Regulation of Stat3 and Nf-Κb Signaling Pathways By Trans-anethole in Testicular Ischemia-Reperfusion Injury and Its Gonadoprotective Effect

dc.contributor.author Şeker, Uğur
dc.contributor.author Gokce, Yasin
dc.contributor.author Kati, Bulent
dc.contributor.author Yuksel, Meral
dc.contributor.author Guzel, Baris Can
dc.contributor.author Shokoohi, Majid
dc.contributor.other Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
dc.contributor.other 10. Faculty of Medicine / Tıp Fakültesi
dc.contributor.other 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
dc.date.accessioned 2025-02-15T19:35:48Z
dc.date.available 2025-02-15T19:35:48Z
dc.date.issued 2024
dc.description.abstract Testicular ischemia reperfusion (I/R) injury is a significant urological problem where clinical interventions may be inadequate, and the antioxidants might be potential co-treatment modalities. This study examined the gonadoprotective effect of trans-Anethole in testicular I/R injury. Twenty-eight male rats were divided into four groups. Rats in the I/R, I/R + t100, I/R + t200 groups underwent bilateral testicular I/R injury. The I/R + t100 and I/R + t200 groups received 100 or 200 mg/kg trans-Anethole at the 2nd hour of ischemia. Microscopic evaluations demonstrated that testicular I/R injury leads to severe testicular degeneration. Tissue oxidative stress, pro-apoptotic Bcl-2 associated X (Bax) and Caspase 3, pro-inflammatory Tumor necrosis factor-alpha (TNF-alpha), Interleukin-1 beta (IL-1 beta) and Interleukin 6 (IL-6) cytokines levels were significantly (p < 0.05) upregulated when compared to the Control group. Additionally, transcription factors Signal transducer and activator of transcription 3 (STAT3) and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) levels increased significantly (p < 0.05) compared to the Control group. Tissue disrupted parameters in the I/R + t200 group were significantly different (p < 0.05) from the I/R group, contrasting with the slight improvement in the I/R + t100 group. The STAT3 and NF-kappa B expression levels in the I/R + t200 group were significantly suppressed (p < 0.05) compared to the I/R group. In conclusion, our study indicates that trans-Anethole could enhance gonadoprotective activity in testicular I/R injury, potentially involving transcription factors STAT3 and NF-kappa B. However, before the consumption of trans-Anethole-containing natural or manufactured goods, the potential benefits and side effects should be carefully evaluated. en_US
dc.identifier.citationcount 0
dc.identifier.doi 10.22514/j.androl.2024.015
dc.identifier.issn 1698-031X
dc.identifier.scopus 2-s2.0-85206123282
dc.identifier.uri https://doi.org/10.22514/j.androl.2024.015
dc.identifier.uri https://hdl.handle.net/20.500.12514/6063
dc.language.iso en en_US
dc.publisher Mre Press en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Testis en_US
dc.subject Ischemia Reperfusion Injury en_US
dc.subject Trans-Anethole en_US
dc.subject Apoptosis en_US
dc.subject Inflammation en_US
dc.title Regulation of Stat3 and Nf-Κb Signaling Pathways By Trans-anethole in Testicular Ischemia-Reperfusion Injury and Its Gonadoprotective Effect en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.scopusid 55910059600
gdc.author.scopusid 55943383300
gdc.author.scopusid 55360150900
gdc.author.scopusid 7006176088
gdc.author.scopusid 57702190200
gdc.author.scopusid 57195241381
gdc.author.wosid Kati, Bulent/AGQ-3954-2022
gdc.author.wosid Yüksel, Meral/Z-3692-2019
gdc.author.wosid Shokoohi, Majid/J-7219-2019
gdc.author.wosid Seker, Ugur/A-7403-2014
gdc.author.wosid Gökçe, Yasin/AAJ-7901-2021
gdc.description.department Artuklu University en_US
gdc.description.departmenttemp [Seker, Ugur] Mardin Artuklu Univ, Fac Med, Dept Histol & Embryol, TR-47200 Mardin, Turkiye; [Gokce, Yasin] Harran Univ, Fac Med, Dept Biophys, TR-63050 Sanliurfa, Turkiye; [Kati, Bulent] Harran Univ, Fac Med, Dept Urol, TR-63050 Sanliurfa, Turkiye; [Yuksel, Meral] Marmara Univ, Vocat Sch Hlth Related Profess, Dept Med Lab, TR-34865 Istanbul, Turkiye; [Guzel, Baris Can] Siirt Univ, Fac Vet Med, Dept Vet Anat, TR-56100 Siirt, Turkiye; [Shokoohi, Majid] Tabriz Univ Med Sci, Clin Res Dev Unit, Tabriz Valiasr Hosp, Tabriz 5165687386, Iran en_US
gdc.description.endpage 67 en_US
gdc.description.issue 3 en_US
gdc.description.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
gdc.description.scopusquality Q3
gdc.description.startpage 57 en_US
gdc.description.volume 22 en_US
gdc.description.woscitationindex Science Citation Index Expanded
gdc.description.wosquality Q4
gdc.identifier.pmid 39394750
gdc.identifier.wos WOS:001394837300008
gdc.scopus.citedcount 8
gdc.wos.citedcount 7
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