Alacabey, İhsan
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Alacabey, Ihsan
Job Title
Doçent
Email Address
ihsanalacabey@hotmail.com
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Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
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Sustainable Development Goals
1
NO POVERTY
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
13
CLIMATE ACTION
0
Research Products
2
ZERO HUNGER
0
Research Products
4
QUALITY EDUCATION
0
Research Products
3
GOOD HEALTH AND WELL-BEING
2
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
5
GENDER EQUALITY
0
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
10
REDUCED INEQUALITIES
0
Research Products
14
LIFE BELOW WATER
1
Research Products
11
SUSTAINABLE CITIES AND COMMUNITIES
2
Research Products
15
LIFE ON LAND
0
Research Products
6
CLEAN WATER AND SANITATION
3
Research Products
Documents
14
Citations
469
h-index
9
Documents
13
Citations
422
Scholarly Output
17
Articles
15
Views / Downloads
6/2
Supervised MSc Theses
1
Supervised PhD Theses
0
WoS Citation Count
208
Scopus Citation Count
231
WoS h-index
8
Scopus h-index
8
Patents
0
Projects
1
WoS Citations per Publication
12.24
Scopus Citations per Publication
13.59
Open Access Source
12
Supervised Theses
1
| Journal | Count |
|---|---|
| Molecules | 2 |
| Scientific Reports | 2 |
| Environmental Research, Engineering and Management | 1 |
| Environmental Science and Pollution Research | 1 |
| Frontiers in Chemistry | 1 |
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17 results
Scholarly Output Search Results
Now showing 1 - 10 of 17
Moving Image Determination of Hair and Serum Metal Levels in Petrol Station Workers(2019) Kömüroğlu, Ahmet Ufuk; Alacabey, İhsan; Atasoy, Nurhayat; Üçler, Rıfkı; Atasoy, Asst. Prof. Dr. NurhayatThe aim of this study is to determine some metals in hair and serum samples of petrol station workers. A total of 50 petrol station workers (exposure group) and 50 office workers (control group) were included in the study. Li, Ni, V, Tl, Ti and Sr levels in hair samples and Sr, Ti and V levels in serum samples were measured using the ICP-OES instrument. Li, Ni, V, Tl, Ti and Sr levels in hair samples were found to be significantly higher in the exposure group than in the control group. Ti level in serum samples was found to be significantly higher in the exposure group than in the control group. However, Sr and V levels in serum samples did not differ significantly between the two groups. These results show that petrol station workers are exposed to these toxic metals. For this reason, it may be recommended that petrol station workers should undergo regular biomonitoring and healthcare screening.Article Cryogel-Immobilized Catalase as a Biocatalyst with Enhanced Stability Against Microplastics(MDPI, 2025) Erol, Kadir; Alkan, Mehmet Huseyin; Alacabey, IhsanCatalase is a pivotal antioxidant enzyme that decomposes hydrogen peroxide and reduces oxidative stress. However, its low thermal and operational stability limits applications in challenging environments, particularly those contaminated with emerging pollutants such as polystyrene-based microplastics (PS-MPs). In this study, cryogels composed of Poly(2-hydroxyethyl methacrylate-co-allyl glycidyl ether) [Poly(HEMA-co-AGE)] were synthesized and evaluated as immobilization matrices to enhance catalase stability. Cryogels containing varying AGE concentrations were characterized using FT-IR, SEM, TEM, TGA, and BET analyses. The formulation with 250 mu L AGE exhibited optimal physicochemical properties, including improved water retention, increased surface area, and high immobilization capacity (356.3 mg center dot g(-1)). Immobilized catalase maintained superior activity under PS-MP-induced stress across a range of concentrations (0-1.0 mg center dot mL(-1)), temperatures (4-60 degrees C), and exposure times (up to 5 h). Kinetic modeling revealed a significant improvement in substrate affinity, with Km decreasing from 54.9 to 17.1 mM, while Vmax decreased moderately. Long-term stability tests showed that immobilized catalase retained similar to 80% activity after 70 days at 4 degrees C and 55% after 15 reuse cycles. Desorption studies confirmed the reusability of the cryogel system. These findings suggest that Poly(HEMA-co-AGE) cryogels provide a robust and reusable platform for catalase stabilization, offering potential for applications such as wastewater treatment and biosensing in microplastic-contaminated systems.Article Engineering Polyethylenimine-Metal Functionalized Cryogels for Superior Catalase Binding, Activity, and Long-Term Durability(Nature Portfolio, 2026) Alkan, Mehmet Huseyin; Erol, Kadir; Alacabey, IhsanCryogels with interconnected macroporous architectures offer significant advantages as enzyme immobilization supports due to their high permeability, mechanical robustness, and tunable surface chemistry. In this study, a novel Poly(HEMA-co-GMA) cryogel was synthesized and subsequently modified through polyethyleneimine (PEI) grafting and transition-metal chelation to create high-affinity matrices for catalase immobilization. Among the metal ions tested with Cu(II), Ni(II), and Co(II), the Cu(II)-functionalized cryogel exhibited superior physicochemical properties, including the highest water retention capacity (438.4%), well-preserved porosity, and strong coordination interactions with amine-rich PEI domains. FT-IR, SEM, TGA, BET, elemental analysis, and ICP-OES results confirmed successful stepwise modification and metal loading. Catalase immobilization studies revealed that the Poly(HEMA-co-GMA)-PEI-Cu(II) cryogel achieved the highest enzyme loading (391.9 mg & centerdot;g(-)& sup1;), with an optimal immobilization time of 8 h and optimum pH near neutrality. Kinetic analysis demonstrated a substantial decrease in K-m (from 57.3 to 14.4 mM), indicating enhanced substrate affinity, while k(cat)/K-m increased 2.8-fold relative to the free enzyme. The immobilized catalase exhibited improved thermal tolerance, strong operational stability (34.2% activity after 15 cycles), high desorption efficiency (96% in the first cycle), and markedly superior storage stability (62.1% activity after 70 days at 4 degrees C) compared to its free counterpart. These results validate the Cu(II)-chelated Poly(HEMA-co-GMA)-PEI cryogel as a highly efficient and reusable biocatalytic platform with significant potential for industrial and environmental enzyme-based applications.Article Citation - WoS: 7Citation - Scopus: 7Efficient Removal of Ciprofloxacin From Water Using High-Surface Activated Carbon Derived From Rice Husks: Adsorption Isotherms, Kinetics, and Thermodynamic Evaluation(MDPI, 2025) Demirdag, Esra; Demirel, Mehmet Ferit; Benek, Veysel; Dogru, Elif; Onal, Yunus; Alkan, Mehmet Huseyin; Alacabey, IhsanActivated carbon is widely recognized as an effective material for removing pollutants, especially pharmaceutical residues, from water. In this study, high-surface-area activated carbon derived from rice husks (RHAC) was synthesized via KOH activation and used for the adsorption of ciprofloxacin, a widely used fluoroquinolone antibiotic. Its adsorption behavior was systematically investigated through batch experiments varying the pH, adsorbent dosage, contact time, initial concentration, and temperature. The RHAC exhibited a high surface area of 1539.7 m(2)/g and achieved a maximum adsorption capacity of 398.4 mgg(-1). The Freundlich isotherm best describes its adsorption equilibrium, suggesting multilayer adsorption on a heterogeneous surface. Kinetic modeling revealed that the adsorption process followed a pseudo second-order model (R-2 = 0.9981), indicating chemisorption as the rate-limiting mechanism. Thermodynamic parameters (Delta H degrees = 6.61 kJ/mol, Delta G degrees < 0) confirmed that the process was endothermic and spontaneous. These findings demonstrate that RHAC is a highly efficient, low-cost, and sustainable adsorbent for removing ciprofloxacin from aqueous environments.Article Citation - WoS: 34Citation - Scopus: 38Magnetic diatomite for pesticide removal from aqueous solution via hydrophobic interactions(Springer Link, 2019) Erol, Kadir; Yıldız, Emrecan; Alacabey, İhsan; Karabörk, Muharrem; Uzun, LokmanPesticides are highly hazardous chemicals for the environment and human health and their use in agriculture is constantly increasing. Although 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane 4,4′-DDT was banned at developed countries, it is still one of the most dangerous of chemical due to accumulation in the environment. It is known that the toxicity of DDT affects some enzyme systems biochemically. The main motivation of this study is to develop an effective adsorbate for the removal DDT, which was chosen as a model hydrophobic pesticide, out of aqueous systems. For this purpose, the bare diatomite particles were magnetically modified and a hydrophobic ligand attached to enhance its adsorptive and physio-chemical features. Under optimal conditions, a high adsorption capacity, around 120 mg/g with the hydrophobic and magnetic diatomite particles, modification of the diatomite particles reduced average pores diameter whereas surface area and total pore volume increased (around 15-folds). After five consecutive adsorption–desorption cycles, no significant decrease in adsorption capability was observed. The adsorption isotherms (Langmuir, Freundlich, and Flory–Huggins) applied to the data indicated that the adsorption process occurred via monolayer adsorption in an entropy-driven manner. The kinetic data also revealed the quick adsorption process without any diffusion limitationsArticle Citation - WoS: 10Citation - Scopus: 11Endosulfan Elimination Using Amine-Modified Magnetic Diatomite as an Adsorbent(Frontiers in Chemistry, 2022) Alacabey, İhsanPesticides are among the most dangerous developing toxins since they are very hazardous to the environment and threaten human health. In this study, researchers successfully manufactured surface-modified magnetic diatomite (m-DE-APTES) and used them as a sorbent to extract endosulfan from an aqueous solution. There is no other study like it in the scholarly literature, and the results are astounding. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray (EDX), electron spin resonance (ESR), and surface area measurements were used to analyze magnetic diatomite particles with surface modification. According to the analysis results, magnetic diatomite has a wide surface area and a porous structure. Furthermore, m-DE-APTES has a higher endosulfan adsorption capacity (97.2 mg g-1) than raw diatomite (DE) (16.6 mg g-1). Adsorption statistics agree with Langmuir adsorption isotherm (R 2 = 0.9905), and the adsorption occurred spontaneously at -2.576 kj mol-1 in terms of ΔGo. Finally, m-DE-APTES are a viable alternative adsorbent for removing pesticides from aqueous solutions.Article Preconcentration and Determination of Cu(ii) and Cd(ii) Ions From Wastewaters by Using Hazelnut Shell Biosorbent Immobilized on Amberlite Xad-4 Resin(2023) Alacabey, İhsan; Erol, Kadir; Teğin, İbrahim; Akdeniz, Selma; Acar, OrhanHazelnut shell biosorbent immobilized on Amberlite XAD-4 polymer resin as solid phase extraction method was developed and used for preconcentration of Cu(II) and Cd(II) ions from aqueous solutions. Concentrations of analytes in solutions were determined by Flame Atomic Absorption Spectrometry after extraction with column technique. Functional groups of nutshell biosorbent immobilized on resin were characterized by Fourier transform infrared spectrometry. Optimized critical parameters for preconcentration of Cu2+ and Cd2+ ions from sample solutions with nutshell immobilized on the resin were the pH value of solution, type of eluent solutions, the flow rate of sample solution, quantities of nutshell biosorbent, Amberlite XAD-4 resin, and enrichment factors, respectively. Detection limits of Cu2+ and Cd2+ ions found were 0.29 μg L-1 and 0.25 μg L-1, respectively. The method proposed was applied for determinations of Cu2+ and Cd2+ ions in standard reference material (BCR-670 aquatic plant sample) for accuracy and applied to real water samples such as wastewater and Van lake water. At the 95% confidence level, relative standard deviations (RSDs) were found as 1.44% for Cd2+ and 1.21% for Cu2+ ions with three replicate measurements.Article Citation - WoS: 25Citation - Scopus: 32Antibiotic Removal from the Aquatic Environment with Activated Carbon Produced from Pumpkin Seeds(Molecules, 2022) Alacabey, İhsanAntibiotics are among the most critical environmental pollutant drug groups. Adsorption is one of the methods used to eliminate these pollutants. In this study, activated carbon was produced from pumpkin seed shells and subsequently modified with KOH. The adsorbent obtained through this procedure was used to remove ciprofloxacin from aqueous systems. Fourier Transform-Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), elemental, X-ray Photoelectron Spectroscopy (XPS), Brunauer–Emmett–Teller (BET) and Zeta analyses were used to characterize the adsorbent. The surface area, in particular, was found to be a very remarkable value of 2730 m2/g. The conditions of the adsorption experiments were optimized based on interaction time, adsorbent amount, pH and temperature. Over 99% success was achieved in removal operations carried out under the most optimal conditions, with an absorption capacity of 884.9 mg·g−1. In addition, the Langmuir isotherm was determined to be the most suitable model for the adsorption interactionMaster Thesis Bıttım ve Menengiç Bitkilerinden Elde Edilen Aktif Karbon ile Sulu Çözeltilerden Karbofuran Giderimi(2024) Açil, Hüsnü; Alacabey, İhsanPestisitler, gıda üretim ve verimini artırmak için tarım alanında yaygın olarak kullanılmaktadır, ancak yaygın kullanımı büyük çevresel kirlenmelere sebep olmaktadır. Tarım alanında pestisitlerin uzun zaman ve sürekli uygulanması, zararlı böcek, bakteri ve haşerelerin bu ilaçlara karşı dirençlerinin artmasına neden olmakta, bundan dolayı bir önceki yıla göre daha fazla miktarda pestisit kullanımı gerçekleşmektedir. Karbofuran kimyasal özellikleri kapsamında sistematik etkili intektisit, akarisit ve nematositler arasında bulunan en toksik karbamatlı birleşiktir. Son zamanlarda özellikle biyoteknoloji alanında ideal malzemelerin geliştirilmesinin gerekliliğinden dolayı Mardin ilinde yetişen Bıttım ve Siirt ilinde yetişen Menengiç bitkilerinden Potasyum hidroksit aktivasyonu ile aktif karbon üretilmiştir. Bu çalışmada, sulu çözeltiden karbofuranın uzaklaştırılması için adsorbent olarak aktif karbon batch adsorpsiyon yöntemiyle incelenmiştir. Optimum adsorpsiyon koşullarını bulmak için pH, adsorbent dozu, temas süresi, konsantrasyon etkisi araştırıldı. Langmuir, Freundlich ve Dubinin–Radushkevich (D–R) ve Temkin adsorpsiyon izoterm denklemleri uygulandı. Her iki adsorbent için Langmuir adsorpsiyon izotermine uyduğu bulunmuştur. Adsorpsiyonun tek tabakalı ve homojen olduğunu göstermektedir. Langmuir adsorpsiyon izoterm çalışmalarında Menengiç Aktif Karbonu için qmax 344.9 mg/g ve Bıttım aktif karbonu için qmax 380.4 mg/g adsorpsiyon kapasitesine sahip olduğu hesaplanmıştır. Dubinin-Radushkevich (D-R) modelinde E değeri < 8 kJ/mol olduğu hesaplanmıştır, bu da adsorpsiyon prosesinin fiziksel olarak gerçekleştiğini göstermektedir. Entalpi (ΔH0), Gibbs'in serbest enerjisi (ΔG0) ve entropi (ΔS0) gibi termodinamik parametreler hesaplandı. ΔG0 değerlerinin negatif çıkması hem Bıttım aktif karbonu hem de Menengiç aktif karbonu üzerindeki karbofuran adsorpsiyonun kendiliğinden gerçekleştiği göstermektedir. Her iki adsorbentin ΔH0 değerlerinin negatif olması prosesin ekzotermik olduğunu göstermektedir. Negatif ∆S0 değeri, karbofuran moleküllerinin, adsorbent yüzeyindeki adsorpsiyon sırasında katı/çözelti arayüzünde düzensizliğin azaldığı veya artan düzenlilik sergilediğini ve adsorpsiyon prosesinin, adsorban yüzeyindeki yeniden düzenlemeyi desteklediğini gösterir. Bıttım ve Menengiç bitkilerinden elde edilen aktif karbon ile sulu çözeltilerden karbofuran adsorpsiyon prosesinin ekzotermik olduğu, tek tabakada ve üniform olarak fiziksel mekanizma ile kendiliğinden gerçekleştiğini göstermiştir.Article Citation - WoS: 57Citation - Scopus: 58O-carboxymethyl chitosan Schiff base complexes as affinity ligands for immobilized metal-ion affinity chromatography of lysozyme(ELSEVIER SCIENCE BV, 2018) Acet, Ömür; Baran, Talat; Erdönmez, Demet; Aksoy, Neşe Hayat; Alacabey, İhsan; Menteş, Ayfer; Odabaşı, MehmetWe synthesized Ni2+-attached O-Carboxymethyl chitosan Schiff base complexes embedded composite cryogels (Ni2+-O-CMCS-CCs) by means of polymerization of gel-forming precursors at subzero temperatures. Prepared affinity cryogel showed excellent adsorption performance for lysozyme selected as model protein to test adsorption parameters, demonstrating an adsorption capacity of 244.6 mg/g (15.3 mg/g for Ni2+ minus O-CMCS-CCs), with fast adsorption equilibrium within 30 min and good reversibility. The performance of Ni2+-O-CMCS-CCs for lysozyme was also evaluated by SDS-PAGE, and a purification efficiency of 86.9% with 89.5% purification yield was determined. The swelling test, FT-IR, and SEM analysis were carried out for the characterization of Ni2+-O-CMCS-CCs. At the end of 35 adsorption-desorption cycles, there was no significant change in the adsorption capacity. (C) 2018 Elsevier B.V. All rights reserved.
