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Regulation of Stat3 and Nf-Κb Signaling Pathways By Trans-anethole in Testicular Ischemia-Reperfusion Injury and Its Gonadoprotective Effect

dc.authorscopusid55910059600
dc.authorscopusid55943383300
dc.authorscopusid55360150900
dc.authorscopusid7006176088
dc.authorscopusid57702190200
dc.authorscopusid57195241381
dc.authorwosidKati, Bulent/AGQ-3954-2022
dc.authorwosidYüksel, Meral/Z-3692-2019
dc.authorwosidShokoohi, Majid/J-7219-2019
dc.authorwosidSeker, Ugur/A-7403-2014
dc.authorwosidGökçe, Yasin/AAJ-7901-2021
dc.contributor.authorSeker, Ugur
dc.contributor.authorGokce, Yasin
dc.contributor.authorKati, Bulent
dc.contributor.authorYuksel, Meral
dc.contributor.authorGuzel, Baris Can
dc.contributor.authorShokoohi, Majid
dc.date.accessioned2025-02-15T19:35:48Z
dc.date.available2025-02-15T19:35:48Z
dc.date.issued2024
dc.departmentArtuklu Universityen_US
dc.department-temp[Seker, Ugur] Mardin Artuklu Univ, Fac Med, Dept Histol & Embryol, TR-47200 Mardin, Turkiye; [Gokce, Yasin] Harran Univ, Fac Med, Dept Biophys, TR-63050 Sanliurfa, Turkiye; [Kati, Bulent] Harran Univ, Fac Med, Dept Urol, TR-63050 Sanliurfa, Turkiye; [Yuksel, Meral] Marmara Univ, Vocat Sch Hlth Related Profess, Dept Med Lab, TR-34865 Istanbul, Turkiye; [Guzel, Baris Can] Siirt Univ, Fac Vet Med, Dept Vet Anat, TR-56100 Siirt, Turkiye; [Shokoohi, Majid] Tabriz Univ Med Sci, Clin Res Dev Unit, Tabriz Valiasr Hosp, Tabriz 5165687386, Iranen_US
dc.description.abstractTesticular ischemia reperfusion (I/R) injury is a significant urological problem where clinical interventions may be inadequate, and the antioxidants might be potential co-treatment modalities. This study examined the gonadoprotective effect of trans-Anethole in testicular I/R injury. Twenty-eight male rats were divided into four groups. Rats in the I/R, I/R + t100, I/R + t200 groups underwent bilateral testicular I/R injury. The I/R + t100 and I/R + t200 groups received 100 or 200 mg/kg trans-Anethole at the 2nd hour of ischemia. Microscopic evaluations demonstrated that testicular I/R injury leads to severe testicular degeneration. Tissue oxidative stress, pro-apoptotic Bcl-2 associated X (Bax) and Caspase 3, pro-inflammatory Tumor necrosis factor-alpha (TNF-alpha), Interleukin-1 beta (IL-1 beta) and Interleukin 6 (IL-6) cytokines levels were significantly (p < 0.05) upregulated when compared to the Control group. Additionally, transcription factors Signal transducer and activator of transcription 3 (STAT3) and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) levels increased significantly (p < 0.05) compared to the Control group. Tissue disrupted parameters in the I/R + t200 group were significantly different (p < 0.05) from the I/R group, contrasting with the slight improvement in the I/R + t100 group. The STAT3 and NF-kappa B expression levels in the I/R + t200 group were significantly suppressed (p < 0.05) compared to the I/R group. In conclusion, our study indicates that trans-Anethole could enhance gonadoprotective activity in testicular I/R injury, potentially involving transcription factors STAT3 and NF-kappa B. However, before the consumption of trans-Anethole-containing natural or manufactured goods, the potential benefits and side effects should be carefully evaluated.en_US
dc.description.woscitationindexScience Citation Index Expanded
dc.identifier.citationcount0
dc.identifier.doi10.22514/j.androl.2024.015
dc.identifier.endpage67en_US
dc.identifier.issn1698-031X
dc.identifier.issue3en_US
dc.identifier.pmid39394750
dc.identifier.scopus2-s2.0-85206123282
dc.identifier.scopusqualityQ3
dc.identifier.startpage57en_US
dc.identifier.urihttps://doi.org/10.22514/j.androl.2024.015
dc.identifier.urihttps://hdl.handle.net/20.500.12514/6063
dc.identifier.volume22en_US
dc.identifier.wosWOS:001394837300008
dc.identifier.wosqualityQ4
dc.language.isoenen_US
dc.publisherMre Pressen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTestisen_US
dc.subjectIschemia Reperfusion Injuryen_US
dc.subjectTrans-Anetholeen_US
dc.subjectApoptosisen_US
dc.subjectInflammationen_US
dc.titleRegulation of Stat3 and Nf-Κb Signaling Pathways By Trans-anethole in Testicular Ischemia-Reperfusion Injury and Its Gonadoprotective Effecten_US
dc.typeArticleen_US
dspace.entity.typePublication

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