Regulation of Stat3 and Nf-Κb Signaling Pathways By Trans-anethole in Testicular Ischemia-Reperfusion Injury and Its Gonadoprotective Effect
dc.authorscopusid | 55910059600 | |
dc.authorscopusid | 55943383300 | |
dc.authorscopusid | 55360150900 | |
dc.authorscopusid | 7006176088 | |
dc.authorscopusid | 57702190200 | |
dc.authorscopusid | 57195241381 | |
dc.authorwosid | Kati, Bulent/AGQ-3954-2022 | |
dc.authorwosid | Yüksel, Meral/Z-3692-2019 | |
dc.authorwosid | Shokoohi, Majid/J-7219-2019 | |
dc.authorwosid | Seker, Ugur/A-7403-2014 | |
dc.authorwosid | Gökçe, Yasin/AAJ-7901-2021 | |
dc.contributor.author | Seker, Ugur | |
dc.contributor.author | Gokce, Yasin | |
dc.contributor.author | Kati, Bulent | |
dc.contributor.author | Yuksel, Meral | |
dc.contributor.author | Guzel, Baris Can | |
dc.contributor.author | Shokoohi, Majid | |
dc.date.accessioned | 2025-02-15T19:35:48Z | |
dc.date.available | 2025-02-15T19:35:48Z | |
dc.date.issued | 2024 | |
dc.department | Artuklu University | en_US |
dc.department-temp | [Seker, Ugur] Mardin Artuklu Univ, Fac Med, Dept Histol & Embryol, TR-47200 Mardin, Turkiye; [Gokce, Yasin] Harran Univ, Fac Med, Dept Biophys, TR-63050 Sanliurfa, Turkiye; [Kati, Bulent] Harran Univ, Fac Med, Dept Urol, TR-63050 Sanliurfa, Turkiye; [Yuksel, Meral] Marmara Univ, Vocat Sch Hlth Related Profess, Dept Med Lab, TR-34865 Istanbul, Turkiye; [Guzel, Baris Can] Siirt Univ, Fac Vet Med, Dept Vet Anat, TR-56100 Siirt, Turkiye; [Shokoohi, Majid] Tabriz Univ Med Sci, Clin Res Dev Unit, Tabriz Valiasr Hosp, Tabriz 5165687386, Iran | en_US |
dc.description.abstract | Testicular ischemia reperfusion (I/R) injury is a significant urological problem where clinical interventions may be inadequate, and the antioxidants might be potential co-treatment modalities. This study examined the gonadoprotective effect of trans-Anethole in testicular I/R injury. Twenty-eight male rats were divided into four groups. Rats in the I/R, I/R + t100, I/R + t200 groups underwent bilateral testicular I/R injury. The I/R + t100 and I/R + t200 groups received 100 or 200 mg/kg trans-Anethole at the 2nd hour of ischemia. Microscopic evaluations demonstrated that testicular I/R injury leads to severe testicular degeneration. Tissue oxidative stress, pro-apoptotic Bcl-2 associated X (Bax) and Caspase 3, pro-inflammatory Tumor necrosis factor-alpha (TNF-alpha), Interleukin-1 beta (IL-1 beta) and Interleukin 6 (IL-6) cytokines levels were significantly (p < 0.05) upregulated when compared to the Control group. Additionally, transcription factors Signal transducer and activator of transcription 3 (STAT3) and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) levels increased significantly (p < 0.05) compared to the Control group. Tissue disrupted parameters in the I/R + t200 group were significantly different (p < 0.05) from the I/R group, contrasting with the slight improvement in the I/R + t100 group. The STAT3 and NF-kappa B expression levels in the I/R + t200 group were significantly suppressed (p < 0.05) compared to the I/R group. In conclusion, our study indicates that trans-Anethole could enhance gonadoprotective activity in testicular I/R injury, potentially involving transcription factors STAT3 and NF-kappa B. However, before the consumption of trans-Anethole-containing natural or manufactured goods, the potential benefits and side effects should be carefully evaluated. | en_US |
dc.description.woscitationindex | Science Citation Index Expanded | |
dc.identifier.citationcount | 0 | |
dc.identifier.doi | 10.22514/j.androl.2024.015 | |
dc.identifier.endpage | 67 | en_US |
dc.identifier.issn | 1698-031X | |
dc.identifier.issue | 3 | en_US |
dc.identifier.pmid | 39394750 | |
dc.identifier.scopus | 2-s2.0-85206123282 | |
dc.identifier.scopusquality | Q3 | |
dc.identifier.startpage | 57 | en_US |
dc.identifier.uri | https://doi.org/10.22514/j.androl.2024.015 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12514/6063 | |
dc.identifier.volume | 22 | en_US |
dc.identifier.wos | WOS:001394837300008 | |
dc.identifier.wosquality | Q4 | |
dc.language.iso | en | en_US |
dc.publisher | Mre Press | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Testis | en_US |
dc.subject | Ischemia Reperfusion Injury | en_US |
dc.subject | Trans-Anethole | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Inflammation | en_US |
dc.title | Regulation of Stat3 and Nf-Κb Signaling Pathways By Trans-anethole in Testicular Ischemia-Reperfusion Injury and Its Gonadoprotective Effect | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication |