WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3595

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Evaluation of the Neurodevelopmental Status for Urea Cycle Disorders: Based on Clinical Experience
(Galenos Publ House, 2023) Bozaci, Ayse Ergul; Goksoy, Emine; Unal, Aysel Tekmenuray; Albayrak, Hatice Mutlu; Tas, Ibrahim; Kanar, Berat; Kose, Melis
Aim: Urea cycle disorders (UCD) still have poor neurological outcomes despite early diagnosis and treatment. We aimed to present the neurological outcomes of UCD patients and to determine the main simple and accessible factors affecting these outcomes. Materials and Metkods: This was a descriptive cross-sectional study conducted in two pediatric metabolism centers on 29 patients from 25 unrelated families who were diagnosed and followed with UCD based on clinical presentation, neurological parameters, biochemical measurements, and molecular analysis.Results: Within the study population, the most common diagnosis was argininosuccinate synthase deficiency in 13 (44.82%) patients, followed by N-acetylglutamate synthase deficiency in five patients (17.24%), ornithine transcarbamylase deficiency in four patients (13.79%), arginase 1 deficiency in three patients (10.34%), carbamoyl phosphate synthase 1 deficiency in three patients (10.34%), and argininosuccinate lyase deficiency in one patient (3.44%). Peak ammonia levels were observed to be significantly higher in those patients with delayed milestones and patients who had Denver II <-2 standard deviation score results (p=0.032, p=0.026). Effect sizes were large in both groups. Delayed milestones were noted in 17 (94.4%) of the cases with peak ammonia >500 mu mol/L (n=18). Those patients with abnormal neurological parameters had a significantly higher mean number of hyperammonemic episodes per year. Extracorporeal detoxification was given to eight patients, in combination with therapeutic hypothermia in two patients. Rapid regression was observed in brain edema in those who underwent therapeutic hypothermia.Conclusion: Our study emphasizes the effect of peak ammonia levels and the frequency of hyperammonemic episodes on neurological outcomes. There were still poor neurocognitive outcomes despite extracorporeal detoxification. This highlights the need to reassess current treatment strategies, including the threshold for starting extracorporeal detoxification if ammonia levels exceed 500 mu mol/L. The use of therapeutic hypothermia by experienced teams may be promising due to its brain edema-reducing effects.
The Potential Renoprotective Effect of Sugammadex in Renal Ischemia-Reperfusion Injury
(Galenos Publ House, 2025) Kolukcu, Vildan; Bala, Mehtap Gurler; Sahin, Ahmet Tugrul; Genc, Ali; Unsal, Velid; Firat, Fatih; Gurpinar, Ahmer Burak
Objective: We aimed to evaluate the effectiveness of sugammadex on renal tissue for against ischemia-reperfusion injury. Methods: Twenty-one Wistar albino strain female rats were divided into three groups. The first group functioned as the control cohort for comparison. In Groups 2 and 3, a renal ischemia-reperfusion model was established. Moreover, following the cessation of ischemia, the rats in Group 3 were intravenously administered sugammadex at a dose of 4 mg kg-1. Blood and tissue samples were subsequently collected for analysis. Results: Biochemical analyses revealed a notable increase in the enzymatic activities of glutathione peroxidase and superoxide dismutase in Group 3 relative to Group 2 (P < 0.001 and P=0.015, respectively). Additionally, the concentration of malondialdehyde was found to be significantly reduced in Group 3 relative to Group 2 (P=0.004). Group 3 exhibited a substantial decrease in tumor necrosis factor-alpha, interleukin 6, and interleukin 1 beta levels when compared to Group 2 (P=0.021, P=0.006, and P=0.016 respectively). Group 2 exhibited the highest concentrations of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 (P < 0.001 and P=0.015, respectively). Similarly, the histopathologic tissue damage was the most prominent in Group 2 (P < 0.001). Conclusion: Sugammadex plays a protective role against ischaemia-reperfusion injury in renal tissue.
Sectarian Diplomacy and the Transformation of Ottoman Statecraft: Yâsincizâde Abdülvehhâb Efendi's Embassy to Qajar Iran (1810-1813)
(MDPI, 2025) Tan, Hasan
At the beginning of the 19th century, Ottoman-Iranian relations entered a new diplomatic phase shaped by Russia's expansion in the Caucasus and Britain's growing influence in the Persian Gulf. This shared perception of external threats led to the establishment of a more structured and representative diplomatic framework between the two empires. This study examines the embassy of Y & acirc;sinciz & acirc;de Abd & uuml;lvehh & acirc;b Efendi, who was appointed as Ottoman ambassador to Iran between 1810 and 1813, in the context of a shifting diplomatic mindset. Y & acirc;sinciz & acirc;de's mission is analyzed not merely as a temporary diplomatic engagement, but as a form of ideological, sectarian, and cultural representation by a figure from the ulema class. Based on archival sources, the study reveals that his diplomatic reports and observations provided critical input to the central administration, contributing to the development of more institutionalized and long-term strategies in Ottoman policy toward Iran. By focusing on the transitional character of his embassy, the paper reassesses the evolving role of religious scholars in Ottoman foreign relations and situates this case between the classical sefaretn & acirc;me tradition and emerging modern diplomatic practices.
The Relationship Between Mothers' Optimism and Children's Anxiety: The Mediating Role of Mothers' Psychological Resilience
(Springer, 2025) Polat, Pinar
This study aimed to investigate the relationships between mothers' optimism, psychological resilience, and children's anxiety, focusing on the mediating role of psychological resilience in T & uuml;rkiye. Using a cross-sectional design, data were collected from 394 mothers with children aged 4-6 through an online survey. Confirmatory factor analysis and structural equation modeling were used to analyze the data. The findings indicated a positive association between mothers' optimism and psychological resilience, and a negative association between psychological resilience and children's anxiety levels. Moreover, psychological resilience served as a mediator, indicating that mothers' optimism indirectly reduced children's anxiety by increasing psychological resilience. These findings highlight the protective role of maternal resilience in reducing children's anxiety and suggest that interventions aimed at strengthening mothers' resilience may contribute to improving children's emotional well-being.
Citation - WoS: 2
Citation - Scopus: 2
Roles of Loneliness and Life Satisfaction in the Relationship Between Perceived Friend Social Support, Positive Feelings About the Future and Loss of Motivation
(Elsevier, 2025) Aslan, Yavuz; Kocak, Orhan; Kaya, Aysel Basmaci; Alkhulayfi, Abdulmohsen Mohammed Abdullah; Gomez Salgado, Juan; Yildirim, Murat
Purpose: University students often face psychological challenges, particularly loneliness and hopelessness, which are exacerbated by factors such as limited social interactions, economic uncertainty, lack of employment opportunities, and the increasing prevalence of online education. This study aims to investigate the relationships among perceived friend social support, loneliness, life satisfaction, and the sub-dimensions of hopelessness, which are positive feelings about the future and loss of motivation. Design/methodology/approach: This cross-sectional quantitative study was conducted with 420 university students who completed a series of self-reported measures, including the Multidimensional Perceived Social Support Scale, the UCLA Loneliness Scale, the Satisfaction with Life Scale, and the Beck Hopelessness Scale. Findings: The findings revealed that perceived friend social support was positively associated with life satisfaction and positive future feelings and negatively associated with loneliness and loss of motivation. Both loneliness and life satisfaction individually and serially mediated the relationships between social support and the dimensions of hopelessness. Conclusion: These results highlight the crucial role of friend-based social support in alleviating loneliness and improving life satisfaction, thereby fostering optimism and preventing motivational decline among students. The findings provide valuable insights for designing interventions to enhance emotional well-being and psychological resilience among university populations.
Citation - WoS: 1
Citation - Scopus: 1
Determining the Knowledge Levels and Opinions of Athletes Who Is Age Under-16 in Different Branches About Doping and Ergogenic Aids
(Mattioli 1885, 2020) Ceylan, Abdil; Calik, Febmi; Geri, Serdar; Sen, Murat; Ece, Cuma; Sumer, Mebmet
Study Objectives: The study aimed to evaluate the knowledge levels and opinions of athletes under 16 years of age about doping and ergogenic aids in different branches. The fact that there are no studies in the literature on the knowledge and opinions of athletes under the age of 16 on doping and ergogenic aids has encouraged us to the study. Methods: The sample of the study consists of 392 athletes under 16 years of age in different sports branches. In the study, a questionnaire consisting of 5 likert and 26 questions about doping substances and ergogenic aids was applied to the athletes by Eroz (2007). Results: As a result of the analysis of the obtained findings with the Chi-square test, it was determined that as the age of the athletes increased, the belief that the athlete used doping increased with the fear of losing. It has been determined that as the family income increases, the tendency to try every way to be successful does not decrease significantly, and athletes with low family income are more willing to try every way to be successful. As the education of the athlete's parents increased, the belief that the use of doping harmed the Fair-Play spirit in sports and that doping leads to unfair competition has been increased. Conclusion: The study revealed that there is a need to reinforce the doping knowledge of athletes. It has been concluded that certain socio-economic conditions are determinants in the use of doping by athletes and that they shape their tendency towards doping. Therefore, it is thought that the trainers, managers, athlete families and athletes about the negative effects of doping use on athlete health is of great importance.
Citation - WoS: 25
Citation - Scopus: 30
Exploring the Stakeholder's Role in Sustainable Degrowth Within the Context of Tourist Destination Governance: the Case of Istanbul, Turkey
(Routledge Journals, Taylor & Francis Ltd, 2020) Cakar, Kadir; Uzut, Ismail
The aim of the present study is to explore the role of tourism stakeholders in the sustainable degrowth of tourism, within the context of overtourism and destination governance. Data was gathered from document analysis and in-depth, face-to-face interviews with key tourism stakeholders in Istanbul, the most popular tourist destination in Turkey. A qualitative case study approach was adopted and content analysis was utilized as a data treatment technique. The results indicate that demarketing and applying "localhood" tourism activities are key drivers behind degrowth. Findings have also confirmed that degrowth is one solution in response to the concept of overtourism.
The Contribution of Trading Colonies Founded in Levant in Protodynastic and Early Dynastic Period (BC 3300-3000) to Egypt's Becoming a State
(Karabuk Univ, 2014) Civgin, Izzet
This study is the fourth of an article series dedicated to colonization as a cause of cultural change. It discusses the effects of culture contact between lower (northern) and upper (southern) Egypt and the southern Levant during so- called Naqada expansion (widespread distribution of southern material culture at sites at the northern Egypt), and Egyptian colonization of the southern Levant assumed to be founded in the last quarter of the 4th millennium B.C. The ultimate objective of this study is to examine the relationship between long-distance trade, colonization and the state formation (state ideology, emergence of early elites, specialized craft production and political economy).
Citation - WoS: 2
Citation - Scopus: 2
Architecture After Crisis a Journey Through Contemporary Commoning Practices
(Pontificia Univ Catolica Chile, Escuela Arquitectura, 2015) Tan, Pelin
After the economic crisis of 2008 many architects have devoted to the search of an alternative and communal production model capable of exploring diverse parallel platforms without having to cave in to the pressures of a capitalist economy. This text presents a journey through several contemporary examples, analyzing the possibilities that arise when commonality replaces professionalization in architecture.
Decarbonizing Buildings With Autoclaved Aerated Concrete (AAC): Climate-Specific Meta-Analysis of Global Performance
(Taylor & Francis Ltd, 2025) Azhar, Jasim; Aydin, Serdar; Zami, Mohammad Sharif
The building sector, which accounts for 40% of global energy consumption and 36% of CO2 emissions, requires immediate access to scalable low-carbon materials. The theoretical thermal advantages of Autoclaved Aerated Concrete (AAC) remain incomplete because field performance reports show inconsistent results between 15% and 50% energy savings, and multiple unaddressed implementation challenges have prevented its strategic adoption. The systematic review used worldwide climate-based empirical data to resolve existing performance discrepancies and develop practical implementation strategies. The meta-analysis of 12 studies comprising 847 dwelling units, assessed using CASP and ROBINS-I quality tools, showed that energy savings depend on climate zone: hot-arid zones achieving 48.3% (95% CI: 42.1-54.5%), cold-temperate zones 32.7% (27.3-38.1%), and hot-humid zones 28.4% (22.9-33.9%). The strongest predictor of performance was cooling degree days (beta = 0.0089, p < 0.001), while implementation quality explained 26% of performance variation. Economic modelling revealed median payback periods from 4.2 years (hot-arid) to 9.7 years (cold-temperate), with a 78-92% probability of positive lifetime returns. Carbon pricing at $50/tCO(2) reduces payback by 23%. The research develops a climate-oriented analytical system that analyses performance variations to help designers and policymakers achieve maximum AAC decarbonization results by combining environmental data with system information and financial metrics. [GRAPHICS] .
Citation - WoS: 11
Citation - Scopus: 12
The Effectiveness of HALP Score in Predicting Mortality in Non-ST Myocardial Infarction Patients
(Lippincott Williams and Wilkins, 2025) Kiliç, R.; Guzel, T.; Aktan, A.; Güzel, H.; Kaya, A.F.; Çankaya, Y.
Background: The HALP score, measured based on hemoglobin, albumin, lymphocyte, and platelet levels, is regarded as a novel scoring system that indicates the status of systemic inflammation and nutritional health. Our study aimed to evaluate the relationship between HALP score and prognosis in non-ST-elevation myocardial infarction (NSTEMI) patients. Methods Between 1 January 2020 and 1 January 2022, 568 consecutive patients diagnosed with NSTEMI from a single center were included in the study retrospectively. The patients were divided into two equal groups according to the median HALP cutoff value of 44.05. Patients were followed for at least 1 year from the date of admission. Results The average age of the patients was 62.3±10.6 years and 43.7% were female. In-hospital and 1-year mortality were found to be significantly higher in the group with low HALP scores (6.0 vs. 2.1%, P=0.019 and 22.5 vs. 9.9%, P<0.001, respectively). In receiver operating characteristic curve analysis, a cutoff level of 34.6 of the HALP score predicted 1-year mortality with 71% sensitivity and 65% specificity (area under the curve: 0.707, 95% confidence interval: 0.651-0.762, P<0.001). In Kaplan-Meier analysis, higher mortality rates were observed over time in the group with lower HALP scores (log-rank test=16.767, P<0.001). In Cox regression analysis, the HALP score was found to be an independent predictor of 1-year mortality (odds ratio: 0.969, 95% confidence interval: 0.958-0.981, P<0.001). Conclusion We found that a low HALP score could predict in-hospital and 1-year mortality in patients admitted to the hospital with a diagnosis of NSTEMI. © © 2024 Wolters Kluwer Health, Inc. All rights reserved.
Qualitative Analysis of Solutions for a Timoshenko Type Equation With Logarithmic Source Term
(Univ Nis, 2025) Dinc, Yavuz; Irkil, Nazli; Piskan, Erhan; Tunc, Cemil
This paper deals with a Timoshenko type equation with strong damping and logarithmic source terms. The global existence and the decay estimate of the solutions have been obtained. We reproduce the finite time blow up results of weak solutions by the combining of the concavity method, perturbation energy method and differential-integral inequality technique. These results extend and improve some recent results in logarithmic nonlinearity.
Citation - WoS: 5
Citation - Scopus: 5
Deep Learning-Based Artificial Intelligence Can Differentiate Treatment-Resistant and Responsive Depression Cases With High Accuracy
(Sage Publications inc, 2025) Metin, Sinem Zeynep; Uyulan, Caglar; Farhad, Shams; Erguzel, Tuerker Tekin; Turk, Omer; Metin, Baris; Tarhan, Nevzat
Background: Although there are many treatment options available for depression, a large portion of patients with depression are diagnosed with treatment-resistant depression (TRD), which is characterized by an inadequate response to antidepressant treatment. Identifying the TRD population is crucial in terms of saving time and resources in depression treatment. Recently several studies employed various methods on EEG datasets for automatic depression detection or treatment outcome prediction. However, no previous study has used the deep learning (DL) approach and EEG signals for detecting treatment resistance. Method: 77 patients with TRD, 43 patients with non-TRD, and 40 healthy controls were compared using GoogleNet convolutional neural network and DL on EEG data. Additionally, Class Activation Maps (CAMs) acquired from the TRD and non-TRD groups were used to obtain distinctive regions for classification. Results: GoogleNet classified the healthy controls and non-TRD group with 88.43%, the healthy controls and TRD subjects with 89.73%, and the TRD and non-TRD group with 90.05% accuracy. The external validation accuracy for the TRD-non-TRD classification was 73.33%. Finally, the CAM analysis revealed that the TRD group contained dominant features in class detection of deep learning architecture in almost all electrodes. Limitations: Our study is limited by the moderate sample size of clinical groups and the retrospective nature of the study. Conclusion: These findings suggest that EEG-based deep learning can be used to classify treatment resistance in depression and may in the future prove to be a useful tool in psychiatry practice to identify patients who need more vigorous intervention.
Seasonal Variation on Phospholipid Classes, Triacylglycerols and Atherogenic, Thrombogenic Indices of Male chondrostoma Regium
(Japan Oil Chemists Soc, 2024) Kacar, Semra; Kaya, Hacer Kayhan; Bashan, Mehmet
Gas chromatography (GC) was used to determine the fatty acid (FA) compositions of total lipid, phospholipid (PL), phospholipid subclass (phosphatidylcholine (PC), phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylethanolamine (PE)), and TAG (triacylglycerol) fractions in male Chondrostoma regium. Percentages of myristic acid (14:0), palmitoleic acid (16:1n-7), oleic acid (18:1n-9), monounsaturated fatty acid (Sigma MUFA), linoleic acid (18:2n-6) and linolenic acid (18:3n-3) were found to be higher in TAG than the values determined in PL classes. Palmitic acid (16:0), eicosapentaenoic acid (EPA, 20:5n-3), docosahexaenoic acid (DHA, 20:6n-3) in the PC fraction; 16:0, 20:5n-3, 22: 6n-3 in PE; 16:0, stearic acid (18:0), arachidonic acid (AA, 20:4n-6), 20:5n-3, 22:6n-3 in PI; and 16:0, 18:0, oleic acid (18:1n-9), 22:6n-3 in PS were found to be dominant. In total lipid, the PUFA/SFA ratio was 1.37-1.83; atherogenicity index (AI) was 0.34-0.47 and thrombogenicity index (TI) was found in the range of 0.18-0.22. The n-3/n-6 ratio, which is an important index for nutritional content, was found to be between 5.15 and 11.07. It was discovered that the FA compositions of male C. regium were affected by the reproductive period and season. These findings suggest that fish oil might be a beneficial dietary source for preserving human health.
The Effects of Elicitor and Abiotic Stressor Molecules on Phenolic Composition of in Vitro Callus Cultures of Elecampane (Inula Helenium L.)
(Soc Stiinte Farmaceutice Romania, 2025) Battal, Peyami; Akcura, Gokhan; Turker, Musa; Dalar, Abdullah
This study focused on the effects of various stressors and elicitors on phenolic metabolism of in vitro callus cultures of Elecampane. 1 mg/L 2,4-Dichlorophenoxyacetic acid (2,4-D) + 0,3 mg/L Kinetin (KN) formulation was detected as the most proper application for callus production. Quercetin was synthesized as the dominant phenolic compound of callus cultures. The highest values of total phenolics were obtained through the combination of 6-Benzylaminopurine + 1-Naphthaleneacetic acid (BAP+NAA) in the plant growth regulators (PGR) group (169 mu g/g), 1/2 reduced Murashige and Skoog medium (MS) (108 mu g/g) in the stressor group, and both abscisic acid (140 mu g/g) and melatonin (138 mu g/g) in the elicitor group. The application of various PGRs and elicitors enhanced the level of quercetin at pronounced levels (241-388 mu g/g), but not in rutin (3-18 mu g/g). Chlorogenic acid increased under silver nitrate (19 mu g/g) and 1/4 reduced MS stressors (17 mu g/g) and melatonin (32 mu g/g) and abscisic acid (24 mu g/g) elicitors. These findings suggest that the combination of 2,4-D + KN, reduced MS, abscisic acid, and melatonin conditions stimulated the synthesis of phenolics through the biosynthetic pathway by increasing the stress resistance of Elecampane.
Cytotoxic Effect of Zinc Oxide and Selenium Nanoparticles Synthesized From Orobanche Picridis on Lung Cancer as Well as Their Antimicrobial and Antioxidant Properties
(Wiley, 2025) Ercan, Leyla; Caliskan, Cemile Gunbegi
Orobanche picridis represents a fascinating example of an obligate parasitic plant due to its lack of chlorophyll. It is of significant interest to botanists, ecologists, and biologists because of its complex parasitic lifestyle and specific host preferences. The purpose of this work was to generate zinc oxide (OrZnO) nanoparticles (NPs) and selenium (OrSe) nanoparticles from O. picridis and examine their characterization as well as their antibacterial, anticarcinogenic, and antioxidant characteristics. To this purpose, the produced NPs were characterized utilizing a scanning electron microscope, energy-dispersive X-ray spectroscopy, X-ray diffraction, and Fourier-transform infrared spectroscopy. The antimicrobial activity of OrZnO and OrSe NPs was assessed employing the disc diffusion and agar well diffusion methods, while in vitro antioxidant activity was assessed through three different assays: DPPH, FRAP, and ABTS. The MTT assay was utilized to ascertain the cytotoxicity of these nanoparticles against lung cancer, and acridine orange/ethidium bromide staining was carried out to analyze morphological and DNA alterations in these cells. Consequently, the synthesized OrZnO NPs exhibited stronger antibacterial capabilities than the OrSe NPs, while both demonstrated antioxidant properties. In addition to their potent cytotoxic action, both NPs induced apoptosis by altering the DNA and shape of the lung cancer (A549) cells.
Citation - WoS: 1
Citation - Scopus: 1
Determination of Bioactive and Anti-Inflammatory Molecules of Thymbra Spicata L. from Mardin by GC-MS and LC-Orbitrap HRMS: A DFT, Molecular Docking, ADMET, Biological Target and Activity Study
(BMC, 2025) Unsal, Velid; Ercan, Leyla; Caliskan, Cemile Gunbegi
Objectives In this study, phenolic compounds (PC), volatile compounds (VC), antioxidant, anti-inflammatory, and antimicrobial properties of the Thymbra spicata L. plant grown in the Mardin Yesilli region were investigated. The properties of compounds such as rhoifolin, leucoside, naringenin, rosmarinic acid, gamma-terpinene, and carvacrol, which were found to be higher than other compounds as a result of PC and VC analysis of Thymbra spicata L. plant, and the properties of non-steroidal anti-inflammatory drugs diclofenac and ketoprofen were compared with computer-based calculations. In this context, the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) profiles of the mentioned molecules were calculated, Density Functional Theory (DFT)-based quantum chemical calculations were performed, and molecular docking analyses were performed. In addition, the pharmacological properties, biological targets, and biological activities of these compounds were comprehensively evaluated. This study provides important data for understanding the therapeutic potential of these plant components. Materials and methods Chromatographic methods (GC-MS and LC-Orbitrap HRMS) were used to look at PC and VC profiles, spectrophotometry (ABTS, DPPH, CUPRAC) to look at antioxidant activities, and the disk diffusion method to look at antimicrobial properties. Results While the most detected volatile compounds were gamma-terpinene (35.34%), carvacrol (17.55%), caryophyllene (10.53%), and p-cymene (9.15%), the most detected phenolic compounds were rosmarinic acid (3334.9 ng/mL), naringenin (2610.00 ng/mL), leucoside (1956.42 ng/mL), and rhoifolin (1288.55 ng/mL). The ethanol extract of Thymbra spicata L. stopped the growth of K. aerogenes in particular. The IC50 value for DPPH was 158.01 mu g/mL, the IC50 value for ABTS was 185.03 mu g/mL, and the C0.5A value was 87.13 for the ethanol extract of Thymbra spicata L. The molecular docking results that the strongest binding energy was between TNF-alpha and naringenin (-6.77 kcal/mol), IL-6 and rosmarinic acid (-5.55 kcal/mol), and NLRP3 and carvacrol (-6.88 kcal/mol). Naringenin, rosmarinic acid, diclofenac, and ketoprofen completely violated the restrictions established by Lipinski, Ghose, Veber, Egan, and Muegge. Rosmarinic acid is the most reactive antioxidant compound with low energy deficit (Eg) and high softness (S). gamma-terpinene and carvacrol, on the other hand, are more stable and durable wit high hardness (eta) and low softness. Conclusion Naringenin, rosmarinic acid, and carvacrol demonstrate significant anti-inflammatory and immunomodulatory properties owing to their high binding affinity for TNF-alpha, IL-6, and NLRP3, positioning them as promising candidates for the treatment of inflammatory disorders. Naringenin and rosmarinic acid effectively target TNF-alpha, whereas carvacrol demonstrates potential in the management of NLRP3 inflammasome-associated diseases. The strong binding of rosmarinic acid to IL-6 shows that it can change the immune system. Thymbra spicata L., abundant in bioactive compounds, may provide benefits compared to conventional NSAIDs and exhibit potential as monotherapy or adjunctive therapies. Their strong anti-inflammatory, antioxidant, antimicrobial, and pharmacological properties, along with their safety, make naringenin, rosmarinic acid, and carvacrol good candidates for more preclinical and clinical research.
Citation - WoS: 2
Citation - Scopus: 2
Can Quercetin Reduce Arsenic Induced Toxicity in Mouse Balb/C 3t3 Fibroblast Cells ? A Study Involving in Vitro, Molecular Docking, and Adme Predictions
(Bmc, 2025) Unsal, Velid; Keskin, Cumali; Oner, Erkan
This study aimed to investigate the protective effect of quercetin against arsenic-induced oxidative damage, inflammation, and apoptosis in mouse BALB/c 3T3 fibroblast cells (NIH-3T3). Arsenic at different concentrations of 0.05 mu M (low), 0.5 mu M (medium), 10 mu M (high) doses were used to induce toxicity, while 120 mu m quercetin was used for treatment. MTT and LDH analyses were performed to determine the effect of arsenic and quercetin on cell viability, while oxidative stress markers and antioxidant enzyme activities were measured by spectrophotometric method. TNF-alpha and IL-1 beta levels were measured by the ELISA method, Autodock programs were used for molecular docking studies. In addition, computer-based analyses of quercetin and succimer molecules were performed using SwissADME web tools. TNF-alpha (PDB ID: 2AZ5), IL-1 beta (PDB ID: 1ITB), Caspase3 (PDB ID: 2XYG), Bax (PDB ID: 4S0O), SOD (PDB ID:1CBJ), GSH-Px (PDB ID: 1GP1) and Bcl-2 (PDB ID: 1G5M) crystal structures were obtained from the Protein Data Bank. Bax and Bcl-2 levels of apoptotic genes and mRNA expression levels of Caspase-3 activity were measured using the QRT-PCR technique. TUNEL staining was performed to determine DNA fragmentations, while DAPI staining was done to visualise nuclear modifications. Quercetin has been found to significantly reduce oxidative stress, inflammation, and apoptosis in cells and exert anti-apoptotic effects. Molecular docking studies revealed quercetin shows good binding affinity with molecules with SOD, GSH-Px, Bax, Bcl-2, Caspase-3, TNF-alpha and IL-1 beta structures, and has been observed to bind with Bax and Bcl-2 with molecular docking scores of -7.5 and - 7.7 kcal/mol, respectively. These findings are supported by results showing that quercetin is effective in anti-apoptotic and anti-inflammatory processes in arsenic-induced cells under in vitro conditions. In addition, when ADME values are examined, it can be considered that quercetin is a useful and effective candidate compound in reducing arsenic toxicity, considering its higher synthetic accessibility score, better pharmacokinetic properties, and good biological transition and interaction capacities compared to succimer.
Citation - WoS: 3
Citation - Scopus: 3
Muay Thai Exercises Improve Quality of Life, Love of Life and Self-Control
(Frontiers Media Sa, 2025) Sahin, Oktay; Yilmaz, Coskun; Sezer, Sureyya Yonca; Sahin, Fatma Nese; Ceylan, Levent; Celikel, Baha Engin; Kirikoglu, Nagihan
Background The existing research on Muay Thai sports has focused predominantly on the physiological effects of training, with limited attention devoted to the study of quality of life, love of life and self-control. The present study examined the effects of Muay Thai exercises on quality of life, love of life and self-control scores in healthy male subjects. Methods The present study comprised 50 healthy sedentary male subjects. The subjects were randomly divided into two groups: one group engaged in Muay Thai training (MTT), while the other group served as a control group (CON). The sample sizes for the MTT and CON groups were both 25. The MTT group participated in basic Muay Thai training, while the CON group continued their normal life regime. The SF-12 quality of life scale, love of life scale and multidimensional self-control scale were administered before and after the six-week training period. Results The study concluded that the six-week Muay Thai training program had a significant effect on quality of life levels, with 13.23% (p = 0.003) and 21.93% (p < 0.001) of participants demonstrating improvements in physical and mental scores, respectively. In terms of self-control levels, the program was found to have a significant effect on initiation and inhibition scores, with increases of 23.78% (p = 0.001) and 24.69% (p < 0.001), respectively. It was concluded that had a significant effect on the sub-dimensions of the Love of Life scale with increases of Positive Attitude Toward Life (PAWL) 18.63% (p < 0.001), Happy Results of the Love of Life (HRLL) 20.11% (p < 0.001) and Meaningfulness of Life (ML) 15.62% (p < 0.001), respectively. However, no significant differences were detected in any of the scales within the control group. Conclusion Muay Thai exercises had a positive effect on quality of life, love of life and self-control levels in healthy male subjects. By providing valuable insights into how Muay Thai exercise affects quality of life, love of life, and self-control, this research can guide future intervention and program design in the context of sport psychology.
Citation - WoS: 1
An Empirical Investigation on Growth and Institutional Structure Relations in Central Asian and Caucasian Countries
(Ege Univ, Fac Economics & Admin Sciences, 2023) Cuhadar, Pinar; Kıran Bulgurcu, Berna
Whether economic and political institutions have an impact on countries' economic growth performances is one of the important research topics discussed in the literature. Former socialist Central Asian and Caucasian countries trying to adapt into market economy have not yet completed their transition processes, but they have managed to grow their economies in comparison to previous periods. The aim of this study is to analyse the relationship between the growth performances and institutional structures of the Central Asian and Caucasian countries of Azerbaijan, Armenia, Georgia, Kazakhstan, Kyrgyzstan and Tajikistan between the years 2000-2018 by using the decision variables of civil rights, economic freedom, political stability, rule of law and GDP per capita. According to the analysis results obtained via Grey Relational Analysis method by assigning equal importance to all variables, Kazakhstan is found to be the highest-ranking country among all examined countries for all periods. The authoritarian tendencies that these countries have shown during their market economy transitions with regards to matters related to institutional structure have been found to be the reason why countries' economic efforts have failed to yield results.

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