Hyaluronic Acid as a New Biomarker To Differentiate Acute Kidney Injury From Chronic Kidney Disease

dc.contributor.author Akin, Davut
dc.contributor.author Özmen, Şehmus
dc.contributor.author Ozmen, Sehmus
dc.contributor.author Yilmaz, Mehmet Emin
dc.contributor.other 09.01. Department of Nursing / Hemşirelik Bölümü
dc.contributor.other 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi
dc.contributor.other 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
dc.date.accessioned 2025-09-18T11:51:52Z
dc.date.available 2025-09-18T11:51:52Z
dc.date.issued 2017
dc.description Akin, Davut/0000-0002-9567-7940 en_US
dc.description.abstract Introduction. It may be difficult to differentiate acute kidney injury from chronic kidney disease in patients with no past medical reports of kidney function. This study aimed to investigate the role of serum hyaluronic acid (HA), which is known as a marker of fibrosis, in differential diagnosis of kidney failure. Materials and Methods. A total of 90 patients (52 women and 38 mne) admitted to our renal unit with uremia for the first time were included. Serum HA level was measured. The diagnostic role of the test was investigated using the receiver operator curve curves. Results. The mean age of the patients was 54.6 +/- 17.9 years. The diagnosis was chronic kidney disease (CKD) in 41.1%, acute kidney injury (AKI) in 48.9%, AKI on CKD in 6.7% (3 died without a diagnosis). The mean serum HA was significantly higher in the CKD group (146.1 +/- 119.3 ng/mL) than the AKI group (68.9 +/- 69.1 ng/mL; P < .001). Serum HA significantly correlated with proteinuria (r = 0.717, P < .001) and serum albumin level (r = -0.599, P < .001) in the CKD group only. Serum HA cutoff level of 61 ng/dL had a sensitivity of 82% and specificity of 67% for differential diagnosis of AKI and CKD. Conclusions. Serum HA level may be used as tool to differentiate AKI from CKD. Further larger studies are warranted to clarify the definite the role of this marker. en_US
dc.identifier.citationcount 21
dc.identifier.issn 1735-8582
dc.identifier.issn 1735-8604
dc.identifier.scopus 2-s2.0-85036647483
dc.identifier.uri https://hdl.handle.net/20.500.12514/9754
dc.language.iso en en_US
dc.publisher Iranian Soc Nephrolgy en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Hyaluronic Acid en_US
dc.subject Chronic Kidney Disease en_US
dc.subject Acute Kidney Injury en_US
dc.title Hyaluronic Acid as a New Biomarker To Differentiate Acute Kidney Injury From Chronic Kidney Disease en_US
dc.type Article en_US
dspace.entity.type Publication
gdc.author.id Akin, Davut/0000-0002-9567-7940
gdc.author.wosid Sehmus Ozmen/Lwz-9828-2024
gdc.author.wosid Akin, Davut/Aac-3137-2020
gdc.coar.access metadata only access
gdc.coar.type text
gdc.description.department Artuklu University en_US
gdc.description.departmenttemp [Akin, Davut] Denizli State Hosp, Clin Nephrol, TR-20010 Denizli, Turkey; [Ozmen, Sehmus] Mardin Artuklu Univ, Sch Hlth, Mardin, Turkey; [Ozmen, Sehmus] Diyarbakir Training Hosp, Div Nephrol, Diyarbakir, Turkey; [Yilmaz, Mehmet Emin] Dicle Univ, Sch Med, Div Nephrol, Diyarbakir, Turkey en_US
gdc.description.endpage 413 en_US
gdc.description.issue 6 en_US
gdc.description.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
gdc.description.scopusquality Q3
gdc.description.startpage 409 en_US
gdc.description.volume 11 en_US
gdc.description.woscitationindex Science Citation Index Expanded
gdc.description.wosquality Q4
gdc.identifier.pmid 29190600
gdc.identifier.wos WOS:000417093300003
gdc.scopus.citedcount 21
gdc.wos.citedcount 19

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