Beslenme ve Diyetetik Bölümü Koleksiyonu

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Citation - WoS: 9
Citation - Scopus: 10
Assessment of renal function in obese and overweight children with ngal and kim-1 biomarkers
(Nutricion Hospitalaria, 2020) Unsal, Velid; Gül, Ali; Yılmaz, Resul; Özmen, Zeliha Cansel; Demir, Osman; Gümüşer, Rüveyda
Aim and background:the incidence of obesity has increased among children, and obesity has been considered an independent risk factor for chronic kidney disease. We aimed to determine the degree of kidney function impairment by evaluating urine neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) levels. Materials and methods: in total, 15 obese, 26 overweight, and 26 control adolescents aged 10 to 16 years were enrolled into the study. Urine samples were evaluated for NGAL and KIM-1 levels using enzyme-linked immunosorbent assay kits. We investigated the association between obesity and related comorbidities with urinary NGAL and KIM-1 excretion. Results: no significant differences were noted between the obese, overweight, and control groups in urinary NGAL and KIM-1 excretion (p = 0.327 and p = 0.917, respectively). In the obese and overweight groups urinary NGAL levels were 50.39 [30.88-74.22] in females and 26.67 [23.24-45.59] in males (p = 0.013). Also, urinary NGAL levels were increased in obese and overweight adolescents with LDL dyslipidemia at 64.12 [30.98-114.32] as compared to those without LDL dyslipidemia: 39.51 [25.59.56.37] (p = 0.024). Furthermore, a correlation was observed between insulin and homeostasis model assessment of insulin resistance levels with the NGAL/creatinine ratio in the overweight group (r = 0.515; p = 0.008, and r = 0.483; p = 0.014, respectively). Such correlation was not found in the obese group. Conclusion: the effect of obesity on renal function could not be determined in children. A longer exposure may be required for obesity-induced disruption of renal function in children. Renal function may be disrupted by dyslipidemia in obese adolescents. Furthermore, obesity impaired renal function in female adolescents. The normalization of these urinary markers as related to urine creatinine should be discussed.
Clinical Relevance of Preoperative Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratio in Renal Cell Carcinoma
(Journal of Urological Surgery, 2018) Kölükçü, Engin; Kılıç, Şahin; Atılgan, Doğan; Parlaktaş, Bekir; Ceylan, Salih; Unsal, Velid; Etikan, İlker
Objective: The association of preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with postoperative tumor stage and Fuhrman nuclear grade was investigated in patients with renal cell carcinoma (RCC). Materials and Methods: Data of 123 patients, who were operated due to RCC, in our clinic was analysed. NLR and PLR were evaluated in patients who were classified according to tumor stage (T1 and T2 low stage, T3 and T4 high stage) and Fuhrman nuclear grade (grade 1 and 2 low-grade, grade 3 and 4 high-grade). NLR and PLR were compared using Levene’s test between the groups. Results: Sixty four patients were female (52.1%) and 59 were male (47.9%). All haematological parameters were expressed as 103 /μL. Mean age, blood neutrophil, lymphocyte and platelet counts, and NLR and PLR values of the patients were 62.49±12.43 years, 6.27±2.8, 2.05±0.83, 263.72±89.03, 4.01±3.93, and 149.73±82.1, respectively. The most common histologic subtype was recorded as clear cell RCC (76.4%). NLR and PLR were 3.83±3.22 and 142.79±66.66, respectively in the low-stage group and 4.43±5.29 and 165.85±109.41, respectively in the high stage group. As for the Fuhrman nuclear grading, NLR and PLR were 3.81±3.45 and 146.63±87.36, respectively in the low-grade group and 4.61±5.387 and 159.32±63.42 in the high-grade group. There was no statistically significant difference between the groups (p>0.05). Conclusion: Although not statistically significant, high tumor stage and nuclear grade were positively correlated with NLR and PLR. It is concluded that, further multi-center and prospective studies with larger samples are needed to derive meaningful results.
Citation - WoS: 4
Citation - Scopus: 6
Effect of seasons on the fatty acid profile of total lipid, phospholipid and triacylglycerol in Mastacembelus mastacembelus (Atatürk Dam Lake, Turkey).
(2018) Kaçar, Semra; Başhan, Mehmet; Oymak, Ahmet
The present study investigated the lipid content and FA profiles of total lipids, phospholipids (PL) and triacylglycerols (TAG) of Mastacembelus mastacembelus from the Atatürk Dam Lake (Turkey). The results showed that the total lipid content of the dorsal muscle varied seasonally from 0.50% to 3.59%. Wide ranges of saturated fatty acids (SFAs) (36.21 to 50.52%) and polyunsaturated fatty acids (PUFAs) (25.22 to 42.02%) were found in the PL fraction. However, higher monounsaturated fatty acids (MUFAs) (37.63 to 45.07%) and SFA (34.71 to 38.82%) were found in TAG (triacylglycerol). The ratios of ω-3 to ω-6 PUFA ranged from 0.65 to 1.32 and 1.07 to 3.48 in PL (phospholipid) and TAG fraction, respectively. The results also showed that the major components were palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1ω-9), palmitoleic acid (C16:1ω-7), docosahexaenoic acid (DHA, C22:6ω-3), arachidonic acid (AA, C20:4ω-6) and docosapentaenoic acid (C22:5ω-3) in total lipid, C16:0, C18:1ω-9, AA and DHA in PL, C16:0, C16:1ω-7, C18:1ω-9, linoleic acid (LA, C18:2ω-6), and DHA in TAG extracted from the muscle of M. mastacembelus in all seasons.
Citation - WoS: 14
Citation - Scopus: 15
Experimental and theoretical investigation of pyrazinecarboxamide against mild steel corrosion
(Journal of Dispersion Science and Technology, 2021) Keleşoğlu, Ayşen; Sığırcı, Gökmen; Yıldız, Reşit; Dehri, İlyas
Pyrazinecarboxamide was examined against mild steel corrosion in 0.5 M HCl solution. The electrochemical techniques like electrochemical impedance spectroscopy, linear polarization resistance and potentiodynamic polarization measurements were carried out in the presence of various concentrations of pyrazinecarboxamide ranging from 0.25 mM to 1.0 mM. The inhibition effect of pyrazinecarboxamide on the mild steel surface was studied by atomic force microscopy and scanning electron microscopy. The adsorption of this inhibitor was determined to fit Langmuir adsorption isotherm. The adsorption/desorption equilibrium constant was calculated as 2.985 × 104 M−1, indicating that high proportion of pyrazinecarboxamide takes place on mild steel surface. The inhibition efficiency was found as 93.5% from electrochemical impedance spectroscopy measurement in an acid solution containing 1.0 mM pyrazinecarboxamide. Quantum chemical parameters that were in good agreement with experimental results were determined by density functional theory.
Citation - WoS: 1
Citation - Scopus: 1
Fatty acid compositions of colostrum and mature breast milk in Turkey (Mardin)
(Acta Alimentaria, 2023) Kaçar, Semra; Başhan, Mehmet; Keskin, Cumali
In this study, 25-25 milk samples (25 colostral and 25 mature) collected at different lactational stages were used to analyse the fatty acid composition of breast milk. A gas-chromatographic method was used to perform and analyse the transmethylation of total milk lipid extracts. The milk samples contained 20 different fatty acids. Palmitic acid (C16:0), stearic acid (C18:0), myristic acid (C14:0), oleic acid (C18:1n-9), and linoleic acid (LA, C18:2n-6) were the major components of total lipid, phospholipid (PL), and triacylglycerol (TAG) fractions. Colostrum had a lower percentage of polyunsaturated fatty acids (PUFAs), a higher percentage of saturated fatty acids (SFAs), and a lower level of eicosapentaenoic acid (EPA, C20:5 n-3) and docosahexaenoic acid (DHA, C22:6 n-3) in total lipid than mature milk. Triacylglycerol and PL fractions between colostrum and mature milk samples did not differ statistically. © 2023 Akadémiai Kiadó, Budapest.
Citation - WoS: 4
Citation - Scopus: 5
Green biosynthesis of silver nanoparticles using Prunus cerasifera pissardii nigra leaf and their antimicrobial activities against some food pathogens
(Czech Journal of Food Sciences, 2022) Hatipoğlu, Abdulkerim
In this study, silver nanoparticles (AgNPs) were synthesised using the Prunus cerasifera pissardii nigra (PC) leaf extract in an easy, low-cost and environmentally friendly way. According to the ultraviolet-visible (UV-vis) spectrophotometer analysis data, the nanocrystals demonstrated a characteristic peak at 456 nm. Scanning electron microscopy (SEM), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) and energy-dispersive X-ray (EDX) spectroscopy analyses revealed that the morphological structures of the biosynthesised AgNPs were mostly spherical. According to the results of X-ray diffraction (XRD) analysis, it was determined that the crystal structures of AgNPs were cubic. The size of the nanoparticles was calculated as 23.60 nm using the Debye-Scherrer equation. The zeta potential of the synthesised nanomaterial was measured as –15.5 mV. The minimum inhibitory concentration (MIC) values of AgNPs on Staphylococcus aureus ATCC 29213, Escherichia coli ATCC 25922, Bacillus subtilis ATCC 11774, Pseudomonas aeruginosa ATCC 27853 and Candida albicans ATCC 10231 were determined to be 0.062, 0.250, 0.125, 0.500 and 0.125 µg mL–1, respectively
Citation - WoS: 14
Citation - Scopus: 16
Green synthesis of gold nanoparticles from prunus cerasifera pissardii nigra leaf and their antimicrobial activities on some food pathogens
(Progress in Nutrition, 2021) Hatipoğlu, Abdulkerim
In this study, a new and easy method for the biosynthesis of gold nanoparticles (AuNPs) with Prunus cerasifera pissardii nigra (PC) leaf extract as a reducing and stabilizing agent was presented. The nanoparticles were demonstrated a characteristic peak at the maximum wavelength of 535 nm with colour change as a result of the ultraviolet (UV)-visible spectrophotometer analysis data. Emission Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDX) analyzes revealed that the crystal size of the synthesized AuNPs was below 20 nm and the morphological structure was mostly spherical. The size of the crystal structures of AuNPs was calculated as 17.94 nm from the X-ray diffraction (XRD) analysis data. Fourier Transform Infrared (FT-IR) Spectroscopy results confirmed the involvement of various biomolecules in the reduction and stabilization of PC-AuNPs. The zeta potential of the synthesized nanomaterial was measured as -27 mV. The average size of AuNPs was determined as 103.8 nm with Zetasizer. It was determined that AuNPs have strong inhibitory activity against Escherichia coli, Staphylococcus aureus, Bacillus subtillis and Pseudomonas aeruginosa and Candida albicans.
Citation - Scopus: 1
The interaction methylene blue and glutathione-S-transferase purified from human erythrocytes
(Journal of Planar Chromatography - Modern TLC, 2020) Acay, Hilal; Uzan, Serhat; Baran, Mehmet Fırat; Bilden, Alican; Aygün, Hüsamettin
It is known that textile dyes have various risks on human health. Glutathione-S-transferase enzymes play a critical role in the detoxification of xenobiotics in living systems. This study aimed to examine the interaction of methylene blue with human erythrocyte glutathione-S-transferase purified in one step. Human erythrocyte glutathione-S-transferase was purified with approximately 750-fold purification and 30% efficiency by glutathione agarose affinity chromatography. The results showed that the enzyme was inhibited by methylene blue with an IC50 value of 1.40 mmol/L. The Ki constant of methylene blue was 1.17 mmol/L. The Lineweaver–Burk graph of the methylene blue showed that the type of inhibition was compatible with mixed type inhibition. A new third spot was also detected by thin-layer chromatography. Furthermore, the cytotoxicity of methylene blue on human erythrocytes was evaluated and it was found that the haemolysis per cent of methylene blue on erythrocytes was approximately 14%.
Citation - WoS: 6
Citation - Scopus: 3
Protective effects of apocynin and melatonin on ovarian ischemia/reperfusion injury in rats
(Clinical and Experimental Obstetrics and Gynecology, 2021) Unsal, Velid; İşgüder, Çiğdem Kunt; Can, Özlem Koşar; Pektaş, Mine Kanat; Arici, Akgül
Objective: This study aims to determine the protective effects of apocynin, a NADPH oxidase inhibitor, and melatonin, an endogenous anti-oxidant, in an animal model of ovarian ischemia/reperfusion (I/R) injury. Materials/Methods: Thirty-five female rats were randomly divided into five groups, namely group I (sham), group II (I/R), group III (I/R + 10 mg/kg apocynin), group IV (I/R + 20 mg/kg apocynin), and group V (I/R + 10 mg/kg melatonin). Ovarian tissue and serum superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) and protein carbonyl (PC) levels were measured. Ovarian histopathology was examined and Bax, caspase 3, and iNOS immunoreactivities were evaluated. Results: Preoperative apocynin and melatonin significantly increased SOD and CAT activities (P < 0.05, P < 0.05, P < 0.01, P < 0.01, P < 0.01, P < 0.05, P < 0.05, and P<0.01, respectively, for both apocynin and melatonin). In addition, preoperative apocynin and melatonin significantly decreased the ovarian I/R injury score (P < 0.01 for both). Bax, caspase 3, and iNOS immunoreactivities were significantly lower in the I/R + 10 mg/kg apocynin and I/R + 10 mg/kg melatonin groups than in the I/R group (P<0.01, P<0.01, P<0.01, P<0.01, P<0.05, and P<0.01, respectively). Conclusions: Apocynin and melatonin are powerful antioxidant agents with considerable bioavailability and safety. Preoperative apocynin and melatonin administration might protect ovarian tissue from I/R injury after surgical adnexal detorsion.
Citation - WoS: 6
Citation - Scopus: 5
The protective effects of sinapic acid on acute renal ischemia/reperfusion injury
(Turkish Journal of Biochemistry, 2021) Unsal, Velid; kolukcu, Engin; Firat, Fatih; Gevrek, Fikret
Objectives: The aim of this research was to investigate whether sinapic acid (SA) can alleviate oxidative damage, apoptosis, and inflammation in I/R induced renal injury. Methods: A total of 24 male rats were randomly separated into four groups as six rats in each group. Group 1 (Sham), Group 2 (I/R), Group 3 (I/R + SA, 10mg/kg), Group 4 (I/R + SA, 20 mg/kg). In order to evaluate kidney function serum BUN, Cr, and AST were measured in an autoanalyzer. SOD, GSH-Px, MDA, PC and NO oxidative stress parameters were measured with spectrophotometric methods and TNF-α, IL-1β, IL-6, KIM-1 and NGAL parameters were measured with the ELISA method. In addition, H&E method and immunohistochemical examinations were performed for histological evaluations of kidney tissue. Results: SA significantly decreases the increase in kidney damage, inflammation, oxidative stress, cell death and restore the decrease in antioxidant enzyme activities (p<0.05). Pre-treatment of the rats with SA reduces kidney dysfunction and morphological changes. Conclusions: The development of oxidative stress and lipid peroxidation seems to be the leading factors that accelerate inflammation and cell death during renal IRI. The antioxidant, anti-inflammatory, and anti-apoptotic features of SA displayed a renoprotective effect.
Citation - WoS: 17
Citation - Scopus: 22
Rapid green synthesis of gold nanoparticles: synthesis, characterization, and antimicrobial activities
(Progress in Nutrition, 2021) Hatipoğlu, Abdulkerim
In this research, an easy and environmentally friendly method was presented for the biosynthesis of gold nanoparticles (AuNPs) with Allium ampeloprasum (AA) leaf extract as a reducing and stabilizing agent. The maximum absorption peak was found to be around 535 nm with ultraviolet (UV)-visible spectrophotometer. When the Transmission Electron Microscopy (TEM), Emission Scanning Electron Microscopy (FE-SEM) and energy dispersive X-ray (EDX) analyzes were examined, it was seen that the crystal size of the synthesized AuNPs was between 6.02-17.36 nm and their shape was mostly spherical. The size of the crystal structures of AuNPs was calculated as 22.76 nm from the X-ray diffraction (XRD) analysis data. Fourier Transform Infrared (FT-IR) Spectroscopy results showed that phenolics, aromatic compounds and proteins were effective in the reduction and stabilization of AA-AuNPs. The average size of AuNPs was determined as 96.46 nm with Zetasizer. It was determined that AuNPs have a very strong inhibitory effect on pathogenic bacteria (Escherichia coli, Staphylococcus aureus, Bacillus subtillis and Pseudomonas aeruginosa) and Candida albicans by the minimum inhibitory concentration (MIC) method.
Relationship Between Lymph Node Metastasis and Lymph Node Density and Preoperative Neutrophil-Lymphocyte Ratio in Patients Undergoing Radical Cystectomy
(UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, 2021) Kölükçü, Engin; Atılgan, Doğan; Kuyucu, Yunus Emre; Unsal, Velid; Özbek, Latif Mustafa
Objective: This study aimed to evaluate the relationship between the preoperative neutrophil-lymphocyte ratio (NLR) and lymph node metastasis and lymph node density after radical cystectomy in patients with invasive urinary bladder cancer. Materials and Methods: Data of 89 patients who underwent radical cystectomy were examined. Our study included only cases with stage 2 urothelial bladder cancer. They were classified according to the lymph node status based on the surgical specimen. Patients with negative results were classified as group 1 and those with positive results as group 2. Patients in group 2 were further evaluated in two subgroups according to their lymph node density. Accordingly, group 2A consisted of patients with lymph node density of <20%, and group 2B involved those with lymph node density of ≥20%. Groups were compared statistically according to NLR. Results: Of the patients, 71 (79.8%) were male. The patients’ mean ages and neutrophil and lymphocyte counts were 67.36±8.64 years, 6.89±3.02 K/µL, and 3.08±2.18 K/µL, respectively. NLRs of groups 1 and 2 were 2.80±2.25 and 4.59±2.97, respectively. The relationship between group 1 and 2 tumors was significant (p=0.008). NLR values were 3.82±2.49 and 5.20±3.25 in groups 2A and 2B, respectively. However, no significant relationship was found between these values (p=0.235). Conclusion: Although no positive correlation was found between NLR and lymph node density, we think that this inflammation marker is an invaluable parameter to predict lymph node metastasis
Citation - WoS: 1
Renoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model
(Walter de Gruyter, 2024) Katar, Muzaffer; Gevrek, Fikret; Fırat, Fatih; Kölükçü, Engin; Unsal, Velıd
Objectives: We aimed to analyze the effects of diacerein in a rat model of partial unilateral ureteral obstruction (PUUO). Methods: We randomly divided 24 female rats into three groups. Control group, PUUO group and PUUO + diacerein group. The PUUO group was subjected to the PUUO model for seven days. The PUUO + diacerein group received oral diacerein (80 mg/kg) for seven days. Spectrophotometric methods were employed to measure oxidative stress parameters, including malondialdehyde (MDA), protein carbonyl (PC) and antioxidant enzyme levels, including glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), while indicators of renal function, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinous- associated lipocalin (NGAL), along with inflammatory parameters interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were assessed using the ELISA method. Inflammatory parameters were measured in blood samples, and other parameters were analyzed in kidney tissue. Hematoxylin-eosin method examinations were used for histological analyses. Results: IL-1beta, TNF-alpha, and IL-6 levels were found to be significantly decreased in the PUUO + diacerein group compared to the PUUO group (p=0.006, p=0.002 and p=0.001, respectively). In the PUUO + diacerein group, GSH-Px and SOD activities increased compared with the PUUO group (p=0.031 and p=0.037, respectively). We also observed a significant improvement in renal function parameters, such as KIM-1 and NGAL levels in the PUUO + diacerein group compared to PUUO (p=0.002 and p=0.012, respectively). The PC and MDA levels were highest in the PUUO group (p<0.001). Similarly, the histopathologic tissue damage was the most prominent PUUO group (p<0.001). Conclusions: Our study found that diacerein is a highly effective pharmacologic agent in alleviating oxidative dam- age in PUUO model rats.
Citation - WoS: 1
Citation - Scopus: 1
Seasonal effect on fatty acid composition in phospholipid classes and triacylglycerols of male Capoeta umbla
(CSIC Consejo Superior de Investigaciones Cientifica, 2023) Kaçar, Semra; Kayhan Kaya, Hacer; Başhan, Mehmet
The seasonal changes in muscle tissue, total lipids and fatty acid composition of phospholipids (PL), triacylglycerol (TAG), and phospholipid classes of male Capoeta umbla were investigated in this study. Phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), and phosphatidylserine (PS) were identified as the major phospholipids (PLs) in the muscle tissue (PS). Triacylglycerols showed high contents of MUFA, 14:0, 16:1n-7, 18:1n-9, 18:2n-6, and 18:3n-3; while phospholipids presented high contents of AA, DHA, and 18:0. Myristic acid, 16:1n-7, 18:1n-9, monounsaturated fatty acids (MUFA), linoleic acid (18:2n-6), and linolenic acid (18:3n-3) were shown to be present in larger concentrations in TAG than in PL classes. In PL classes, 16:0, 18:0, arachidonic acid (20:4n-6) (AA), eicosapentaenoic acid (EPA) (20:5n-3), docosahexaenoic acid (DHA) (22:6n-3) and polyunsaturated fatty acid (ΣPUFA) were higher than the TAG fraction. The fatty acid composition of total lipid and lipid classes (TAG and PL) were affected by the seasonal variations and lipid fraction.
Citation - WoS: 1
Citation - Scopus: 1
Seasonal effects of the fatty acid composition of phospholipid and triacylglycerol in the muscle and liver of male Salmo trutta macrostigma
(GRASAS Y ACEITES, 2021) Kaçar, Semra; Kaya, H.; Başhan, M.
The seasonal effects on the fatty acid composition of triacylglycerol (TAG) and phospholipid (PL) in the muscle and liver of male Salmo trutta macrostigma were determined using the gas chromatographic (GC) method. The fatty acid (FA) compositions of total lipid, PL and TAG fractions were determined in muscle and liver tissues of S. trutta macrostigma. The phospholipids contained a higher proportion of 16:0 compared to the TAG in the muscle tissue of S. trutta macrostigma. Docosahexaenoic acid (22:6 ω-3) and eicosapentaenoic acid (20:5 ω-3) contents were high in both muscle and liver tissues. The total lipid contents in the muscle and liver were 1.07-2.45 and 3.00-4.64%, respectively. S. trutta macrostigma is a rich source of ω-3 and ω-6, polyunsaturated fatty acids (PUFA) with numerous benefits to human health. © 2021 CSIC Consejo Superior de Investigaciones Cientificas. All rights reserved.
Citation - WoS: 1
Citation - Scopus: 1
Triacylglycerol and Phospholipid Classes of Capoettaumbla
(Taylor & Francis Online, 2023) Kaçar, Semra; Kayhan Kaya, Hacer; Başhan, Mehmet
In this study, seasonal changes in the muscle tissue, total lipid, and fatty acid composition of phospholipid (PL), triacylglycerol (TAG), and phospholipid classes of female Capoeta umbla were investigated. Fatty acid compositions of TAG and PL classes were found to be different in C. umbla muscle. Percentages of myristic acid, 16:1n-7, 18:1n-9, monounsaturated fatty acid (ΣMUFA), linoleic acid (18:2n6), and linolenic acid (18:3n-3) were found to be higher in TAG than the values determined in PL classes. In PL classes, 16:0, 18:0, arachidonic acid (20:4n-6, AA), EPA (20:5n-3), DHA (22:6n-3), and polyunsaturated fatty acid (ΣPUFA) were higher than TAG fraction.
Utilization of edible mushroom for nanomaterial-based bioactive material development
(Iranian Journal of Materials Science and Engineering, 2021) Acay, Hilal; Yıldırım, Ayfer; Baran, Ayşe
Gold nanoparticles (AuNP) were synthesized using edible mushroom Russula delica (RD) in this study. Possibilities to evaluate these synthesized nanoparticles (RD-AuNPs) as bioactive substances were investigated. Characterization of synthesized RD-AuNPs were characterized via UV-vis, XRD, FTIR, EDX. In a spherical view, RD-AuNPs with a crystal size of 34.76 nm were synthesized. As a result, fungal systems used for nanomaterial biosynthesis as an effective alternative to chemical synthesis can be used in different biotechnological and medical applications. RD-AuNPs produced by green synthesis can be evaluated in this context.

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