Effects of acute carbon monoxide posioning on liver damage and comparisons of related oxygen therapies in a rat model

dc.contributor.author Demirtas, Berjan
dc.contributor.author Taskin, Seyhan
dc.contributor.author Gokdemir, Gul Sahika
dc.contributor.author Seker, Ugur
dc.date.accessioned 2024-05-17T11:58:49Z
dc.date.accessioned 2025-09-17T14:28:26Z
dc.date.available 2024-05-17T11:58:49Z
dc.date.available 2025-09-17T14:28:26Z
dc.date.issued 2024
dc.description Demirtas, Berjan/0000-0002-0371-6376; Seker, Ugur/0000-0002-1693-6378; Gokdemir, Gul Sahika/0000-0002-8691-1504 en_US
dc.description.abstract Acute carbon monoxide (CO) poisoning may cause liver damage and liver dysfunction. Therefore, in this study, we aimed to compare the efficiency of normobaric oxygen (NBO) and high-flow nasal cannula oxygen (HFNCO) treatments on liver injury. For that purpose, 28 male Wistar albino rats were divided into four groups (Control, CO, CO + NBO, and CO + HFNCO). The control group was allowed to breath room air for 30 min. Acute CO poisoning in CO, CO + NBO, CO + HFNCO was induced by CO exposure for 30 min. Thereafter, NBO group received 100% NBO with reservoir mask for 30 min. HFNCO group received high-flow oxygen through nasal cannula for 30 min. At the end of the experiment, all animals were sacrificed by cardiac puncture under anesthesia. Serum liver function tests were measured. Liver tissue total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels, tissue histomorphology and immunoexpression levels of Bax, Caspase 3, TNF-alpha, IL-1 beta, and NF-kappa B were also examined. Our observations indicated that acute CO poisoning caused significant increases in blood COHb, serum aminotransferase (AST), alanine aminotransferase (ALT0, alkaline phosphatase (ALP), total protein, albumin, and globulin levels but a decrease in albumin to globulin ratio (all, p < 0.05). Furthermore, acute CO poisoning significantly increased the OSI value, and the immunoexpresssion of Bax, Caspase 3, TNF-alpha, IL-1 beta, and NF-kappa B in liver tissue (all, p < 0.05). These pathological changes in serum and liver tissue were alleviated through both of the treatment methods. In conclusion, both the NBO and HFNCO treatments were beneficial to alleviate the acute CO poisoning associated with liver injury and dysfunction. [GRAPHICS] . en_US
dc.identifier.citation Gokdemir, G., Seker, U., Demirtas, B., & Taskin, S. (2024). Effects of acute carbon monoxide posioning on liver damage and comparisons of related oxygen therapies in a rat model. Toxicology Mechanisms and Methods, 1–16. https://doi.org/10.1080/15376516.2024.2353887 en_US
dc.identifier.doi 10.1080/15376516.2024.2353887
dc.identifier.issn 1537-6516
dc.identifier.issn 1537-6524
dc.identifier.scopus 2-s2.0-85193947301
dc.identifier.uri https://doi.org/10.1080/15376516.2024.2353887
dc.identifier.uri https://hdl.handle.net/20.500.12514/9620
dc.language.iso en en_US
dc.publisher Taylor & Francis Ltd en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Imath en_US
dc.subject Nflammation en_US
dc.subject Nf-Kappa B en_US
dc.subject Normabaric en_US
dc.subject High-Flow Nasal Canule en_US
dc.subject Male Rats en_US
dc.subject Apoptosis en_US
dc.subject Carbon Monoxide en_US
dc.subject Liver Toxicity en_US
dc.title Effects of acute carbon monoxide posioning on liver damage and comparisons of related oxygen therapies in a rat model
dc.title Effects of Acute Carbon Monoxide Poisoning on Liver Damage and Comparisons of Related Oxygen Therapies in a Rat Model en_US
dc.type Article en_US
dspace.entity.type Publication

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