-standardized suicide rates in Muslim-majority countries in 2000-2019
(BMC Public Health, 2022) Zeyrek-Rios, Emek Yüce; Bob Lew; Lester, David; Kõlves, Kairi; Yip, Paul S. F.; Ibrahim, Norhayati; 02.10. Department of Psychology / Psikoloji Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background: This study examines the 20-year trend of suicide in 46 Muslim-majority countries throughout the world and compares their suicide rates and trends with the global average. Ecological-level associations between the proportion of the Muslim population, the age-standardized suicide rates, male-to-female suicide rate ratio, and the Human Development Index (HDI) in 2019 were examined. Methods: Age-standardized suicide rates were extracted from the WHO Global Health Estimates database for the period between 2000 and 2019. The rates in each country were compared with the age-standardized global average during the past 20 years. The countries were further grouped according to their regions/sub-regions to calculate the regional and sub-regional weighted age-standardized suicide rates involving Muslim-majority countries. Correlation analyses were conducted between the proportion of Muslims, age-standardized suicide rate, male: female suicide rate ratio, and the HDI in all countries. Joinpoint regression was used to analyze the age-standardized suicide rates in 2000-2019. Results: The 46 countries retained for analysis included an estimated 1.39 billion Muslims from a total worldwide Muslim population of 1.57 billion. Of these countries, eleven (23.9%) had an age-standardized suicide rate above the global average in 2019. In terms of regional/sub-regional suicide rates, Muslim-majority countries in the Sub-Saharan region recorded the highest weighted average age-standardized suicide rate of 10.02/100,000 population, and Southeastern Asia recorded the lowest rate (2.58/100,000 population). There were significant correlations between the Muslim population proportion and male-to-female rate ratios (r=-0.324, p=0.028), HDI index and age-standardized suicide rates (r=-0.506, p<0.001), and HDI index and male-to-female rate ratios (r=0.503, p<0.001) in 2019. Joinpoint analysis revealed that seven Muslim-majority countries (15.2%) recorded an increase in the average annual percentage change regarding age-standardized suicide rates during 2000-2019. Conclusions: Most Muslim-majority countries had lower age-standardized suicide rates than the global average, which might reflect religious belief and practice or due to Muslim laws in their judicial and social structure which may lead to underreporting. This finding needs further in-depth country and region-specific study with regard to its implication for public policy.
Citation - WoS: 5
Citation - Scopus: 9
Animals and pastoral groups in the mountainous Ömerli district of Southeast Anatolia
(Taylor and Francis Ltd., 2020) Sıddıq, Abu Bakar; Şanlı, Süleyman; 02.01. Department of Anthropology / Antropoloji Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Southeast Anatolia has been an ideal place for pastoralism since the Neolithic period. However, there is a lack of information on human–animal relationships from both archaeological settlements and contemporary societies in the region. Through ethnographic fieldwork and exploratory case studies in the mountainous Ömerli district, we explored the dependency and complex relationships between pastoral groups and various animal species in Southeast Anatolia. The case studies revealed affectionate and emotional bonds between shepherds and some individuals of domestic herds, similar to pet–human relationships in urban societies. Shepherds gave human names to certain animals; sometimes these were the names of their close friends or the names of their own children. Grief and prolonged grief was also common among Ömerli shepherds following the loss, death, or sale of these emotionally bonded animals. It was further observed that a single species (domestic or wild) often had complex and multi-purpose relationships with shepherd groups. While tortoises and hares, for instance, were used as sources of meat, the bone, blood, intestine, skin, and shell of these species were often used in traditional medicine. Although pastoral groups are completely dependent on domestic herds for their basic subsistence, Ömerli shepherds were observed to be regular hunters. It appears that the economic benefits were not the only promoters for pastoral subsistence in the study area; compassion and emotional affection for particular animals also reinforced enthusiasm for the practice. Therefore, it can be argued that the data obtained from pastoral villages in the mountainous Ömerli district help us understand interactions and relationships between humans and nonhuman animals in pastoral societies of Southeast Anatolia.
Citation - WoS: 21
Citation - Scopus: 27
Antibiotic Removal from the Aquatic Environment with Activated Carbon Produced from Pumpkin Seeds
(Molecules, 2022) Alacabey, İhsan; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Antibiotics are among the most critical environmental pollutant drug groups. Adsorption is one of the methods used to eliminate these pollutants. In this study, activated carbon was produced from pumpkin seed shells and subsequently modified with KOH. The adsorbent obtained through this procedure was used to remove ciprofloxacin from aqueous systems. Fourier Transform-Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), elemental, X-ray Photoelectron Spectroscopy (XPS), Brunauer–Emmett–Teller (BET) and Zeta analyses were used to characterize the adsorbent. The surface area, in particular, was found to be a very remarkable value of 2730 m2/g. The conditions of the adsorption experiments were optimized based on interaction time, adsorbent amount, pH and temperature. Over 99% success was achieved in removal operations carried out under the most optimal conditions, with an absorption capacity of 884.9 mg·g−1. In addition, the Langmuir isotherm was determined to be the most suitable model for the adsorption interaction
Antidepressant-Like Effects of Ashwagandha (Withania Somnifera) on Chronic Unpredictable Mild Stress-Induced Depression in Adolescent Rats
(Springer, 2025) Gokdemir, Gul Sahika; Seker, Ugur; Baksi, Nazan; Baylan, Mukadder; Demirtas, Berjan; Gokdemir, Mehmet Tahir; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
RationaleAdolescent depression is often linked to biological changes associated with stress. However, new approaches and treatment strategies for early intervention and prevention of depression in children and adolescents are still limited. Ashwagandha is an Ayurvedic herb widely used in the management of anxiety and stress. However, there is no information in the current literature on its potential effect on adolescent depression.ObjectivesThis study aimed to investigate the effects of depression on proapoptotic proteins and neuroinflammation and the antidepressant effect of Ashwagandha on depression-like symptoms in adolescent rats exposed to the Chronic Unpredictable Mild Stress (CUMS) model.MethodsIn the study, CUMS model was used to induce depression in adolescent rats. Rats were treated with Ashwagandha or Sertraline. To evaluate the antidepressant effects, behavioral tests as well as biochemical and histological analyses were performed. Forced Swim Test (FST), Sucrose Test and Elevated Plus Maze Test were performed as behavioral tests. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were measured by the ELISA method in the fronto-parietal cortex. Proapoptotic proteins (Bax and Caspase-3) and inflammatory markers (TNF-alpha and IL-1 beta), as well as glial fibrillary acidic protein (GFAP), were evaluated immunohistochemically in the fronto-parietal cortex.ResultsProapoptotic proteins (Bax and Caspase-3) and inflammatory markers (TNF-alpha and IL-1 beta) were increased in the CUMS group. BDNF and GFAP levels were decreased. Ashwagandha treatment was more effective than Sertraline in reducing the levels of these proteins and markers. Additionally, Ashwagandha prevented weight loss.ConclusionsAshwagandha showed antidepressant-like effects in adolescent rats, reducing apoptosis, inflammation, and neuroinflammation, suggesting potential for treating adolescent depression.
Citation - WoS: 1
Citation - Scopus: 1
Assessment of Iron Metabolism and Inflammation in Children With Cerebral Palsy
(Mdpi, 2025) Orhan, Ozhan; Gokdemir, Gul Sahika; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü; 10. Faculty of Medicine / Tıp Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Background/Objectives: Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. Methods: A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. Results: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children (p < 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Conclusions: Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients.
Citation - WoS: 5
Citation - Scopus: 5
Assessment of Walnut (juglans Regia L.) Cultivation Land Suitability Using a Multiple-Criteria Decision-Making Method in Southeastern Turkey
(Nature Portfolio, 2025) Mercan, Cagri; 17.06. Department of Architecture and Urban Planning / Mimarlık ve Şehir Planma Bölümü; 17. Vocational Higher School / Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Site selection for agricultural products is critical for agricultural planning, productivity, and farmers. Site selection is also critical for agricultural sustainability, as it helps ensure the efficient use of natural resources and avoids environmental degradation. This research proposes an evaluation model for walnut cultivation in the Savur (Mardin, Turkey) district in the Southeastern Anatolia region. Based on literature data, expert opinion, and local walnut producers' perspectives, a spatial decision support system was developed using Geographic Information System (GIS)-based Multi-Criteria Decision Analysis (MCDA). This model provides farmers and stakeholders with a comprehensive evaluation of the different walnut-producing sites in the Savur district. It allows them to make informed decisions about the most suitable areas for walnut production. The land suitability assessment for walnut orchards included four primary evaluation aspects, ten main criteria, and forty-seven sub-criteria. Evaluation criteria were weighted using the Analytic Hierarchy Process (AHP). A land suitability map was created using the weighted overlay method in overlap with the evaluation criteria. The results showed 442.56 ha of very highly suitable land, 9789.43 ha of highly suitable land, and 1140.76 ha of moderately suitable land in the Savur district. In order to determine the accuracy of the study model, ROC (Receiver Operating Characteristic) analysis was conducted. As a result of the validation analysis, the constructed model had an Area Under the Curve (AUC) of 0.911, which indicates an excellent fit between the model and reality; therefore, the model is acceptable. This study demonstrates that integrating AHP and GIS can aid agricultural land use planning and decision-making.
The Association Between Self-Esteem and Physical Aggression in Elementary School Students in Türkiye: the Role of Being a Victim as Mediator
(Springer, 2025) Kocak, Orhan; Semerci, Melike; Aslan, Yavuz; 09.05. Department of Child Development / Çocuk Gelişimi Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Childhood and early adolescence play a crucial role in shaping individuals' attitudes and behaviours through the cultivation of self-esteem. While this dynamic may differ among various age groups, self-esteem is anticipated to serve as a protective factor against peer bullying and aggression, particularly within the school setting. The present study aimed to explore the associations between self-esteem, experiences of victimisation, and engagement in physical aggression. This research, structured as a cross-sectional quantitative inquiry, involved administering an online survey to 445 primary and middle school students in T & uuml;rkiye. Descriptive and correlation analysis was performed with the SPSS 22.0 program, and mediation analysis was performed with the IBM AMOS 24 program. Being a victim was found to have a mediating effect on the relationship between self-esteem and physical aggression. Self-esteem reduces physical aggression by reducing being a victim. In this context, educators and policymakers need to focus their efforts to increase self-esteem while developing programs to prevent peer bullying and aggression in schools.
Automated Mucormycosis Diagnosis from Paranasal CT Using ResNet50 and ConvNeXt Small
(MDPI, 2025) Toprak, Serdar Ferit; Dedeoglu, Serkan; Kozan, Gunay; Ayral, Muhammed; Can, Sermin; Turk, Omer; Akdag, Mehmet
Purpose: Mucormycosis is a life-threatening fungal infection, where rapid diagnosis is critical. We developed a deep learning approach using paranasal computed tomography (CT) images to test whether mucormycosis can be detected automatically, potentially aiding or expediting the diagnostic process that traditionally relies on biopsy. Methods: In this retrospective study, 794 CT images (from patients with mucormycosis, nasal polyps, or normal findings) were analyzed. Images were resized and augmented for training. Two transfer learning models (ResNet50 and ConvNeXt Small) were fine-tuned to classify images into the three categories. We employed a 70/30 train-test split (with five-fold cross-validation) and evaluated performance using accuracy, precision, recall, F1-score, and confusion matrices. Results: The ConvNeXt Small model achieved 100% accuracy on the test set (precision/recall/F1-score = 1.00 for all classes), while ResNet50 achieved 99.16% accuracy (precision approximate to 0.99, recall approximate to 0.99). Cross-validation yielded consistent results (ConvNeXt accuracy similar to 99% across folds), indicating no overfitting. An ablation study confirmed the benefit of transfer learning, as training ConvNeXt from scratch led to lower accuracy (similar to 85%) Conclusions: Our findings demonstrate that deep learning models can accurately and non-invasively detect mucormycosis from CT scans, potentially flagging suspected cases for prompt treatment. These models could serve as rapid screening tools to complement standard diagnostic methods (histopathology), although we emphasize that they are adjuncts and not replacements for biopsy. Future work should validate these models on external datasets and investigate their integration into clinical workflows for earlier intervention in mucormycosis.
Barrow Entropic Cosmology with Exponential Potential Field
(World Scientific, 2024) Karabat, M. Faruk
In this paper, we consider an exponential potential V(φ)=V0e-αφ in the framework of Barrow entropy under the constant-roll inflation and check their viability in the light of observable Planck 2020 data. By applying the first law of thermodynamics to the apparent horizon of the Universe, a modification of the Friedmann-Robertson-Walker (FRW) metric is derived in the context of Barrow entropy. We consider the early inflationary period of the universe to consist phenomenologically of a single inflationary state, that is, a state of the costant-roll inflation in which inflation is driven by an exponential potential field function. By fitting the constant-roll inflationary models to the observations, we examined the effect of the Barrow parameter Δ on the inflation mechanism with the constant-roll parameter γ. As a result, we concluded that for a viable inflation, the observation limits of the inflation parameters determine that the constant-roll parameter is in the range 0.011≤γ≤0.016. © 2024 Elsevier B.V., All rights reserved.
Citation - Scopus: 1
Biological assays, electrochemical behavior, and theoretical DFT calculations of Ru(II) complexes of chiral phosphinite based based on β-amino alcohols: Transfer hyrogenation of ketones using a HCOOH/Et3N mixture
(Elsevier, 2024) Rafikova, Khadichakhan; Meriç, Nermin; Ertekin Binbay, Nil; Okumuş, Veysi; Sever, M. Şerif; Belyankova, Yelizaveta; Tursynbek, Saniya; Dauletbakov, Anuar; Sarah, Bayazit; Zolotareva, Darya; Yerassyl, Kamshyger; Dündar, Abdurahman; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Synthesis of two phosphinite ligands based on β-amino alcohols, in high yields has been demonstrated. When we treated [Ru(arene)(μ-Cl)Cl]2 {arene:p-cymene,benzene} with chelating phosphinite ligands, we obtained neutral Ru(II)-complexes possessing the general formula [Ru(arene)phosphiniteCl2]. The structure of the ligands and complexes was confirmed using analytical and spectroscopic techniques. The quantum chemical calculations were carried out for the ruthenium complexes at the DFT/CAM-B3LYP level of theory in gas phase. The phosphinite complexes were subjected to cyclic voltammetry studies in order to determine the energies of HOMO and LUMO levels and to estimate their electrochemical and some electronic properties. Organic complex-based memory substrates were immobilized using TiO2-modified ITO electrodes, and the memory functions of phosphinite-based organic complexes were verified by chronoamperometry (CA) and open-circuit potential amperometry (OCPA). In the present study, the antioxidant potentials of ruthenium-based p-cymene and benzene complexes through DPPH radical scavenging, metal chelating, and reducing power activities were also determined. In addition, DNA binding abilities and antimicrobial activities of these complexes against pathogenic bacteria were studied. Finally, the ruthenium complex, (2S)-1-{[(2S)-2-[(diphenylphosphanyl)oxy]propyl][(1R)-1-phenylethyl]amino}propan-2-yldiphenyl phosphinitobis[dichloro(η6-benzene)ruthenium(II)] also catalyzed asymmetric transfer hydrogenation of acetophenone with high conversion (up to 99%) and good enantioselectivity (ee up to 89 %), in the existence of formic acid and triethylamine in dichloromethane medium under air atmosphere.
Biological Effect of Thiazole-Containing Zinc(II) Phthalocyanine on Different Sizes of Gold Nanoparticles
(Amer Chemical Soc, 2025) Ozturk, Nazli Farajzadeh; Uzunmehmetoglu, Hilal Zengin; Yenilmez, Hacer Yasemin; Ozdemir, Sadin; Dundar, Abdurrahman; Bayir, Zehra Altuntas; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
This study aims to design multidisciplinary bioagents for a wide range of biological applications. The synthesis and characterization of 4,5-bis((4-phenylthiazol-2-yl)thio)phthalonitrile (a) and its octa-substituted zinc(II) phthalocyanine derivative (b) were described in this study. Additionally, gold nanoparticles were synthesized in three different sizes, including 10 nm (1), 45 nm (2), and 80 nm (3). Macromolecule (b) was used for surficial functionalization of gold nanoparticles (1-3) to prepare nanoconjugates (1-3b). Antioxidant, antimicrobial, antibacterial, antibiofilm, antidiabetic, and deoxyribonucleic acid (DNA) cleavage activities of biocandidates (b, 1-3, and 1-3b) were examined to determine the optimum size of gold nanoparticles and the effect of modifying groups on their bioactivity in this study for the first time. The highest antioxidant activities were obtained for biocandidates (b and 1b) at 100 mg/L. The best minimum inhibitory concentration (MIC) values were obtained at 32 mg/L for bioagents (b, 1, and 3b) against E. faecalis whereas the MIC value was obtained at 32 mg/L for 1b against E. hirae and E. faecalis. Bioagents (b and 1-3b) exhibited high APDT activities (16 mg/L) against the studied microorganisms. The highest biofilm inhibition activities were obtained 94.57 and 89.28% for 50 mg/L nanoconjugate (1b) against S. aureus and P. aeruginosa, respectively. All the studied biocandidates inhibited 100% E. coli viability at 50 mg/L. The antidiabetic activities of biocandidates (b, 1-3, and 1-3b) were obtained between 7.52 and 100 mg/L. Bioagents (2, 3, 1b, and 2b) destroyed the DNA integrity, as well. The significant improvement in the biological activities of gold nanoparticles confirmed that new nanoconjugates especially 1b can be considered promising medical nanomaterials after further clinical investigation.
Citation - WoS: 60
Citation - Scopus: 76
Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract
(Elsevier, 2023) Xu, Jiujun; Yıldıztekin, Mahmut; Han, Dayong; Keskin, Cumali; Baran, Ayşe; Baran, Mehmet Fırat; Eftekhari, Aziz; Aytuğ Ava, Canan; İrtegün Kandemir, Sevgi; Cebe, Deniz Barış; Dağ, Beşir; Beilerli, Aferin; Khalilov, Rovshan; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Metallic nanoparticle biosynthesis is thought to offer opportunities for a wide range of biological uses. The green process of turning biological waste into utilizable products gaining attention due to its economical and eco-friendly approach in recent years. This study reported the ability of Solanum tuberosum (ST) peel extract to the green synthesis of non-toxic, stable, small-sized silver nanoparticles without any toxic reducing agent utilizing the phytochemical components present in its structure. UV-visible spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, flourier scanning electron microscopy, atomic force microscopy, transmission electron microscopy, and energy dispersive analysis X-ray confirmed the biosynthesis and char-acterization of silver nanoparticles. Also, dynamic light scattering and thermogravimetric ana-lyses showed stable synthesized nanoparticles. The antibacterial activity of the biosynthesized silver nanoparticles was evaluated against four different bacterial strains, Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) Bacillus subtilis (B. subtilis), and a yeast, Candida albicans (C. albicans) using the minimum inhibitory concen-tration technique. The cytotoxic activities were determined against Human dermal fibroblast (HDF), glioblastoma (U118), colorectal adenocarcinoma (CaCo-2), and human ovarian (Skov-3) cell lines cancer cells using MTT test. The nanoparticle capping agents that could be involved in the reduction of silver ions to Ag NPs and their stabilization was identified using FTIR. Nano -particles were spherical in shape and had a size ranging from 3.91 to 27.07 nm, showed crys-talline nature, good stability (-31.3 mV), and the presence of capping agents. ST-Ag NPs significantly decreased the growth of bacterial strains after treatment. The in vitro analysis showed that the ST-Ag NPs demonstrated dose-dependent cytotoxicity against cell lines. Based on the data, it is feasible to infer that biogenic Ag NPs were capped with functional groups and demonstrated considerable potential as antibacterial and anticancer agents for biomedical and industrial applications.
Boncuklu Tarla: Production and Social Dynamics of a Middle PPNB Knapped Stone Workshop (Mardin/Türkiye)
(Routledge Journals, Taylor & Francis Ltd, 2025) Erbil, Esref; Kodas, Ergul; 02.03. Department of Archaeology / Arkeoloji Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Boncuklu Tarla, located about 2 kilometres west of the Tigris River, is one of the few sites continuously occupied throughout the entire Pre-Pottery Neolithic Period. This site offers key insights into the evolving techniques and typologies of knapped stone tool production during the Neolithisation process. In 2017, excavations revealed a knapped stone workshop on the floor of a domestic structure, dated to the Middle PPNB. A total of 2,067 artefacts-including cores, flakes, debris, and unprocessed raw material-were found in situ, stacked together. Of these, 1,564 pieces are flint and 503 are obsidian. The finds are especially significant for understanding the use of pressure flaking techniques. Detailed typological and technological analyses, supported by experimental studies, have helped reconstruct all stages of the cha & icirc;ne op & eacute;ratoire in this production context. The Boncuklu Tarla assemblage contributes important data on Neolithic craft specialization and the organization of lithic production within domestic spaces.
Citation - WoS: 18
Citation - Scopus: 20
Canker and leaf scorch on olive (Olea europaea L.) caused by Neoscytalidium dimidiatum in Turkey
(ScienceDirect, 2022) Güney, İnci Güler; Özer, Göksel; Türkölmez, Şahimerdan; Derviş, Sibel; 16.01. Department of Organic Agriculture / Organik Tarım Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
In a recent survey of olive groves in the Southeast Anatolia Region of Turkey, a new and serious decline of olive trees, beginning with foliar scorching and then dieback of twigs, branches, and even whole trees, was observed for the first time. In more advanced stages of the disease, necrosis and cankers were observed on the bark of the trunk, branches, and twigs. Isolations from symptomatic tissues from multiple cultivars in diverse locations yielded Neoscytalidium dimidiatum, which were identified using ITS, tef1, and tub2 loci of genomic DNA, in combination with morphological data. In vitro studies showed that conidial germination, hyphal growth, and pycnidia formation of the pathogen were positively correlated with elevated temperatures. Wild type olive “Delice”, “Edincik Su”, and “Memecik” seemed like the most resistant cultivars on which disease severity values were the lowest among 14 screened olive cultivars in two experimental orchards under natural conditions. Pathogenicity tests showed that “Gemlik” was the most susceptible cultivar showing the largest cankers and extensive scorch lesions. Isolates caused canker but not leaf scorch on O. europaea cultivars “Arbequina” “Halhalı”, “Manzanilla”, “Nizip Yağlık”, and “Saurani”. Neoscytalidium isolates are likely to have a negative impact on the health of diverse olive groves, which are primarily confined to Mediterranean-type climatic regions. These findings suggest an increased risk of infection in environments with increasing temperatures, as is common in the Southeast Anatolia Region of Turkey. The information gathered in this study will be used to examine the disease's epidemiology and establish disease control initiatives. This is also the first report of N. dimidiatum infecting O. europaea in the world.
Carbonates and Bicarbonates: a Sustainable Approach for Managing Plant Diseases, Pests, and Abiotic Stresses
(Academic Press Ltd- Elsevier Science Ltd, 2025) Turkkan, Muharrem; Ozer, Goksel; Taheri, Parissa; Dervis, Sibel; 16.01. Department of Organic Agriculture / Organik Tarım Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
The growing global food demand necessitates sustainable agricultural practices that minimize environmental impact while ensuring high yields. Synthetic pesticides, while crucial for crop protection, raise concerns about environmental contamination, resistance development, and harm to non-target organisms. Carbonates and bicarbonates (e.g., NaHCO3, KHCO3, CaCO3) offer a promising, Generally Recognized as Safe (GRAS) alternative for integrated pest and disease management and abiotic stress mitigation. These compounds exhibit broadspectrum efficacy against diverse fungal, oomycete, bacterial, and insect pathogens, including the clubroot protist (Plasmodiophora brassicae). Their direct antimicrobial mechanisms involve disrupting pathogen cell membranes and walls, inducing osmotic stress, and altering pH, which leads to pathogen death. Beyond direct toxicity, carbonates and bicarbonates also elicit plant defenses, inducing systemic acquired resistance (SAR) and stimulating defense enzymes (e.g., peroxidase, polyphenol oxidase). Furthermore, they enhance soil health by raising pH, improving nutrient availability, structure, and water retention, while reducing heavy metal bioavailability. These soil improvements increase plant resilience to drought, salinity, and metal toxicity, with potential benefits also arising from improved stomatal regulation. Recent advancements have introduced carbonate nanoparticles as nano-fungicides and biostimulants, offering enhanced efficacy at lower application rates. Integrating carbonates/bicarbonates into Integrated pest management (IPM) programs, especially in combination with biocontrol agents and other beneficial salts, demonstrates synergistic effects and reduces reliance on conventional pesticides. However, further research is needed to elucidate detailed molecular mechanisms, assess long-term soil impacts, optimize application methods (e.g., foliar sprays, soil amendments, nanoformulations), and evaluate compatibility with other agrochemicals. Addressing these knowledge gaps will enable the full potential of these sustainable compounds for resilient and food-secure agriculture.

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