Evaluation of Cardiac Functions in Neonates With Hypoxic Ischemic Encephalopathy

Abstract

Introduction: The aim of our study was to evaluate the role of cardiac markers in determining prognosis in newborns with Perinatal Asphyxia (PA). Method: Patients with a pH <7–7.15 base deficit −12> mmol/L were defined as PA. NT-proBNP, cardiac Troponin I (cTnI), creatine kinase MB levels were analyzed. Patients with excitus during follow-up were compared with patients with pathological MRI findings and cardiac markers. Results: A total of 115 infants with perinatal asphyxia were included in the study.cTnI levels was median 0.63 (min 0.1-max 4.2) ng/ml significantly higher in patients who died (p =.006). The predictive power of cTnI was evaluated and the threshold value of cTnI for predicting mortality was determined as 0.428 ng/ml with 87.5% sensitivity and 87.2% specificity. Conclusion: We found that cTnI level analyzed in the first hours of life in newborn infants with PA has value in predicting both mortality and cranial affections. © 2025 Taylor & Francis Group, LLC.